ENSG00000140479


Homo sapiens

Features
Gene ID: ENSG00000140479
  
Biological name :PCSK6
  
Synonyms : P29122 / PCSK6 / proprotein convertase subtilisin/kexin type 6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q26.3
Gene start: 101297142
Gene end: 101525202
  
Corresponding Affymetrix probe sets: 1553531_at (Human Genome U133 Plus 2.0 Array)   207414_s_at (Human Genome U133 Plus 2.0 Array)   210553_x_at (Human Genome U133 Plus 2.0 Array)   211262_at (Human Genome U133 Plus 2.0 Array)   211263_s_at (Human Genome U133 Plus 2.0 Array)   242662_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000481556
Ensembl peptide - ENSP00000482831
Ensembl peptide - ENSP00000483048
Ensembl peptide - ENSP00000487813
Ensembl peptide - ENSP00000479496
Ensembl peptide - ENSP00000482760
Ensembl peptide - ENSP00000332052
Ensembl peptide - ENSP00000381246
Ensembl peptide - ENSP00000452839
Ensembl peptide - ENSP00000452997
Ensembl peptide - ENSP00000453155
Ensembl peptide - ENSP00000453771
Ensembl peptide - ENSP00000477768
Ensembl peptide - ENSP00000478081
NCBI entrez gene - 5046     See in Manteia.
OMIM - 167405
RefSeq - NM_002570
RefSeq - NM_138325
RefSeq - NM_138324
RefSeq - NM_138323
RefSeq - NM_138322
RefSeq - NM_138319
RefSeq - NM_001291309
RefSeq Peptide - NP_612192
RefSeq Peptide - NP_001278238
RefSeq Peptide - NP_002561
RefSeq Peptide - NP_612195
RefSeq Peptide - NP_612196
RefSeq Peptide - NP_612197
RefSeq Peptide - NP_612198
swissprot - A0A0J9YW51
swissprot - A0A087X025
swissprot - A0A087WZR0
swissprot - A0A087WY68
swissprot - P29122
swissprot - H0YMW5
swissprot - H7BXT3
swissprot - H0YLC8
swissprot - H0YKZ4
swissprot - H0YKK2
swissprot - H0Y3Q0
Ensembl - ENSG00000140479
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pcsk6ENSDARG00000104574Danio rerio
 PCSK6ENSGALG00000030076Gallus gallus
 Pcsk6ENSMUSG00000030513Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PCSK5 / Q92824 / proprotein convertase subtilisin/kexin type 5ENSG0000009913952
FURIN / P09958 / furin, paired basic amino acid cleaving enzymeENSG0000014056437
PCSK4 / Q6UW60 / proprotein convertase subtilisin/kexin type 4ENSG0000011525733
PCSK1 / P29120 / proprotein convertase subtilisin/kexin type 1ENSG0000017542632
PCSK7 / Q16549 / proprotein convertase subtilisin/kexin type 7ENSG0000016061328
PCSK2 / P16519 / proprotein convertase subtilisin/kexin type 2ENSG0000012585128


Protein motifs (from Interpro)
Interpro ID Name
 IPR000209  Peptidase S8/S53 domain
 IPR000742  EGF-like domain
 IPR002884  P domain
 IPR006212  Furin-like repeat
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR010909  PLAC
 IPR015500  Peptidase S8, subtilisin-related
 IPR022398  Peptidase S8, subtilisin, His-active site
 IPR023827  Peptidase S8, subtilisin, Asp-active site
 IPR023828  Peptidase S8, subtilisin, Ser-active site
 IPR032778  Growth factor receptor domain 4
 IPR032815  Peptidase S8, pro-domain
 IPR034182  Kexin/furin catalytic domain
 IPR036852  Peptidase S8/S53 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007354 zygotic determination of anterior/posterior axis, embryo IEA
 biological_processGO:0007368 determination of left/right symmetry IEA
 biological_processGO:0009100 glycoprotein metabolic process IDA
 biological_processGO:0016485 protein processing IDA
 biological_processGO:0016486 peptide hormone processing IDA
 biological_processGO:0030510 regulation of BMP signaling pathway TAS
 biological_processGO:0032455 nerve growth factor processing TAS
 biological_processGO:0032902 nerve growth factor production IDA
 biological_processGO:0032940 secretion by cell IDA
 biological_processGO:0051004 regulation of lipoprotein lipase activity TAS
 biological_processGO:0070268 cornification TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031012 extracellular matrix IDA
 molecular_functionGO:0004175 endopeptidase activity TAS
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008201 heparin binding IDA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0048406 nerve growth factor binding IDA


Pathways (from Reactome)
Pathway description
Signaling by NODAL
NGF processing
Formation of the cornified envelope
Assembly of active LPL and LIPC lipase complexes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000156574 NODAL / Q96S42 / nodal growth differentiation factor  / reaction
 ENSG00000134259 NGF / P01138 / nerve growth factor  / reaction
 ENSG00000175445 LPL / P06858 / lipoprotein lipase  / reaction
 ENSG00000277494 Q8IV16 / GPIHBP1 / glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1  / reaction
 ENSG00000143631 FLG / P20930 / filaggrin  / reaction






 

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