ENSMUSG00000020131


Mus musculus

Features
Gene ID: ENSMUSG00000020131
  
Biological name :Pcsk4
  
Synonyms : P29121 / Pcsk4 / Proprotein convertase subtilisin/kexin type 4
  
Possible biological names infered from orthology : Q6UW60
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 80321283
Gene end: 80329498
  
Corresponding Affymetrix probe sets: 10370780 (MoGene1.0st)   1425824_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020340
Ensembl peptide - ENSMUSP00000137719
Ensembl peptide - ENSMUSP00000137809
NCBI entrez gene - 18551     See in Manteia.
MGI - MGI:97514
RefSeq - XM_006513369
RefSeq - XM_006513364
RefSeq - XM_006513365
RefSeq - XM_006513366
RefSeq - XM_006513368
RefSeq - NM_008793
RefSeq - XM_006513358
RefSeq - XM_006513359
RefSeq - XM_006513360
RefSeq - XM_006513361
RefSeq - XM_006513362
RefSeq - XM_006513363
RefSeq Peptide - NP_032819
swissprot - M0QWG0
swissprot - M0QW95
swissprot - P29121
Ensembl - ENSMUSG00000020131
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PCSK4ENSGALG00000026384Gallus gallus
 PCSK4ENSG00000115257Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Furin / P23188 / P09958* / furin, paired basic amino acid cleaving enzyme*ENSMUSG0000003053054
Pcsk6 / proprotein convertase subtilisin/kexin type 6 / P29122*ENSMUSG0000003051347
Pcsk5 / Q04592 / Proprotein convertase subtilisin/kexin type 5 / Q92824*ENSMUSG0000002471345
Pcsk1 / P63239 / Neuroendocrine convertase 1 / P29120* / proprotein convertase subtilisin/kexin type 1*ENSMUSG0000002158743
Pcsk2 / P21661 / proprotein convertase subtilisin/kexin type 2 / P16519*ENSMUSG0000002741940
Pcsk7 / Q61139 / Proprotein convertase subtilisin/kexin type 7 / Q16549*ENSMUSG0000003538236


Protein motifs (from Interpro)
Interpro ID Name
 IPR000209  Peptidase S8/S53 domain
 IPR002884  P domain
 IPR008979  Galactose-binding-like domain superfamily
 IPR015500  Peptidase S8, subtilisin-related
 IPR022398  Peptidase S8, subtilisin, His-active site
 IPR023827  Peptidase S8, subtilisin, Asp-active site
 IPR023828  Peptidase S8, subtilisin, Ser-active site
 IPR032815  Peptidase S8, pro-domain
 IPR034182  Kexin/furin catalytic domain
 IPR036852  Peptidase S8/S53 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007339 binding of sperm to zona pellucida IMP
 biological_processGO:0007340 acrosome reaction IMP
 biological_processGO:0009566 fertilization IDA
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0022414 reproductive process IMP
 biological_processGO:0048240 sperm capacitation IDA
 cellular_componentGO:0001669 acrosomal vesicle IDA
 cellular_componentGO:0002080 acrosomal membrane IDA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Runx1tm1Dow/Runx1tm1Dow
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pcsk4tm1Mbi/Pcsk4tm1Mbi
Genetic Background: B6.129P2-Pcsk4tm1Mbi

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Runx1tm1Dow/Runx1tm1Dow
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pcsk4tm1Mbi/Pcsk4tm1Mbi
Genetic Background: B6.129P2-Pcsk4tm1Mbi

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Runx1tm1Dow/Runx1tm1Dow
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm1Dow/Runx1tm1Dow
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004179 transmission ratio distortion "the occurence of an allele or haplotype in the offspring of an organism at skewed Mendelian ratios" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm1Dow/Runx1tm1Dow
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pcsk4tm1Mbi/Pcsk4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pcsk4tm1Mbi/Pcsk4tm1Mbi
Genetic Background: B6.129P2-Pcsk4tm1Mbi

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Pcsk1tm1b(EUCOMM)Wtsi/Pcsk1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pcsk1tm1b(EUCOMM)Wtsi/Ics

 MP:0009282 reduced hyperactivated sperm motility "loss or reduction of the hyperactivated type of sperm mobility, impairing the ability of sperm to reach the site of fertilization and to penetrate the oocyte vestments; a block in hyperactivated motility may also impair the ability of a sperm to fertilize an oocyte in vitro" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx1tm1Dow/Runx1tm1Dow
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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