ENSDARG00000075014


Danio rerio

Features
Gene ID: ENSDARG00000075014
  
Biological name :sqstm1
  
Synonyms : sequestosome 1 / sqstm1
  
Possible biological names infered from orthology : Q13501 / Q64337
  
Species: Danio rerio
  
Chr. number: 14
Strand: 1
Band:
Gene start: 16765992
Gene end: 16771405
  
Corresponding Affymetrix probe sets: Dr.923.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000117113
NCBI entrez gene - 406452     See in Manteia.
RefSeq - NM_001312913
RefSeq Peptide - NP_001299842
swissprot - F1Q5Z8
ZFIN ID - ZDB-GENE-040426-2204
Ensembl - ENSDARG00000075014
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SQSTM1ENSGALG00000035804Gallus gallus
 Q13501ENSG00000161011Homo sapiens
 Q64337ENSMUSG00000015837Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000270  PB1 domain
 IPR000433  Zinc finger, ZZ-type
 IPR009060  UBA-like superfamily
 IPR015940  Ubiquitin-associated domain
 IPR033741  Sequestosome-1, UBA domain
 IPR034866  Sequestosome-1, PB1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0010506 regulation of autophagy IGI
 cellular_componentGO:0005776 autophagosome IBA
 cellular_componentGO:0016235 aggresome IBA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0042802 identical protein binding IBA
 molecular_functionGO:0043130 ubiquitin binding IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Pink/Parkin Mediated Mitophagy
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism decreased mobility , abnormal
whole organism decreased life span , abnormal
Show

 ZFA:0009052 motor neuron motor neuron axon decreased length , abnormal
motor neuron axon decreased branchiness , abnormal
Show

 ZFA:0009327 neutrophil neutrophil response to bacterium process quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000028058 traf6 / Q6IWL4 / TNF receptor-associated factor 6 / P70196* / Q9Y4K3*  / complex / reaction
 ENSDARG00000014050 ngfb / Q6YBR5 / nerve growth factor b (beta polypeptide) / NGF* / P01138* / P01139* / nerve growth factor* / Beta-nerve growth factor *  / complex / reaction
 ENSDARG00000060348 map3k3 / mitogen-activated protein kinase kinase kinase 3 / Q61084* / Q99759*  / complex
 ENSDARG00000058961 ngfa / O73797 / nerve growth factor a (beta polypeptide) / NGF* / P01139* / P01138* / nerve growth factor* / Beta-nerve growth factor *  / reaction / complex
 ENSDARG00000079123 ikbkb / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta / O14920* / inhibitor of kappaB kinase beta* / inhibitor of nuclear factor kappa B kinase subunit beta*  / complex / reaction
 ENSDARG00000088708 ngfra / nerve growth factor receptor a (TNFR superfamily, member 16) / NGFR* / P08138* / nerve growth factor receptor*  / complex / reaction
 ENSDARG00000089223 ngfrb / nerve growth factor receptor b / NGFR* / P08138* / nerve growth factor receptor*  / complex / reaction
 ENSDARG00000021225 prkci / Q90XF2 / protein kinase C, iota / P41743* / Q62074*  / complex / reaction
 ENSDARG00000025949 irak1 / interleukin-1 receptor-associated kinase 1 / P51617* / Q62406*  / reaction / complex






 

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