ENSGALG00000008341


Gallus gallus

Features
Gene ID: ENSGALG00000008341
  
Biological name :FURIN
  
Synonyms : FURIN / furin, paired basic amino acid cleaving enzyme
  
Possible biological names infered from orthology : P09958 / P23188
  
Species: Gallus gallus
  
Chr. number: 10
Strand: -1
Band:
Gene start: 20127189
Gene end: 20157789
  
Corresponding Affymetrix probe sets: Gga.1751.1.S1_at (Chicken Array)   GgaAffx.7616.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000013566
Ensembl peptide - ENSGALP00000051587
NCBI entrez gene - 395457     See in Manteia.
RefSeq - NM_204715
RefSeq Peptide - NP_990046
swissprot - Q91000
Ensembl - ENSGALG00000008341
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 furinaENSDARG00000062909Danio rerio
 furinbENSDARG00000070971Danio rerio
 FURINENSG00000140564Homo sapiens
 FurinENSMUSG00000030530Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PCSK5* / Q04592* / Q92824* / proprotein convertase subtilisin/kexin type 5*ENSGALG0000003325647
PCSK6 / proprotein convertase subtilisin/kexin type 6 / P29122*ENSGALG0000003007644
PCSK4 / proprotein convertase subtilisin/kexin type 4 / P29121* / Q6UW60*ENSGALG0000002638443
PCSK1 / proprotein convertase subtilisin/kexin type 1 / P29120* / P63239* / Neuroendocrine convertase 1 *ENSGALG0000001468141
PCSK2 / proprotein convertase subtilisin/kexin type 2 / P16519* / P21661*ENSGALG0000000873437
PCSK7 / proprotein convertase subtilisin/kexin type 7 / Q16549* / Q61139*ENSGALG0000002922030
PCSK5* / Q04592* / Q92824* / proprotein convertase subtilisin/kexin type 5*ENSGALG000000151642


Protein motifs (from Interpro)
Interpro ID Name
 IPR000209  Peptidase S8/S53 domain
 IPR002884  P domain
 IPR006212  Furin-like repeat
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR015500  Peptidase S8, subtilisin-related
 IPR022398  Peptidase S8, subtilisin, His-active site
 IPR023827  Peptidase S8, subtilisin, Asp-active site
 IPR023828  Peptidase S8, subtilisin, Ser-active site
 IPR032815  Peptidase S8, pro-domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006465 signal peptide processing IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0016486 peptide hormone processing IEA
 biological_processGO:0019058 viral life cycle IEA
 biological_processGO:0031638 zymogen activation IEA
 biological_processGO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process IEA
 biological_processGO:0032902 nerve growth factor production IEA
 biological_processGO:0032911 negative regulation of transforming growth factor beta1 production IEA
 biological_processGO:0032940 secretion by cell IEA
 biological_processGO:0042176 regulation of protein catabolic process IEA
 biological_processGO:0043043 peptide biosynthetic process IEA
 biological_processGO:0045714 regulation of low-density lipoprotein particle receptor biosynthetic process IEA
 biological_processGO:0052548 regulation of endopeptidase activity IEA
 biological_processGO:0090472 dibasic protein processing IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030140 trans-Golgi network transport vesicle IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042277 peptide binding IEA
 molecular_functionGO:0048406 nerve growth factor binding IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Elastic fibre formation
Activation of Matrix Metalloproteinases
Removal of aminoterminal propeptides from gamma-carboxylated proteins
NGF processing
Signaling by PDGF
Pre-NOTCH Processing in Golgi
TGF-beta receptor signaling activates SMADs
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000016833 F7 / coagulation factor VII precursor / P08709* / P70375* / coagulation factor VII* / Coagulation factor VII Factor VII light chain Factor VII heavy chain*  / reaction
 ENSGALG00000003642 PDGFA / platelet derived growth factor subunit A / P04085*  / reaction
 ENSGALG00000012178 PDGFB / platelet derived growth factor subunit B / P01127* / platelet derived growth factor, B polypeptide*  / reaction
 ENSGALG00000002375 NOTCH1 / P46531* / Q01705* / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain*  / reaction
 ENSGALG00000015409 PROS1 / protein S / P07225* / Q08761* / protein S (alpha)*  / reaction
 ENSGALG00000026677 F10 / P25155 / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain / O88947* / P00742* / coagulation factor X*  / reaction
 ENSGALG00000008332 F2 / prothrombin precursor / P00734* / P19221* / coagulation factor II, thrombin* / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain*  / reaction
 ENSGALG00000001780 PROC / vitamin K-dependent protein C precursor / P33587* / P04070* / protein C, inactivator of coagulation factors Va and VIIIa* / Vitamin K-dependent protein C Vitamin K-dependent protein...  / reaction
 ENSGALG00000029494 BGLAP / bone gamma-carboxyglutamate protein / P86547* / Bglap2* / Bglap3* / P02818* / P54615* / P86546* / Osteocalcin * / Osteocalcin-2 * / Osteocalcin-related protein *  / reaction
 ENSGALG00000016832 PROZ / protein Z, vitamin K dependent plasma glycoprotein / P22891* / Q9CQW3*  / reaction
 ENSGALG00000032031 MMP16 / matrix metallopeptidase 16 / P51512* / Q9WTR0* / Matrix metalloproteinase-16 *  / reaction
 ENSGALG00000002556 NGF / nerve growth factor / P01138* / P01139* / Beta-nerve growth factor *  / reaction






 

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