ENSG00000141985


Homo sapiens

Features
Gene ID: ENSG00000141985
  
Biological name :SH3GL1
  
Synonyms : Q99961 / SH3 domain containing GRB2 like 1, endophilin A2 / SH3GL1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.3
Gene start: 4360370
Gene end: 4400547
  
Corresponding Affymetrix probe sets: 201851_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000472640
Ensembl peptide - ENSP00000470792
Ensembl peptide - ENSP00000471260
Ensembl peptide - ENSP00000269886
Ensembl peptide - ENSP00000404568
Ensembl peptide - ENSP00000469766
NCBI entrez gene - 6455     See in Manteia.
OMIM - 601768
RefSeq - XM_017027146
RefSeq - NM_001199943
RefSeq - NM_001199944
RefSeq - NM_003025
RefSeq - XM_011528183
RefSeq Peptide - NP_001186873
RefSeq Peptide - NP_003016
RefSeq Peptide - NP_001186872
swissprot - Q6FGM0
swissprot - M0QYE0
swissprot - Q99961
swissprot - M0R0I3
swissprot - M0R2K6
Ensembl - ENSG00000141985
  
Related genetic diseases (OMIM): 601626 - Leukemia, acute myeloid, 601626
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sh3gl1aENSDARG00000067958Danio rerio
 sh3gl1bENSDARG00000002642Danio rerio
 Q8AXV0ENSGALG00000001121Gallus gallus
 Q62419ENSMUSG00000003200Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q99962 / SH3GL2 / SH3 domain containing GRB2 like 2, endophilin A1ENSG0000010729570
Q99963 / SH3GL3 / SH3 domain containing GRB2 like 3, endophilin A3ENSG0000014060064
Q9Y371 / SH3GLB1 / SH3 domain containing GRB2 like, endophilin B1ENSG0000009703326
Q9NR46 / SH3GLB2 / SH3 domain containing GRB2 like, endophilin B2ENSG0000014834125


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR004148  BAR domain
 IPR027267  AH/BAR domain superfamily
 IPR028501  Endophilin-A
 IPR035824  Endophilin-A, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007417 central nervous system development TAS
 biological_processGO:0016191 synaptic vesicle uncoating IEA
 biological_processGO:0098815 modulation of excitatory postsynaptic potential IEA
 biological_processGO:1900242 regulation of synaptic vesicle endocytosis IEA
 cellular_componentGO:0002102 podosome IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0019902 phosphatase binding IEA
 molecular_functionGO:0031697 beta-1 adrenergic receptor binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0051020 GTPase binding IEA


Pathways (from Reactome)
Pathway description
EGFR downregulation
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
InlB-mediated entry of Listeria monocytogenes into host cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000141985 Q99961 / SH3GL1 / SH3 domain containing GRB2 like 1, endophilin A2  / complex






 

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