ENSG00000140600


Homo sapiens

Features
Gene ID: ENSG00000140600
  
Biological name :SH3GL3
  
Synonyms : Q99963 / SH3 domain containing GRB2 like 3, endophilin A3 / SH3GL3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q25.2
Gene start: 83447228
Gene end: 83618743
  
Corresponding Affymetrix probe sets: 205636_at (Human Genome U133 Plus 2.0 Array)   205637_s_at (Human Genome U133 Plus 2.0 Array)   211565_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000320092
Ensembl peptide - ENSP00000391372
Ensembl peptide - ENSP00000456249
NCBI entrez gene - 6457     See in Manteia.
OMIM - 603362
RefSeq - NM_001324184
RefSeq - NM_001324185
RefSeq - NM_001324186
RefSeq - NM_001324187
RefSeq - NM_003027
RefSeq - XM_017022486
RefSeq - NM_001301108
RefSeq - NM_001301109
RefSeq - NM_001324182
RefSeq - NM_001324183
RefSeq - XM_011521889
RefSeq - XM_011521891
RefSeq Peptide - NP_001288038
RefSeq Peptide - NP_001311112
RefSeq Peptide - NP_001311113
RefSeq Peptide - NP_001311114
RefSeq Peptide - NP_001311115
RefSeq Peptide - NP_001311116
RefSeq Peptide - NP_003018
RefSeq Peptide - NP_001288037
RefSeq Peptide - NP_001311111
swissprot - Q99963
swissprot - H3BRH8
Ensembl - ENSG00000140600
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sh3gl3aENSDARG00000013360Danio rerio
 sh3gl3bENSDARG00000007302Danio rerio
 SH3GL3ENSGALG00000006045Gallus gallus
 Sh3gl3ENSMUSG00000030638Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q99961 / SH3GL1 / SH3 domain containing GRB2 like 1, endophilin A2ENSG0000014198566
Q99962 / SH3GL2 / SH3 domain containing GRB2 like 2, endophilin A1ENSG0000010729565
Q9NR46 / SH3GLB2 / SH3 domain containing GRB2 like, endophilin B2ENSG0000014834124
Q9Y371 / SH3GLB1 / SH3 domain containing GRB2 like, endophilin B1ENSG0000009703324


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR004148  BAR domain
 IPR027267  AH/BAR domain superfamily
 IPR028501  Endophilin-A
 IPR032469  Endophilin-A3, BAR domain
 IPR035824  Endophilin-A, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007417 central nervous system development TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
EGFR downregulation
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
InlB-mediated entry of Listeria monocytogenes into host cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000140600 Q99963 / SH3GL3 / SH3 domain containing GRB2 like 3, endophilin A3  / complex






 

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