ENSG00000115257


Homo sapiens

Features
Gene ID: ENSG00000115257
  
Biological name :PCSK4
  
Synonyms : PCSK4 / proprotein convertase subtilisin/kexin type 4 / Q6UW60
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.3
Gene start: 1481428
Gene end: 1490752
  
Corresponding Affymetrix probe sets: 230901_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000466742
Ensembl peptide - ENSP00000300954
Ensembl peptide - ENSP00000465102
NCBI entrez gene - 54760     See in Manteia.
OMIM - 600487
RefSeq - XM_017026897
RefSeq - XM_011528092
RefSeq - XM_011528093
RefSeq - XM_011528094
RefSeq - XM_011528095
RefSeq - XM_011528096
RefSeq - NM_017573
RefSeq - XM_005259586
RefSeq - XM_011528085
RefSeq - XM_011528086
RefSeq - XM_011528087
RefSeq - XM_011528088
RefSeq - XM_011528089
RefSeq - XM_011528090
RefSeq - XM_011528091
RefSeq Peptide - NP_060043
swissprot - K7EJB6
swissprot - K7EN14
swissprot - A0A140VJQ9
swissprot - Q6UW60
Ensembl - ENSG00000115257
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PCSK4ENSGALG00000026384Gallus gallus
 Pcsk4ENSMUSG00000020131Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FURIN / P09958 / furin, paired basic amino acid cleaving enzymeENSG0000014056453
PCSK5 / Q92824 / proprotein convertase subtilisin/kexin type 5ENSG0000009913944
PCSK6 / P29122 / proprotein convertase subtilisin/kexin type 6ENSG0000014047943
PCSK1 / P29120 / proprotein convertase subtilisin/kexin type 1ENSG0000017542638
PCSK2 / P16519 / proprotein convertase subtilisin/kexin type 2ENSG0000012585135
PCSK7 / Q16549 / proprotein convertase subtilisin/kexin type 7ENSG0000016061334


Protein motifs (from Interpro)
Interpro ID Name
 IPR000209  Peptidase S8/S53 domain
 IPR002884  P domain
 IPR006212  Furin-like repeat
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR015500  Peptidase S8, subtilisin-related
 IPR022398  Peptidase S8, subtilisin, His-active site
 IPR023827  Peptidase S8, subtilisin, Asp-active site
 IPR023828  Peptidase S8, subtilisin, Ser-active site
 IPR032815  Peptidase S8, pro-domain
 IPR034182  Kexin/furin catalytic domain
 IPR036852  Peptidase S8/S53 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007339 binding of sperm to zona pellucida ISS
 biological_processGO:0007340 acrosome reaction ISS
 biological_processGO:0009566 fertilization ISS
 biological_processGO:0016485 protein processing IDA
 biological_processGO:0022414 reproductive process ISS
 biological_processGO:0048240 sperm capacitation ISS
 cellular_componentGO:0001669 acrosomal vesicle ISS
 cellular_componentGO:0002080 acrosomal membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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