ENSDARG00000007302


Danio rerio

Features
Gene ID: ENSDARG00000007302
  
Biological name :sh3gl3b
  
Synonyms : SH3-domain GRB2-like 3b / sh3gl3b
  
Possible biological names infered from orthology : endophilin-A3 isoform 3 / Q99963 / SH3 domain containing GRB2 like 3, endophilin A3 / SH3GL3
  
Species: Danio rerio
  
Chr. number: 25
Strand: 1
Band:
Gene start: 19522954
Gene end: 19537323
  
Corresponding Affymetrix probe sets: Dr.12218.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000151600
Ensembl peptide - ENSDARP00000007836
Ensembl peptide - ENSDARP00000117769
NCBI entrez gene - 393150     See in Manteia.
swissprot - F1QYU2
swissprot - Q6TGT7
ZFIN ID - ZDB-GENE-040121-4
Ensembl - ENSDARG00000007302
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SH3GL3ENSGALG00000006045Gallus gallus
 Q99963ENSG00000140600Homo sapiens
 Sh3gl3ENSMUSG00000030638Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
sh3gl3a / SH3-domain GRB2-like 3a / Q99963* / SH3GL3* / endophilin-A3 isoform 3 * / SH3 domain containing GRB2 like 3, endophilin A3*ENSDARG0000001336055
sh3gl1b / SH3-domain GRB2-like 1b / Q99961* / SH3GL1* / Q62419* / SH3-domain GRB2-like 1* / SH3 domain containing GRB2 like 1, endophilin A2*ENSDARG0000000264251
sh3gl2a / SH3 domain containing GRB2 like 2a, endophilin A1 / Q99962* / SH3GL2* / Q62420* / SH3-domain GRB2-like 2* / SH3 domain containing GRB2 like 2, endophilin A1*ENSDARG0000002360050
sh3gl1a / SH3-domain GRB2-like 1a / Q99961* / SH3GL1* / Q62419* / SH3-domain GRB2-like 1* / SH3 domain containing GRB2 like 1, endophilin A2*ENSDARG0000006795849
SH3GL2 (1 of many) / SH3 domain containing GRB2 like 2, endophilin A1 / Q99962* / SH3GL2*ENSDARG0000003990133
sh3glb2b / SH3-domain GRB2-like endophilin B2b / Q9NR46* / Q8R3V5* / SH3GLB2* / SH3-domain GRB2-like endophilin B2* / SH3 domain containing GRB2 like, endophilin B2*ENSDARG0000003547022
sh3glb1b / SH3-domain GRB2-like endophilin B1b / Q9JK48* / Q9Y371* / SH3GLB1* / Endophilin-B1 * / SH3 domain containing GRB2 like, endophilin B1*ENSDARG0000001095621
sh3glb2a / SH3-domain GRB2-like endophilin B2a / Q9NR46* / Q8R3V5* / SH3GLB2* / SH3-domain GRB2-like endophilin B2* / SH3 domain containing GRB2 like, endophilin B2*ENSDARG0000000898321
sh3glb1a / SH3-domain GRB2-like endophilin B1a / Q9JK48* / Q9Y371* / SH3GLB1* / Endophilin-B1 * / SH3 domain containing GRB2 like, endophilin B1*ENSDARG0000004529421


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR004148  BAR domain
 IPR027267  AH/BAR domain superfamily
 IPR028501  Endophilin-A


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0072554 blood vessel lumenization IMP
 cellular_componentGO:0005737 cytoplasm IEA


Pathways (from Reactome)
Pathway description
EGFR downregulation
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood decreased fluid flow , abnormal
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 ZFA:0000014 dorsal aorta dorsal aorta decreased diameter , abnormal
dorsal aorta blood vessel lumenization decreased process quality , abnormal
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 ZFA:0000477 posterior cardinal vein posterior cardinal vein increased diameter , abnormal
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 ZFA:0009044 blood cell blood cell accumulation sinus venosus , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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