ENSDARG00000098753


Danio rerio

Features
Gene ID: ENSDARG00000098753
  
Biological name :elmo1
  
Synonyms : elmo1 / engulfment and cell motility 1 (ced-12 homolog, C. elegans)
  
Possible biological names infered from orthology : engulfment and cell motility 1 / Engulfment and cell motility protein 1 / Q8BPU7 / Q92556
  
Species: Danio rerio
  
Chr. number: 19
Strand: -1
Band:
Gene start: 33887589
Gene end: 34063567
  
Corresponding Affymetrix probe sets: Dr.1691.5.A1_at (Zebrafish Array)   NM_213091_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000132947
Ensembl peptide - ENSDARP00000151585
Ensembl peptide - ENSDARP00000133736
Ensembl peptide - ENSDARP00000132398
NCBI entrez gene - 406364     See in Manteia.
RefSeq - NM_213091
RefSeq - XM_009294311
RefSeq Peptide - NP_998256
swissprot - A0A0R4IJC9
swissprot - Q6NV39
swissprot - A0A0R4IHP8
ZFIN ID - ZDB-GENE-040426-2069
Ensembl - ENSDARG00000098753
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ELMO1ENSGALG00000035492Gallus gallus
 ELMO1ENSG00000155849Homo sapiens
 Elmo1ENSMUSG00000041112Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
elmo2 / engulfment and cell motility 2 / Q8BHL5* / Q96JJ3* / Engulfment and cell motility protein 2 *ENSDARG0000006352763
elmo3 / engulfment and cell motility 3 / Q96BJ8*ENSDARG0000004212658
si:dkey-56f14.7 / ELMO1* / Q8BPU7* / Q92556* / engulfment and cell motility 1* / Engulfment and cell motility protein 1 *ENSDARG0000005540025


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR006816  ELMO domain
 IPR011989  Armadillo-like helical
 IPR011993  PH-like domain superfamily
 IPR016024  Armadillo-type fold
 IPR024574  Domain of unknown function DUF3361
 IPR030715  Engulfment and cell motility protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001946 lymphangiogenesis IMP
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0060271 cilium assembly IGI


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
VEGFA-VEGFR2 Pathway
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000084 yolk yolk accumulation blood , abnormal
Show

 ZFA:0000114 heart heart edematous , abnormal
Show

 ZFA:0000151 pronephros pronephros cystic , abnormal
pronephros cilium assembly decreased process quality , abnormal
pronephros apoptotic process occurrence , ameliorated
pronephros apoptotic process increased occurrence , abnormal
pronephros renal filtration occurrence , ameliorated
pronephros renal filtration decreased occurrence , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel malformed , abnormal
intersegmental vessel increased width , abnormal
Show

 ZFA:0001557 pronephric glomerulus pronephric glomerulus increased width , abnormal
pronephric glomerulus width , ameliorated
Show

 ZFA:0001558 pronephric tubule pronephric tubule ciliary basal body organization decreased process quality , abnormal
pronephric tubule ciliary basal body mislocalised , abnormal
pronephric tubule ciliary basal body separated from pronephric tubule apical plasma membrane, abnormal
pronephric tubule length , ameliorated
pronephric tubule decreased length , abnormal
Show

 ZFA:0001673 pronephric podocyte pronephric podocyte glomerular visceral epithelial cell development decreased process quality , abnormal
pronephric podocyte podocyte foot malformed , abnormal
pronephric podocyte podocyte foot immature , abnormal
Show

 ZFA:0005025 dorsal longitudinal anastomotic vessel dorsal longitudinal anastomotic vessel malformed , abnormal
Show

 ZFA:0005034 parachordal vessel parachordal vessel aplastic , abnormal
Show

 ZFA:0005110 thoracic duct thoracic duct aplastic , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr