ENSDARG00000070971


Danio rerio

Features
Gene ID: ENSDARG00000070971
  
Biological name :furinb
  
Synonyms : furinb / furin (paired basic amino acid cleaving enzyme) b
  
Possible biological names infered from orthology : FURIN / furin, paired basic amino acid cleaving enzyme / P09958 / P23188
  
Species: Danio rerio
  
Chr. number: 25
Strand: -1
Band:
Gene start: 8755990
Gene end: 8916917
  
Corresponding Affymetrix probe sets: Dr.13866.1.A1_at (Zebrafish Array)   NM_001045109_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000115357
Ensembl peptide - ENSDARP00000095400
NCBI entrez gene - 566591     See in Manteia.
RefSeq - NM_001045109
RefSeq Peptide - NP_001038574
swissprot - F1QKU2
swissprot - F1Q7B1
ZFIN ID - ZDB-GENE-040901-2
Ensembl - ENSDARG00000070971
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FURINENSGALG00000008341Gallus gallus
 FURINENSG00000140564Homo sapiens
 FurinENSMUSG00000030530Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
furina / furin (paired basic amino acid cleaving enzyme) a / FURIN* / P09958* / furin, paired basic amino acid cleaving enzyme*ENSDARG0000006290970
pcsk5a / proprotein convertase subtilisin/kexin type 5a / PCSK5* / Q92824* / Q04592* / proprotein convertase subtilisin/kexin type 5*ENSDARG0000006753742
pcsk1 / proprotein convertase subtilisin/kexin type 1 / P29120* / P63239* / Neuroendocrine convertase 1 *ENSDARG0000000260038
pcsk2 / proprotein convertase subtilisin/kexin type 2 / P16519*ENSDARG0000001945133
pcsk5b / proprotein convertase subtilisin/kexin type 5b / PCSK5* / Q92824* / proprotein convertase subtilisin/kexin type 5*ENSDARG0000006051832
pcsk7 / proprotein convertase subtilisin/kexin type 7 / Q16549*ENSDARG0000006996829
pcsk6 / proprotein convertase subtilisin/kexin type 6 / P29122*ENSDARG0000010457415


Protein motifs (from Interpro)
Interpro ID Name
 IPR000209  Peptidase S8/S53 domain
 IPR002884  P domain
 IPR006212  Furin-like repeat
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR015500  Peptidase S8, subtilisin-related
 IPR022398  Peptidase S8, subtilisin, His-active site
 IPR023827  Peptidase S8, subtilisin, Asp-active site
 IPR023828  Peptidase S8, subtilisin, Ser-active site
 IPR032815  Peptidase S8, pro-domain
 IPR034182  Kexin/furin catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0051216 cartilage development IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Elastic fibre formation
Activation of Matrix Metalloproteinases
Removal of aminoterminal propeptides from gamma-carboxylated proteins
NGF processing
Signaling by PDGF
Pre-NOTCH Processing in Golgi
TGF-beta receptor signaling activates SMADs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000547 mouth mouth open , abnormal
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 ZFA:0001058 caudal fin caudal fin morphology , abnormal
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 ZFA:0001094 whole organism whole organism dead , abnormal
whole organism decreased life span , abnormal
whole organism decreased length , abnormal
whole organism edematous , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton morphology , abnormal
mandibular arch skeleton joint absent , abnormal
Show

 ZFA:0001228 pharyngeal arch 3 skeleton pharyngeal arch 3 skeleton decreased size , abnormal
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 ZFA:0001231 pharyngeal arch 4 skeleton pharyngeal arch 4 skeleton decreased size , abnormal
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 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage decreased size , abnormal
pharyngeal arch cartilage morphology , abnormal
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 ZFA:0005473 interhyal-epihyal joint interhyal-epihyal joint absent , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000037783 proza / protein Z, vitamin K-dependent plasma glycoprotein a / PROZ* / P22891* / protein Z, vitamin K dependent plasma glycoprotein*  / reaction
 ENSDARG00000008388 mmp14b / matrix metallopeptidase 14b (membrane-inserted) / MMP14* / P50281* / P53690* / matrix metallopeptidase 14* / Matrix metalloproteinase-14 *  / reaction
 ENSDARG00000029493 f9b / coagulation factor IXb / F9* / P16294* / P00740* / coagulation factor IX* / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain*  / reaction
 ENSDARG00000100782 zgc:163025 / F7 (1 of many) / F7* / P08709* / P70375* / coagulation factor VII* / Coagulation factor VII Factor VII light chain Factor VII heavy chain*  / reaction
 ENSDARG00000038139 pdgfbb / platelet-derived growth factor beta polypeptide b / PDGFB* / P01127* / platelet derived growth factor subunit B* / platelet derived growth factor, B polypeptide*  / reaction
 ENSDARG00000014050 ngfb / Q6YBR5 / nerve growth factor b (beta polypeptide) / NGF* / P01138* / P01139* / nerve growth factor* / Beta-nerve growth factor *  / reaction
 ENSDARG00000058961 ngfa / O73797 / nerve growth factor a (beta polypeptide) / NGF* / P01139* / P01138* / nerve growth factor* / Beta-nerve growth factor *  / reaction
 ENSDARG00000058876 mmp16b / matrix metallopeptidase 16b (membrane-inserted) / MMP16* / P51512* / Q9WTR0* / matrix metallopeptidase 16* / Matrix metalloproteinase-16 *  / reaction
 ENSDARG00000010097 f9a / coagulation factor IXa / F9* / P16294* / P00740* / coagulation factor IX* / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain*  / reaction
 ENSDARG00000036041 f2 / coagulation factor II (thrombin) / P00734* / P19221* / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain*  / reaction
 ENSDARG00000026325 mmp11a / matrix metallopeptidase 11a / MMP11* / P24347* / Q02853* / Stromelysin-3 * / matrix metallopeptidase 11*  / reaction
 ENSDARG00000110069 pdgfaa / platelet-derived growth factor alpha polypeptide a / PDGFA* / P04085* / platelet derived growth factor subunit A*  / reaction
 ENSDARG00000076900 prozb / protein Z, vitamin K-dependent plasma glycoprotein b / PROZ* / P22891* / Q9CQW3* / protein Z, vitamin K dependent plasma glycoprotein*  / reaction
 ENSDARG00000088581 f10 / coagulation factor X / O88947* / P00742* / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain*  / reaction
 ENSDARG00000086778 pdgfba / platelet-derived growth factor beta polypeptide a / PDGFB* / P01127* / platelet derived growth factor subunit B* / platelet derived growth factor, B polypeptide*  / reaction
 ENSDARG00000034895 tgfb1b / transforming growth factor, beta 1b / TGFB1* / P04202* / P01137* / transforming growth factor beta 1*  / reaction






 

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