ENSDARG00000037783


Danio rerio

Features
Gene ID: ENSDARG00000037783
  
Biological name :proza
  
Synonyms : protein Z, vitamin K-dependent plasma glycoprotein a / proza
  
Possible biological names infered from orthology : P22891 / protein Z, vitamin K dependent plasma glycoprotein / PROZ / Q9CQW3
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 62382661
Gene end: 62393457
  
Corresponding Affymetrix probe sets: Dr.14091.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000115343
Ensembl peptide - ENSDARP00000156930
Ensembl peptide - ENSDARP00000092645
NCBI entrez gene - 768176     See in Manteia.
RefSeq - NM_001327792
RefSeq Peptide - NP_001314721
swissprot - F1Q5S2
swissprot - F1Q6I8
ZFIN ID - ZDB-GENE-061013-403
Ensembl - ENSDARG00000037783
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PROZENSGALG00000016832Gallus gallus
 PROZENSG00000126231Homo sapiens
 ProzENSMUSG00000031445Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
f10 / coagulation factor X / O88947* / P00742* / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain*ENSDARG0000008858133
f7 / coagulation factor VII / P08709* / P70375* / Coagulation factor VII Factor VII light chain Factor VII heavy chain*ENSDARG0000003486232
f9b / coagulation factor IXb / F9* / P16294* / P00740* / coagulation factor IX* / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain*ENSDARG0000002949331
proca / protein C (inactivator of coagulation factors Va and VIIIa), a / PROC* / P33587* / P04070* / protein C, inactivator of coagulation factors Va and VIIIa* / Vitamin K-dependent protei...ENSDARG0000003825831
proca / protein C (inactivator of coagulation factors Va and VIIIa), a / PROC* / P33587* / P04070* / protein C, inactivator of coagulation factors Va and VIIIa* / Vitamin K-dependent protei...ENSDARG0000009307931
f9a / coagulation factor IXa / F9* / P16294* / P00740* / coagulation factor IX* / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain*ENSDARG0000001009730
zgc:163025 / F7 (1 of many) / F7* / P08709* / P70375* / coagulation factor VII* / Coagulation factor VII Factor VII light chain Factor VII heavy chain*ENSDARG0000010078229
f7i / coagulation factor VIIi / F7* / P70375* / P08709* / coagulation factor VII* / Coagulation factor VII Factor VII light chain Factor VII heavy chain*ENSDARG0000007582729
CABZ01044048.1ENSDARG0000001146328
prozb / protein Z, vitamin K-dependent plasma glycoprotein b / PROZ* / P22891* / Q9CQW3* / protein Z, vitamin K dependent plasma glycoprotein*ENSDARG0000007690028
masp1 / mannan-binding lectin serine peptidase 1 / P48740* / P98064* / Mus musculus mannan-binding lectin serine peptidase 1 (Masp1), transcript variant 1, mRNA.*ENSDARG0000006872622
masp2 / mannan-binding lectin serine peptidase 2 / O00187* / Q91WP0* / Mannan-binding lectin serine protease 2 Mannan-binding lectin serine protease 2 A chain Mannan-binding lectin serine p...ENSDARG0000000798822
pamr1 / peptidase domain containing associated with muscle regeneration 1 / Q6UXH9* / Q8BU25* / Inactive serine protease PAMR1 *ENSDARG0000009348019
c1r / complement component 1, r subcomponent / C1S* / P09871* / complement C1s*ENSDARG0000010024818
si:ch211-102l7.3 / PAMR1 (1 of many) / PAMR1* / Q6UXH9* / Q8BU25* / Inactive serine protease PAMR1 * / peptidase domain containing associated with muscle regeneration 1*ENSDARG0000010318416
wu:fd46c06 / C1S* / P09871* / complement C1s*ENSDARG0000010209414
hp / haptoglobin / HPR* / P00738* / P00739* / Q61646* / haptoglobin-related protein* / Haptoglobin Haptoglobin alpha chain Haptoglobin beta chain*ENSDARG0000005189013
c1s / complement component 1, s subcomponentENSDARG000001005998


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000294  Gamma-carboxyglutamic acid-rich (GLA) domain
 IPR000742  EGF-like domain
 IPR001254  Serine proteases, trypsin domain
 IPR001881  EGF-like calcium-binding domain
 IPR009003  Peptidase S1, PA clan
 IPR013032  EGF-like, conserved site
 IPR017857  Coagulation factor-like, Gla domain superfamily
 IPR018097  EGF-like calcium-binding, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0030195 negative regulation of blood coagulation IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0004252 serine-type endopeptidase activity IBA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000017 endoderm endoderm hypoplastic , abnormal
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 ZFA:0000024 retinal ganglion cell layer retinal ganglion cell layer hypoplastic , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000076 swim bladder swim bladder hypoplastic , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
eye anterior-posterior axis decreased size , abnormal
eye dorsal-ventral axis decreased size , abnormal
eye medial-lateral axis decreased size , abnormal
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 ZFA:0000119 retinal inner nuclear layer retinal inner nuclear layer hypoplastic , abnormal
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 ZFA:0000143 retinal photoreceptor layer retinal photoreceptor layer hypoplastic , abnormal
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 ZFA:0001078 thymus thymus epithelial cell decreased thickness , abnormal
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 ZFA:0001094 whole organism whole organism edematous , abnormal
whole organism dead , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton deformed , abnormal
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 ZFA:0001249 exocrine pancreas exocrine pancreas decreased size , abnormal
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 ZFA:0001306 pharyngeal arch pharyngeal arch hypoplastic , abnormal
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 ZFA:0001338 intestine intestine decreased size , abnormal
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 ZFA:0001464 retinal outer nuclear layer retinal outer nuclear layer hypoplastic , abnormal
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 ZFA:0001611 pharyngeal arch 2 pharyngeal arch 2 decreased size , abnormal
pharyngeal arch 2 malformed , abnormal
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 ZFA:0001612 pharyngeal arch 1 pharyngeal arch 1 decreased size , abnormal
pharyngeal arch 1 malformed , abnormal
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 ZFA:0009014 hematopoietic stem cell hematopoietic stem cell decreased amount , abnormal
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 ZFA:0009046 T cell T cell absent , abnormal
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000062909 furina / furin (paired basic amino acid cleaving enzyme) a / FURIN* / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction
 ENSDARG00000070971 furinb / furin (paired basic amino acid cleaving enzyme) b / FURIN* / P23188* / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction






 

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