ENSGALG00000030076


Gallus gallus

Features
Gene ID: ENSGALG00000030076
  
Biological name :PCSK6
  
Synonyms : PCSK6 / proprotein convertase subtilisin/kexin type 6
  
Possible biological names infered from orthology : P29122
  
Species: Gallus gallus
  
Chr. number: 10
Strand: -1
Band:
Gene start: 17654331
Gene end: 17675926
  
Corresponding Affymetrix probe sets: Gga.20041.1.S1_at (Chicken Array)   Gga.246.1.S1_at (Chicken Array)   GgaAffx.20832.1.S1_s_at (Chicken Array)   GgaAffx.4528.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000044947
NCBI entrez gene - 395454     See in Manteia.
RefSeq - XM_015292134
swissprot - A0A1D5NX54
Ensembl - ENSGALG00000030076
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pcsk6ENSDARG00000104574Danio rerio
 PCSK6ENSG00000140479Homo sapiens
 Pcsk6ENSMUSG00000030513Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PCSK5* / Q04592* / Q92824* / proprotein convertase subtilisin/kexin type 5*ENSGALG0000003325656
FURIN / furin, paired basic amino acid cleaving enzyme / P09958* / P23188*ENSGALG0000000834138
PCSK1 / proprotein convertase subtilisin/kexin type 1 / P29120* / P63239* / Neuroendocrine convertase 1 *ENSGALG0000001468133
PCSK4 / proprotein convertase subtilisin/kexin type 4 / P29121* / Q6UW60*ENSGALG0000002638431
PCSK2 / proprotein convertase subtilisin/kexin type 2 / P16519* / P21661*ENSGALG0000000873429
PCSK7 / proprotein convertase subtilisin/kexin type 7 / Q16549* / Q61139*ENSGALG0000002922027
PCSK5* / Q04592* / Q92824* / proprotein convertase subtilisin/kexin type 5*ENSGALG000000151641


Protein motifs (from Interpro)
Interpro ID Name
 IPR000209  Peptidase S8/S53 domain
 IPR000742  EGF-like domain
 IPR002884  P domain
 IPR006212  Furin-like repeat
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR010909  PLAC
 IPR015500  Peptidase S8, subtilisin-related
 IPR022398  Peptidase S8, subtilisin, His-active site
 IPR023827  Peptidase S8, subtilisin, Asp-active site
 IPR023828  Peptidase S8, subtilisin, Ser-active site
 IPR032778  Growth factor receptor domain 4
 IPR032815  Peptidase S8, pro-domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007354 zygotic determination of anterior/posterior axis, embryo IEA
 biological_processGO:0007368 determination of left/right symmetry IEA
 biological_processGO:0009100 glycoprotein metabolic process IEA
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0016486 peptide hormone processing IEA
 biological_processGO:0032902 nerve growth factor production IEA
 biological_processGO:0032940 secretion by cell IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0048406 nerve growth factor binding IEA


Pathways (from Reactome)
Pathway description
NGF processing
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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