ENSDARG00000023600


Danio rerio

Features
Gene ID: ENSDARG00000023600
  
Biological name :sh3gl2a
  
Synonyms : SH3 domain containing GRB2 like 2a, endophilin A1 / sh3gl2a
  
Possible biological names infered from orthology : Q62420 / Q99962 / SH3 domain containing GRB2 like 2, endophilin A1 / SH3-domain GRB2-like 2 / SH3GL2
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 26740718
Gene end: 26782573
  
Corresponding Affymetrix probe sets: Dr.3323.1.S1_at (Zebrafish Array)   NM_201116_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000085044
Ensembl peptide - ENSDARP00000127035
NCBI entrez gene - 394091     See in Manteia.
RefSeq - NM_201116
RefSeq Peptide - NP_957410
swissprot - Q803T6
swissprot - R4GEX2
ZFIN ID - ZDB-GENE-040121-3
Ensembl - ENSDARG00000023600
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q8AXV1ENSGALG00000015096Gallus gallus
 Q99962ENSG00000107295Homo sapiens
 Q62420ENSMUSG00000028488Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
sh3gl1b / SH3-domain GRB2-like 1b / Q99961* / SH3GL1* / Q62419* / SH3-domain GRB2-like 1* / SH3 domain containing GRB2 like 1, endophilin A2*ENSDARG0000000264266
sh3gl3a / SH3-domain GRB2-like 3a / Q99963* / SH3GL3* / endophilin-A3 isoform 3 * / SH3 domain containing GRB2 like 3, endophilin A3*ENSDARG0000001336061
sh3gl1a / SH3-domain GRB2-like 1a / Q99961* / SH3GL1* / Q62419* / SH3-domain GRB2-like 1* / SH3 domain containing GRB2 like 1, endophilin A2*ENSDARG0000006795860
SH3GL2 (1 of many) / SH3 domain containing GRB2 like 2, endophilin A1 / Q99962* / SH3GL2*ENSDARG0000003990156
sh3gl3b / SH3-domain GRB2-like 3b / Q99963* / SH3GL3* / endophilin-A3 isoform 3 * / SH3 domain containing GRB2 like 3, endophilin A3*ENSDARG0000000730256
sh3glb2b / SH3-domain GRB2-like endophilin B2b / Q9NR46* / Q8R3V5* / SH3GLB2* / SH3-domain GRB2-like endophilin B2* / SH3 domain containing GRB2 like, endophilin B2*ENSDARG0000003547028
sh3glb1b / SH3-domain GRB2-like endophilin B1b / Q9JK48* / Q9Y371* / SH3GLB1* / Endophilin-B1 * / SH3 domain containing GRB2 like, endophilin B1*ENSDARG0000001095626
sh3glb2a / SH3-domain GRB2-like endophilin B2a / Q9NR46* / Q8R3V5* / SH3GLB2* / SH3-domain GRB2-like endophilin B2* / SH3 domain containing GRB2 like, endophilin B2*ENSDARG0000000898325
sh3glb1a / SH3-domain GRB2-like endophilin B1a / Q9JK48* / Q9Y371* / SH3GLB1* / Endophilin-B1 * / SH3 domain containing GRB2 like, endophilin B1*ENSDARG0000004529424


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR004148  BAR domain
 IPR027267  AH/BAR domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 cellular_componentGO:0005737 cytoplasm IEA


Pathways (from Reactome)
Pathway description
Retrograde neurotrophin signalling
EGFR downregulation
MHC class II antigen presentation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
Recycling pathway of L1
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000005318 stam2 / signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 / O75886* / O88811* / signal transducing adaptor molecule 2*  / reaction / complex
 ENSDARG00000052739 egf / epidermal growth factor / P01132* / P01133* / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA.*  / reaction
 ENSDARG00000090716 cltcb / clathrin, heavy chain b (Hc) / CLTC* / Q00610* / clathrin heavy chain*  / reaction / complex
 ENSDARG00000026967 ap2s1 / adaptor-related protein complex 2, sigma 1 subunit / P53680* / P62743* / AP-2 complex subunit sigma *  / complex / reaction
 ENSDARG00000035152 ap2b1 / adaptor-related protein complex 2, beta 1 subunit / P63010* / Q9DBG3* / AP-2 complex subunit beta *  / reaction / complex
 ENSDARG00000045618 clta / clathrin, light chain A / P09496*  / complex / reaction
 ENSDARG00000002790 Q6NWK2 / ap2m1a / ap2m1b / adaptor-related protein complex 2, mu 1 subunit, b / AP2M1* / Q96CW1* / P84091* / AP-2 complex subunit mu * / adaptor related protein complex 2 mu 1 subunit*  / reaction / complex
 ENSDARG00000033899 ap2m1b / adaptor-related protein complex 2, mu 1 subunit, b / AP2M1* / Q96CW1* / P84091* / AP-2 complex subunit mu * / adaptor related protein complex 2 mu 1 subunit*  / complex / reaction
 ENSDARG00000023600 sh3gl2a / SH3 domain containing GRB2 like 2a, endophilin A1 / Q99962* / SH3GL2* / Q62420* / SH3-domain GRB2-like 2* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex
 ENSDARG00000014050 ngfb / Q6YBR5 / nerve growth factor b (beta polypeptide) / NGF* / P01138* / P01139* / nerve growth factor* / Beta-nerve growth factor *  / complex
 ENSDARG00000027552 mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction / complex
 ENSDARG00000004586 ntrk1 / neurotrophic tyrosine kinase, receptor, type 1 / P04629* / Q3UFB7* / neurotrophic receptor tyrosine kinase 1* / High affinity nerve growth factor receptor *  / complex
 ENSDARG00000009087 cd74a / CD74 molecule, major histocompatibility complex, class II invariant chain a / CD74* / P04233* / P04441* / CD74 molecule* / CD74 antigen (invariant polypeptide of major histocompatib...  / complex
 ENSDARG00000075853 sh3kbp1 / SH3-domain kinase binding protein 1 / Q8R550* / Q96B97* / SH3 domain containing kinase binding protein 1*  / complex
 ENSDARG00000058961 ngfa / O73797 / nerve growth factor a (beta polypeptide) / NGF* / P01139* / P01138* / nerve growth factor* / Beta-nerve growth factor *  / complex
 ENSDARG00000045544 hgfa / hepatocyte growth factor a / HGF* / P14210* / Q08048* / hepatocyte growth factor* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*  / reaction / complex
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex
 ENSDARG00000078216 eps15 / epidermal growth factor receptor pathway substrate 15 / P42566* / P42567* / Epidermal growth factor receptor substrate 15 *  / complex / reaction
 ENSDARG00000031116 dnal4a / dynein, axonemal, light chain 4a / DNAL4* / Q9DCM4* / O96015* / dynein axonemal light chain 4* / Dynein light chain 4, axonemal *  / reaction
 ENSDARG00000020960 hgs / hepatocyte growth factor-regulated tyrosine kinase substrate / O14964* / hepatocyte growth factor-regulated tyrosine kinase substrate isoform 2 *  / reaction / complex
 ENSDARG00000002127 stam / signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 / P70297* / Q92783* / signal transducing adaptor molecule*  / reaction / complex
 ENSDARG00000088841 dnal4b / dynein, axonemal, light chain 4b / DNAL4* / Q9DCM4* / O96015* / dynein axonemal light chain 4* / Dynein light chain 4, axonemal *  / reaction
 ENSDARG00000070903 met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / complex / reaction
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction






 

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