ENSDARG00000045618


Danio rerio

Features
Gene ID: ENSDARG00000045618
  
Biological name :clta
  
Synonyms : clathrin, light chain A / clta
  
Possible biological names infered from orthology : P09496
  
Species: Danio rerio
  
Chr. number: 1
Strand: 1
Band:
Gene start: 12348213
Gene end: 12361930
  
Corresponding Affymetrix probe sets: Dr.26380.1.A1_at (Zebrafish Array)   NM_213045_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000067081
Ensembl peptide - ENSDARP00000114058
Ensembl peptide - ENSDARP00000113917
NCBI entrez gene - 406318     See in Manteia.
RefSeq - NM_213045
RefSeq Peptide - NP_998210
swissprot - E9QI07
swissprot - E9QDE6
swissprot - Q6P937
ZFIN ID - ZDB-GENE-040426-1986
Ensembl - ENSDARG00000045618
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CLTAENSGALG00000015326Gallus gallus
 CLTAENSG00000122705Homo sapiens
 CltaENSMUSG00000028478Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cltb / clathrin, light chain B / P09497* / Q6IRU5*ENSDARG0000005236854


Protein motifs (from Interpro)
Interpro ID Name
 IPR000996  Clathrin light chain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0072583 clathrin-dependent endocytosis IBA
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030125 clathrin vesicle coat IBA
 cellular_componentGO:0030130 clathrin coat of trans-Golgi network vesicle IEA
 cellular_componentGO:0030132 clathrin coat of coated pit IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0005198 structural molecule activity IBA
 molecular_functionGO:0032050 clathrin heavy chain binding IBA


Pathways (from Reactome)
Pathway description
Retrograde neurotrophin signalling
Gap junction degradation
Formation of annular gap junctions
MHC class II antigen presentation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
Recycling pathway of L1
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
VLDLR internalisation and degradation
LDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000002790 Q6NWK2 / ap2m1a / ap2m1b / adaptor-related protein complex 2, mu 1 subunit, b / AP2M1* / Q96CW1* / P84091* / AP-2 complex subunit mu * / adaptor related protein complex 2 mu 1 subunit*  / complex / reaction
 ENSDARG00000006257 vldlr / very low density lipoprotein receptor / P98155* / P98156*  / reaction / complex
 ENSDARG00000035152 ap2b1 / adaptor-related protein complex 2, beta 1 subunit / P63010* / Q9DBG3* / AP-2 complex subunit beta *  / complex / reaction
 ENSDARG00000004586 ntrk1 / neurotrophic tyrosine kinase, receptor, type 1 / P04629* / Q3UFB7* / neurotrophic receptor tyrosine kinase 1* / High affinity nerve growth factor receptor *  / complex
 ENSDARG00000009087 cd74a / CD74 molecule, major histocompatibility complex, class II invariant chain a / CD74* / P04233* / P04441* / CD74 molecule* / CD74 antigen (invariant polypeptide of major histocompatib...  / complex / reaction
 ENSDARG00000026967 ap2s1 / adaptor-related protein complex 2, sigma 1 subunit / P53680* / P62743* / AP-2 complex subunit sigma *  / complex / reaction
 ENSDARG00000027552 mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / complex / reaction
 ENSDARG00000096249 ap1m1 / adaptor-related protein complex 1, mu 1 subunit / Q9BXS5*  / complex
 ENSDARG00000110439 ap1s3a / adaptor-related protein complex 1, sigma 3 subunit, a / AP1S3* / Q96PC3* / adaptor related protein complex 1 sigma 3 subunit*  / complex
 ENSDARG00000090716 cltcb / clathrin, heavy chain b (Hc) / CLTC* / Q00610* / clathrin heavy chain*  / complex
 ENSDARG00000027966 ap1s3b / adaptor-related protein complex 1, sigma 3 subunit, b / AP1S3* / Q96PC3* / Q7TN05* / AP-1 complex subunit sigma-3 * / adaptor related protein complex 1 sigma 3 subunit*  / complex
 ENSDARG00000045618 clta / clathrin, light chain A / P09496*  / complex
 ENSDARG00000020621 ap1b1 / adaptor-related protein complex 1, beta 1 subunit / O35643* / Q10567* / Mus musculus adaptor protein complex AP-1, beta 1 subunit (Ap1b1), transcript variant 4, mRNA.*  / complex
 ENSDARG00000056803 ap1s1 / adaptor-related protein complex 1, sigma 1 subunit / P61966* / P61967* / AP-1 complex subunit sigma-1A *  / complex
 ENSDARG00000096454 ap1m2 / adaptor-related protein complex 1, mu 2 subunit / Q9Y6Q5*  / complex
 ENSDARG00000033899 ap2m1b / adaptor-related protein complex 2, mu 1 subunit, b / AP2M1* / Q96CW1* / P84091* / AP-2 complex subunit mu * / adaptor related protein complex 2 mu 1 subunit*  / reaction / complex
 ENSDARG00000023600 sh3gl2a / SH3 domain containing GRB2 like 2a, endophilin A1 / Q99962* / SH3GL2* / Q62420* / SH3-domain GRB2-like 2* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex / reaction
 ENSDARG00000014050 ngfb / Q6YBR5 / nerve growth factor b (beta polypeptide) / NGF* / P01138* / P01139* / nerve growth factor* / Beta-nerve growth factor *  / complex
 ENSDARG00000074185 pcsk9 / proprotein convertase subtilisin/kexin type 9 / Q8NBP7*  / reaction / complex
 ENSDARG00000058961 ngfa / O73797 / nerve growth factor a (beta polypeptide) / NGF* / P01139* / P01138* / nerve growth factor* / Beta-nerve growth factor *  / complex
 ENSDARG00000031116 dnal4a / dynein, axonemal, light chain 4a / DNAL4* / Q9DCM4* / O96015* / dynein axonemal light chain 4* / Dynein light chain 4, axonemal *  / reaction
 ENSDARG00000088841 dnal4b / dynein, axonemal, light chain 4b / DNAL4* / Q9DCM4* / O96015* / dynein axonemal light chain 4* / Dynein light chain 4, axonemal *  / reaction
 ENSDARG00000052368 cltb / clathrin, light chain B / P09497* / Q6IRU5*  / complex






 

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