ENSMUSG00000015837


Mus musculus

Features
Gene ID: ENSMUSG00000015837
  
Biological name :Sqstm1
  
Synonyms : Q64337 / Sequestosome-1 / Sqstm1
  
Possible biological names infered from orthology : Q13501
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B1.3
Gene start: 50199366
Gene end: 50210827
  
Corresponding Affymetrix probe sets: 10385572 (MoGene1.0st)   1442726_s_at (Mouse Genome 430 2.0 Array)   1444021_at (Mouse Genome 430 2.0 Array)   1450957_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000015981
Ensembl peptide - ENSMUSP00000099835
Ensembl peptide - ENSMUSP00000118662
Ensembl peptide - ENSMUSP00000120442
NCBI entrez gene - 18412     See in Manteia.
MGI - MGI:107931
RefSeq - NM_011018
RefSeq - NM_001290769
RefSeq Peptide - NP_001277698
RefSeq Peptide - NP_035148
swissprot - Q64337
swissprot - D3YZJ1
swissprot - F6VD69
Ensembl - ENSMUSG00000015837
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sqstm1ENSDARG00000075014Danio rerio
 SQSTM1ENSGALG00000035804Gallus gallus
 Q13501ENSG00000161011Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000270  PB1 domain
 IPR000433  Zinc finger, ZZ-type
 IPR009060  UBA-like superfamily
 IPR015940  Ubiquitin-associated domain
 IPR033741  Sequestosome-1, UBA domain
 IPR034866  Sequestosome-1, PB1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0000423 mitophagy IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002931 response to ischemia IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0006914 autophagy ISO
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007032 endosome organization IEA
 biological_processGO:0016236 macroautophagy IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035973 aggrephagy IEA
 biological_processGO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0044130 negative regulation of growth of symbiont in host IMP
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0061635 regulation of protein complex stability IEA
 biological_processGO:0061912 selective autophagy IEA
 biological_processGO:0098780 response to mitochondrial depolarisation IEA
 biological_processGO:1900273 positive regulation of long-term synaptic potentiation IMP
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IMP
 biological_processGO:1905719 protein localization to perinuclear region of cytoplasm IEA
 cellular_componentGO:0000407 phagophore assembly site IDA
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005776 autophagosome ISO
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016234 inclusion body IEA
 cellular_componentGO:0016235 aggresome IDA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0030017 sarcomere IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0044753 amphisome IEA
 cellular_componentGO:0044754 autolysosome IEA
 cellular_componentGO:0097225 sperm midpiece IDA
 cellular_componentGO:0097413 Lewy body IEA
 molecular_functionGO:0003712 transcription coregulator activity TAS
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IPI
 molecular_functionGO:0042169 SH2 domain binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043130 ubiquitin binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070530 K63-linked polyubiquitin modification-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Pink/Parkin Mediated Mitophagy
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Krt19tm1(cre/ERT)Ggu/Krt19tm1(cre/ERT)Ggu
Genetic Background: involves: C57BL/6 * CD-1

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Nhlrc1tm1Bmin/Nhlrc1tm1Bmin
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

 MP:0000162 lordosis "anteriorly convex curvature of the spine, "saddle back" " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62022]
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Allelic Composition: Nhlrc1tm1Bmin/Nhlrc1tm1Bmin
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Sqstm1tm1Keta/Sqstm1tm1Keta,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Sqstm1tm1Keta/Sqstm1tm1Keta,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Sqstm1tm1Keta/Sqstm1tm1Keta,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Spns2tm1a(KOMP)Wtsi/Wtsi

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Myo7admbo2/Myo7admbo2
Genetic Background: involves: C57BL/6J

Allelic Composition: Sqstm1tm1Keta/Sqstm1tm1Keta
Genetic Background: B6.129-Sqstm1tm1Keta

Allelic Composition: Sqstm1tm1.1Ewa/Sqstm1tm1.1Ewa,Tg(Nes-cre)1Kag/0
Genetic Background: involves: C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Myo7admbo2/Myo7admbo2
Genetic Background: involves: C57BL/6J

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Sqstm1tm1Keta/Sqstm1tm1Keta,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Isl1tm1(cre/Esr1*)Krc/Isl1tm2Sev
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Tg(Nes-cre)1Wme/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nhlrc1tm1Bmin/Nhlrc1tm1Bmin
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Myo7admbo2/Myo7admbo2
Genetic Background: involves: C57BL/6J

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krt19tm1(cre/ERT)Ggu/Krt19tm1(cre/ERT)Ggu
Genetic Background: involves: C57BL/6 * CD-1

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Sqstm1tm1Keta/Sqstm1tm1Keta,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Sqstm1tm1Keta/Sqstm1tm1Keta,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Sqstm1tm1Keta/Sqstm1tm1Keta,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0003212 susceptibility to age related obesity "increased probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Tg(Nes-cre)1Wme/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0003325 decreased liver function "reduced normal function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Sqstm1tm1Keta/Sqstm1tm1Keta,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Sqstm1tm1Keta/Sqstm1tm1Keta,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nhlrc1tm1Bmin/Nhlrc1tm1Bmin
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

 MP:0003786 premature aging "earlier than normal occurence of the normal signs of aging" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:97764]
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Allelic Composition: Nhlrc1tm1Bmin/Nhlrc1tm1Bmin
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

 MP:0003795 abnormal bone structure 
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Allelic Composition: Krt19tm1(cre/ERT)Ggu/Krt19tm1(cre/ERT)Ggu
Genetic Background: involves: C57BL/6 * CD-1

Allelic Composition: Sqstm1tm1.1Sral/Sqstm1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0003797 abnormal compact bone morphology "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Krt19tm1(cre/ERT)Ggu/Krt19tm1(cre/ERT)Ggu
Genetic Background: involves: C57BL/6 * CD-1

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Myo7admbo2/Myo7admbo2
Genetic Background: involves: C57BL/6J

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo7admbo2/Myo7admbo2
Genetic Background: involves: C57BL/6J

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Spns2tm1a(KOMP)Wtsi/Wtsi

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krt19tm1(cre/ERT)Ggu/Krt19tm1(cre/ERT)Ggu
Genetic Background: involves: C57BL/6 * CD-1

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krt19tm1(cre/ERT)Ggu/Krt19tm1(cre/ERT)Ggu
Genetic Background: involves: C57BL/6 * CD-1

Allelic Composition: Sqstm1tm1.1Sral/Sqstm1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gjb6tm1Kwi/Gjb6+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nhlrc1tm1Bmin/Nhlrc1tm1Bmin
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myo7admbo2/Myo7admbo2
Genetic Background: involves: C57BL/6J

Allelic Composition: Sqstm1tm1Keta/Sqstm1tm1Keta
Genetic Background: B6.129-Sqstm1tm1Keta

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Myo7admbo2/Myo7admbo2
Genetic Background: involves: C57BL/6J

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Sqstm1tm1Keta/Sqstm1tm1Keta,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Sqstm1tm1Keta/Sqstm1tm1Keta,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Spns2tm1a(KOMP)Wtsi/Wtsi

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Spns2tm1a(KOMP)Wtsi/Wtsi

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Sqstm1tm1Keta/Sqstm1tm1Keta
Genetic Background: B6.129-Sqstm1tm1Keta

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Nhlrc1tm1Bmin/Nhlrc1tm1Bmin
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Krt19tm1(cre/ERT)Ggu/Krt19tm1(cre/ERT)Ggu
Genetic Background: involves: C57BL/6 * CD-1

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gjb6tm1Kwi/Gjb6+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Sqstm1tm1Jjw/Sqstm1tm1Jjw
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Sqstm1tm1.1Sral/Sqstm1tm1.1Sral
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Sqstm1tm1.1Sral/Sqstm1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Gjb6tm1Kwi/Gjb6+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nhlrc1tm1Bmin/Nhlrc1tm1Bmin
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

 MP:0008947 increased neuron number "greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Sqstm1tm1Keta/Sqstm1tm1Keta
Genetic Background: B6.129-Sqstm1tm1Keta

 MP:0009118 increased white fat cell size "increase in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo7admbo2/Myo7admbo2
Genetic Background: involves: C57BL/6J

 MP:0009124 increased brown fat cell lipid droplet size "increase in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo7admbo2/Myo7admbo2
Genetic Background: involves: C57BL/6J

 MP:0009972 absent hippocampus pyramidal cells "absence of the projection neurons in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Sqstm1tm1Keta/Sqstm1tm1Keta,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0009975 absent cerebral cortex pyramidal cells "increased number of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Sqstm1tm1Keta/Sqstm1tm1Keta,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo7admbo2/Myo7admbo2
Genetic Background: involves: C57BL/6J

 MP:0010179 rough coat "coat does not have the usual smooth appearance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nhlrc1tm1Bmin/Nhlrc1tm1Bmin
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
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Allelic Composition: Nhlrc1tm1Bmin/Nhlrc1tm1Bmin
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

 MP:0010956 abnormal mitochondrial ATP synthesis coupled electron transport "anomaly in the transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane and mediated by multisubunit enzyme complexes known as complex I-IV" [GO:0042775, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo7admbo2/Myo7admbo2
Genetic Background: involves: C57BL/6J

 MP:0010957 abnormal aerobic respiration "any anomaly in the process of enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor" [GO:0009060]
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Allelic Composition: Myo7admbo2/Myo7admbo2
Genetic Background: involves: C57BL/6J

 MP:0011014 decreased core body temperature "reduced degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo7admbo2/Myo7admbo2
Genetic Background: involves: C57BL/6J

 MP:0011635 abnormal mitochondrial crista morphology "Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria" [GO:0030061]
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Allelic Composition: Myo7admbo2/Myo7admbo2
Genetic Background: involves: C57BL/6J

 MP:0011636 disorganized mitochondrial cristae "derangement of the pattern of the inward folds of the mitochondrial inner membrane" [MGI:csmith]
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Allelic Composition: Myo7admbo2/Myo7admbo2
Genetic Background: involves: C57BL/6J

 MP:0011699 abnormal brown adipose tissue thermogenesis "any anomaly in the process of heat production in brown adipocytes" [MGI:smb]
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Allelic Composition: Myo7admbo2/Myo7admbo2
Genetic Background: involves: C57BL/6J

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Sqstm1tm1Keta/Sqstm1tm1Keta
Genetic Background: B6.129-Sqstm1tm1Keta

Allelic Composition: Sqstm1tm1.1Ewa/Sqstm1tm1.1Ewa,Tg(Nes-cre)1Kag/0
Genetic Background: involves: C57BL/6J

 MP:0020411 increased abdominal adipose tissue amount "increase in amount of adipose tissue associated with internal organs" [MGI:anna]
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Allelic Composition: Sqstm1tm1.1Ewa/Sqstm1tm1.1Ewa,Tg(Nes-cre)1Kag/0
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000120 Ngfr / nerve growth factor receptor / P08138*  / reaction / complex
 ENSMUSG00000027859 Ngf / P01139 / Beta-nerve growth factor / P01138* / nerve growth factor*  / complex / reaction
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / complex / reaction
 ENSMUSG00000028549 Q9CQ82 / Itgb3bp / integrin beta 3 binding protein (beta3-endonexin) / Q13352* / integrin subunit beta 3 binding protein*  / complex / reaction
 ENSMUSG00000031392 Irak1 / Q62406 / Interleukin-1 receptor-associated kinase 1 / P51617*  / reaction / complex
 ENSMUSG00000020700 Map3k3 / Q61084 / Mitogen-activated protein kinase kinase kinase 3 / Q99759*  / complex
 ENSMUSG00000037643 Prkci / Q62074 / protein kinase C, iota / P41743*  / reaction / complex






 

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