ENSDARG00000100248


Danio rerio

Features
Gene ID: ENSDARG00000100248
  
Biological name :c1r
  
Synonyms : c1r / complement component 1, r subcomponent
  
Possible biological names infered from orthology : C1S / C1s1 / C1s2 / complement C1s / complement component 1, s subcomponent 1 / complement component 1, s subcomponent 2 / P09871 / Q8CFG8
  
Species: Danio rerio
  
Chr. number: 16
Strand: -1
Band:
Gene start: 31662256
Gene end: 31675736
  
Corresponding Affymetrix probe sets: Dr.4216.1.A1_at (Zebrafish Array)   NM_001030150_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000130180
Ensembl peptide - ENSDARP00000134844
NCBI entrez gene - 560927     See in Manteia.
RefSeq - NM_001030150
RefSeq Peptide - NP_001025321
swissprot - A0A0R4IL35
swissprot - A0A0R4IAG3
swissprot - Q4V9I1
ZFIN ID - ZDB-GENE-050913-24
Ensembl - ENSDARG00000100248
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 C1SENSGALG00000014603Gallus gallus
 C1SENSG00000182326Homo sapiens
 C1s1ENSMUSG00000038521Mus musculus
 C1s2ENSMUSG00000079343Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
wu:fd46c06 / C1S* / P09871* / complement C1s*ENSDARG0000010209448
masp2 / mannan-binding lectin serine peptidase 2 / O00187* / Q91WP0* / Mannan-binding lectin serine protease 2 Mannan-binding lectin serine protease 2 A chain Mannan-binding lectin serine p...ENSDARG0000000798836
masp1 / mannan-binding lectin serine peptidase 1 / P48740* / P98064* / Mus musculus mannan-binding lectin serine peptidase 1 (Masp1), transcript variant 1, mRNA.*ENSDARG0000006872634
pamr1 / peptidase domain containing associated with muscle regeneration 1 / Q6UXH9* / Q8BU25* / Inactive serine protease PAMR1 *ENSDARG0000009348020
si:ch211-102l7.3 / PAMR1 (1 of many) / PAMR1* / Q6UXH9* / Q8BU25* / Inactive serine protease PAMR1 * / peptidase domain containing associated with muscle regeneration 1*ENSDARG0000010318419
CABZ01044048.1ENSDARG0000001146318
f7 / coagulation factor VII / P08709* / P70375* / Coagulation factor VII Factor VII light chain Factor VII heavy chain*ENSDARG0000003486217
f9a / coagulation factor IXa / F9* / P16294* / P00740* / coagulation factor IX* / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain*ENSDARG0000001009717
f10 / coagulation factor X / O88947* / P00742* / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain*ENSDARG0000008858117
zgc:163025 / F7 (1 of many) / F7* / P08709* / P70375* / coagulation factor VII* / Coagulation factor VII Factor VII light chain Factor VII heavy chain*ENSDARG0000010078216
f9b / coagulation factor IXb / F9* / P16294* / P00740* / coagulation factor IX* / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain*ENSDARG0000002949316
proca / protein C (inactivator of coagulation factors Va and VIIIa), a / PROC* / P33587* / P04070* / protein C, inactivator of coagulation factors Va and VIIIa* / Vitamin K-dependent protei...ENSDARG0000003825816
proca / protein C (inactivator of coagulation factors Va and VIIIa), a / PROC* / P33587* / P04070* / protein C, inactivator of coagulation factors Va and VIIIa* / Vitamin K-dependent protei...ENSDARG0000009307916
c1s / complement component 1, s subcomponentENSDARG0000010059916
f7i / coagulation factor VIIi / F7* / P70375* / P08709* / coagulation factor VII* / Coagulation factor VII Factor VII light chain Factor VII heavy chain*ENSDARG0000007582715
prozb / protein Z, vitamin K-dependent plasma glycoprotein b / PROZ* / P22891* / Q9CQW3* / protein Z, vitamin K dependent plasma glycoprotein*ENSDARG0000007690011
proza / protein Z, vitamin K-dependent plasma glycoprotein a / PROZ* / P22891* / protein Z, vitamin K dependent plasma glycoprotein*ENSDARG0000003778311
hp / haptoglobin / HPR* / P00738* / P00739* / Q61646* / haptoglobin-related protein* / Haptoglobin Haptoglobin alpha chain Haptoglobin beta chain*ENSDARG0000005189010


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000436  Sushi/SCR/CCP domain
 IPR000742  EGF-like domain
 IPR000859  CUB domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR001881  EGF-like calcium-binding domain
 IPR009003  Peptidase S1, PA clan
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008150 biological_process ND
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
Initial triggering of complement
Classical antibody-mediated complement activation
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000044613 c1qa / complement component 1, q subcomponent, A chain / P02745* / P98086* / complement C1q A chain* / Complement C1q subcomponent subunit A *  / complex
 ENSDARG00000058053 serping1 / serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 / P05155* / P97290* / serpin family G member 1* / serine (or cysteine) peptidase inhibitor, clade G, member 1*  / reaction / complex
 ENSDARG00000100248 c1r / complement component 1, r subcomponent / C1S* / P09871* / complement C1s*  / complex
 ENSDARG00000015065 c4 / complement component 4 / C4A* / C4B* / P0C0L5* / P01029* / P0C0L4* / complement C4B (Chido blood group)* / complement C4A (Rodgers blood group)* / Complement C4-B Complement C4 beta ch...  / reaction






 

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