ENSMUSG00000027419


Mus musculus

Features
Gene ID: ENSMUSG00000027419
  
Biological name :Pcsk2
  
Synonyms : P21661 / Pcsk2 / proprotein convertase subtilisin/kexin type 2
  
Possible biological names infered from orthology : P16519
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: G1
Gene start: 143546156
Gene end: 143816285
  
Corresponding Affymetrix probe sets: 10476633 (MoGene1.0st)   1428305_at (Mouse Genome 430 2.0 Array)   1444147_at (Mouse Genome 430 2.0 Array)   1447991_at (Mouse Genome 430 2.0 Array)   1447992_s_at (Mouse Genome 430 2.0 Array)   1448312_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028905
NCBI entrez gene - 18549     See in Manteia.
MGI - MGI:97512
RefSeq - NM_008792
RefSeq Peptide - NP_032818
swissprot - P21661
swissprot - Q547J8
Ensembl - ENSMUSG00000027419
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pcsk2ENSDARG00000019451Danio rerio
 PCSK2ENSGALG00000008734Gallus gallus
 PCSK2ENSG00000125851Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pcsk1 / P63239 / Neuroendocrine convertase 1 / P29120* / proprotein convertase subtilisin/kexin type 1*ENSMUSG0000002158744
Furin / P23188 / P09958* / furin, paired basic amino acid cleaving enzyme*ENSMUSG0000003053044
Pcsk6 / proprotein convertase subtilisin/kexin type 6 / P29122*ENSMUSG0000003051343
Pcsk5 / Q04592 / Proprotein convertase subtilisin/kexin type 5 / Q92824*ENSMUSG0000002471342
Pcsk4 / P29121 / Proprotein convertase subtilisin/kexin type 4 / Q6UW60*ENSMUSG0000002013141
Pcsk7 / Q61139 / Proprotein convertase subtilisin/kexin type 7 / Q16549*ENSMUSG0000003538234


Protein motifs (from Interpro)
Interpro ID Name
 IPR000209  Peptidase S8/S53 domain
 IPR002884  P domain
 IPR008979  Galactose-binding-like domain superfamily
 IPR015500  Peptidase S8, subtilisin-related
 IPR022398  Peptidase S8, subtilisin, His-active site
 IPR023827  Peptidase S8, subtilisin, Asp-active site
 IPR023828  Peptidase S8, subtilisin, Ser-active site
 IPR032815  Peptidase S8, pro-domain
 IPR034182  Kexin/furin catalytic domain
 IPR036852  Peptidase S8/S53 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis ISO
 biological_processGO:0007399 nervous system development IEP
 biological_processGO:0016485 protein processing IDA
 biological_processGO:0016486 peptide hormone processing IDA
 biological_processGO:0016540 protein autoprocessing IDA
 biological_processGO:0030070 insulin processing IEA
 biological_processGO:0034230 enkephalin processing IDA
 biological_processGO:0034231 islet amyloid polypeptide processing IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030133 transport vesicle IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004175 endopeptidase activity IDA
 molecular_functionGO:0004252 serine-type endopeptidase activity IDA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: AtrnGt(PST112)Byg/AtrnGt(PST112)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Irf7tm1Ttg/Irf7tm1Ttg
Genetic Background: B6.129P2-Irf7tm1Ttg

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Irf7tm1Ttg/Irf7tm1Ttg
Genetic Background: B6.129P2-Irf7tm1Ttg

 MP:0002164 abnormal gland physiology "altered glandular secretion not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0002696 decreased circulating glucagon level "lower than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Irf7tm1Ttg/Irf7tm1Ttg
Genetic Background: B6.129P2-Irf7tm1Ttg

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pcsk2tm1Dfs/Pcsk2tm1Dfs
Genetic Background: B6;129-Pcsk2tm1Dfs/J

 MP:0002711 decreased glucagon secretion "less than normal release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Pcsk2tm1Dfs/Pcsk2tm1Dfs
Genetic Background: B6;129-Pcsk2tm1Dfs/J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0003365 glucagonoma "a pancreatic islet alpha cell adenoma that secretes excess glucagon" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Pcsk2tm1Dfs/Pcsk2tm1Dfs
Genetic Background: B6;129-Pcsk2tm1Dfs/J

 MP:0003430 islet cell adenoma "a benign epithelial neoplasm with a glandular organization present in islet cells of the pancreas" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Pcsk2tm1Dfs/Pcsk2tm1Dfs
Genetic Background: B6;129-Pcsk2tm1Dfs/J

 MP:0003972 decreased pituitary hormone level "less than the expected amount of any of the pituitary hormones in the blood or tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0004270 analgesia "inability to sense pain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: AtrnGt(PST112)Byg/AtrnGt(PST112)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0005216 abnormal pancreatic alpha cell morphology "malformation of the cells of the pancreas that secrete glucagon" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pcsk2tm1Dfs/Pcsk2tm1Dfs
Genetic Background: B6;129-Pcsk2tm1Dfs/J

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pcsk2tm1Dfs/Pcsk2tm1Dfs
Genetic Background: B6;129-Pcsk2tm1Dfs/J

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pcsk2tm1Dfs/Pcsk2tm1Dfs
Genetic Background: B6;129-Pcsk2tm1Dfs/J

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: AtrnGt(PST112)Byg/AtrnGt(PST112)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0008953 abnormal pancreatic somatostatin secretion "anomaly in the production or release from pancreatic delta cells of a 14 amino acid peptide that inhibits growth hormone release and is found in the central and peripheral nervous systems, the gut, and other organs" [MESH:D06.472.699.327.700.875]
Show

Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0009151 pancreatic ductal adenocarcinoma "adenocarcinoma that arises from the pancraetic ducts" [MESH:C04.557.470.200.025.232.750]
Show

Allelic Composition: Pcsk2tm1Dfs/Pcsk2tm1Dfs
Genetic Background: B6;129-Pcsk2tm1Dfs/J

 MP:0009153 pancreas tumor "tumors or cancer of the pancreas" [MESH:C04.588.274.761]
Show

Allelic Composition: Pcsk2tm1Dfs/Pcsk2tm1Dfs
Genetic Background: B6;129-Pcsk2tm1Dfs/J

 MP:0009171 enlarged pancreatic islets "increase in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Pcsk2tm1Dfs/Pcsk2tm1Dfs
Genetic Background: B6;129-Pcsk2tm1Dfs/J

 MP:0009175 abnormal pancreatic beta cell differentiation "atypical production of or inability to produce the cells of the pancreas that secrete insulin, and/or accumulation of pancreatic beta cell precursors" [MESH:A03.734.414.131]
Show

Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0009176 increased pancreatic alpha cell number "increase in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
Show

Allelic Composition: Pcsk2tm1Dfs/Pcsk2tm1Dfs
Genetic Background: B6;129-Pcsk2tm1Dfs/J

 MP:0009179 abnormal pancreatic alpha cell differentiation "atypical production of or inability to produce the cells of the pancreas that secrete glucagon, and/or accumulation of pancreatic alpha cell precursors" [MESH:A03.734.414.065]
Show

Allelic Composition: Pcsk2tm1Dfs/Pcsk2tm1Dfs
Genetic Background: B6;129-Pcsk2tm1Dfs/J

 MP:0009180 increased pancreatic delta cell number "increased number of the cells found in the pancreas that secrete somatostatin" [MESH:A03.556.875.875.440.854]
Show

Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0014109 increased pancreatic alpha cell proliferation "increase in the ability of the glucagon-producing cells of the islets of Langerhans in the endocrine pancreas to undergo expansion by cell division" [MGI:Anna]
Show

Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0030589 increased pancreatic alpha cell mass "greater total physical bulk or volume of a pancreatic alpha cell compared to the normal state" [MGI:anna]
Show

Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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