ENSDARG00000058961


Danio rerio

Features
Gene ID: ENSDARG00000058961
  
Biological name :ngfa
  
Synonyms : nerve growth factor a (beta polypeptide) / ngfa / O73797
  
Possible biological names infered from orthology : Beta-nerve growth factor / nerve growth factor / NGF / P01138 / P01139
  
Species: Danio rerio
  
Chr. number: 23
Strand: -1
Band:
Gene start: 4929442
Gene end: 4975517
  
Corresponding Affymetrix probe sets: Dr.15709.1.S1_at (Zebrafish Array)   NM_131064_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000136047
Ensembl peptide - ENSDARP00000156961
Ensembl peptide - ENSDARP00000096012
Ensembl peptide - ENSDARP00000116298
Ensembl peptide - ENSDARP00000118680
Ensembl peptide - ENSDARP00000118931
Ensembl peptide - ENSDARP00000120587
NCBI entrez gene - 30270     See in Manteia.
RefSeq - NM_131064
RefSeq Peptide - NP_571139
swissprot - B3DG61
swissprot - O73797
ZFIN ID - ZDB-GENE-990415-176
Ensembl - ENSDARG00000058961
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NGFENSGALG00000002556Gallus gallus
 NGFENSG00000134259Homo sapiens
 NgfENSMUSG00000027859Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ngfb / Q6YBR5 / nerve growth factor b (beta polypeptide) / NGF* / P01138* / P01139* / nerve growth factor* / Beta-nerve growth factor *ENSDARG0000001405044
ntf3 / neurotrophin 3 / P20181* / P20783*ENSDARG0000005904333
bdnf / brain-derived neurotrophic factor / P21237* / P23560*ENSDARG0000001881729


Protein motifs (from Interpro)
Interpro ID Name
 IPR002072  Nerve growth factor-related
 IPR019846  Nerve growth factor conserved site
 IPR020408  Nerve growth factor-like
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IBA
 biological_processGO:0045664 regulation of neuron differentiation IBA
 biological_processGO:0048812 neuron projection morphogenesis IBA
 cellular_componentGO:0005576 extracellular region IBA
 cellular_componentGO:0031410 cytoplasmic vesicle IBA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005163 nerve growth factor receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IBA


Pathways (from Reactome)
Pathway description
NGF processing
Frs2-mediated activation
ARMS-mediated activation
Retrograde neurotrophin signalling
TRKA activation by NGF
PI3K/AKT activation
NFG and proNGF binds to p75NTR
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Axonal growth stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000094673 rhoab / Q6DHM9 / ras homolog gene family, member Ab / RHOA* / Q9QUI0* / P61586* / ras homolog family member A*  / complex / reaction
 ENSDARG00000004586 ntrk1 / neurotrophic tyrosine kinase, receptor, type 1 / P04629* / Q3UFB7* / neurotrophic receptor tyrosine kinase 1* / High affinity nerve growth factor receptor *  / complex / reaction
 ENSDARG00000028058 traf6 / Q6IWL4 / TNF receptor-associated factor 6 / P70196* / Q9Y4K3*  / complex / reaction
 ENSDARG00000028699 crkl / v-crk avian sarcoma virus CT10 oncogene homolog-like / P46109* / P47941* / Crk-like protein * / CRK like proto-oncogene, adaptor protein*  / complex
 ENSDARG00000023600 sh3gl2a / SH3 domain containing GRB2 like 2a, endophilin A1 / Q99962* / SH3GL2* / Q62420* / SH3-domain GRB2-like 2* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex
 ENSDARG00000054087 irs1 / insulin receptor substrate 1 / P35568*  / complex
 ENSDARG00000055635 crk / v-crk avian sarcoma virus CT10 oncogene homolog / P46108* / Q64010* / Adapter molecule crk * / CRK proto-oncogene, adaptor protein*  / complex
 ENSDARG00000014050 ngfb / Q6YBR5 / nerve growth factor b (beta polypeptide) / NGF* / P01138* / P01139* / nerve growth factor* / Beta-nerve growth factor *  / reaction / complex
 ENSDARG00000062909 furina / furin (paired basic amino acid cleaving enzyme) a / FURIN* / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction
 ENSDARG00000045873 frs2a / fibroblast growth factor receptor substrate 2a / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / complex / reaction
 ENSDARG00000075282 irs2b / insulin receptor substrate 2b / IRS2* / Irs3* / P81122* / Q9Y4H2* / insulin receptor substrate 2*  / complex
 ENSDARG00000058961 ngfa / O73797 / nerve growth factor a (beta polypeptide) / NGF* / P01139* / P01138* / nerve growth factor* / Beta-nerve growth factor *  / reaction / complex
 ENSDARG00000018060 pik3r2 / phosphoinositide-3-kinase, regulatory subunit 2 (beta) / O00459* / O08908* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2* / Phosphatidylinositol 3-kinase regulator...  / reaction / complex
 ENSDARG00000075014 sqstm1 / sequestosome 1 / Q13501* / Q64337*  / complex / reaction
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / reaction / complex
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / reaction / complex
 ENSDARG00000038442 plcg1 / phospholipase C, gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex
 ENSDARG00000035152 ap2b1 / adaptor-related protein complex 2, beta 1 subunit / P63010* / Q9DBG3* / AP-2 complex subunit beta *  / complex
 ENSDARG00000002790 Q6NWK2 / ap2m1a / ap2m1b / adaptor-related protein complex 2, mu 1 subunit, b / AP2M1* / Q96CW1* / P84091* / AP-2 complex subunit mu * / adaptor related protein complex 2 mu 1 subunit*  / complex
 ENSDARG00000075253 pik3cb / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / complex / reaction
 ENSDARG00000037353 frs2b / fibroblast growth factor receptor substrate 2b / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / reaction / complex
 ENSDARG00000033899 ap2m1b / adaptor-related protein complex 2, mu 1 subunit, b / AP2M1* / Q96CW1* / P84091* / AP-2 complex subunit mu * / adaptor related protein complex 2 mu 1 subunit*  / complex
 ENSDARG00000045618 clta / clathrin, light chain A / P09496*  / complex
 ENSDARG00000026967 ap2s1 / adaptor-related protein complex 2, sigma 1 subunit / P53680* / P62743* / AP-2 complex subunit sigma *  / complex
 ENSDARG00000090716 cltcb / clathrin, heavy chain b (Hc) / CLTC* / Q00610* / clathrin heavy chain*  / complex
 ENSDARG00000021225 prkci / Q90XF2 / protein kinase C, iota / P41743* / Q62074*  / complex / reaction
 ENSDARG00000070971 furinb / furin (paired basic amino acid cleaving enzyme) b / FURIN* / P23188* / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction
 ENSDARG00000031116 dnal4a / dynein, axonemal, light chain 4a / DNAL4* / Q9DCM4* / O96015* / dynein axonemal light chain 4* / Dynein light chain 4, axonemal *  / reaction
 ENSDARG00000079123 ikbkb / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta / O14920* / inhibitor of kappaB kinase beta* / inhibitor of nuclear factor kappa B kinase subunit beta*  / reaction / complex
 ENSDARG00000088708 ngfra / nerve growth factor receptor a (TNFR superfamily, member 16) / NGFR* / P08138* / nerve growth factor receptor*  / reaction / complex
 ENSDARG00000025949 irak1 / interleukin-1 receptor-associated kinase 1 / P51617* / Q62406*  / complex
 ENSDARG00000088841 dnal4b / dynein, axonemal, light chain 4b / DNAL4* / Q9DCM4* / O96015* / dynein axonemal light chain 4* / Dynein light chain 4, axonemal *  / reaction
 ENSDARG00000089223 ngfrb / nerve growth factor receptor b / NGFR* / P08138* / nerve growth factor receptor*  / reaction / complex






 

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