ENSDARG00000059043


Danio rerio

Features
Gene ID: ENSDARG00000059043
  
Biological name :ntf3
  
Synonyms : neurotrophin 3 / ntf3
  
Possible biological names infered from orthology : P20181 / P20783
  
Species: Danio rerio
  
Chr. number: 4
Strand: -1
Band:
Gene start: 4397503
Gene end: 4431975
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000076483
NCBI entrez gene - 386825     See in Manteia.
RefSeq - NM_001327813
RefSeq Peptide - NP_001314742
swissprot - F1QR36
ZFIN ID - ZDB-GENE-031118-66
Ensembl - ENSDARG00000059043
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NTF3ENSGALG00000027299Gallus gallus
 NTF3ENSG00000185652Homo sapiens
 Ntf3ENSMUSG00000049107Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ngfa / O73797 / nerve growth factor a (beta polypeptide) / NGF* / P01139* / P01138* / nerve growth factor* / Beta-nerve growth factor *ENSDARG0000005896132
bdnf / brain-derived neurotrophic factor / P21237* / P23560*ENSDARG0000001881731
ngfb / Q6YBR5 / nerve growth factor b (beta polypeptide) / NGF* / P01138* / P01139* / nerve growth factor* / Beta-nerve growth factor *ENSDARG0000001405030


Protein motifs (from Interpro)
Interpro ID Name
 IPR002072  Nerve growth factor-related
 IPR015578  Neurotrophin-3
 IPR019846  Nerve growth factor conserved site
 IPR020408  Nerve growth factor-like
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0007422 peripheral nervous system development IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0043069 negative regulation of programmed cell death IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IBA
 biological_processGO:0045664 regulation of neuron differentiation IBA
 biological_processGO:0048812 neuron projection morphogenesis IBA
 cellular_componentGO:0005576 extracellular region IBA
 cellular_componentGO:0031410 cytoplasmic vesicle IBA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005165 neurotrophin receptor binding IEA
 molecular_functionGO:0005166 neurotrophin p75 receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IBA


Pathways (from Reactome)
Pathway description
NTF3 activates NTRK3 signaling
Activated NTRK3 signals through PLCG1
Activated NTRK3 signals through PI3K


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000077228 ntrk3a / neurotrophic tyrosine kinase, receptor, type 3a / NTRK3* / Q16288* / Q6VNS1* / NT-3 growth factor receptor * / neurotrophic receptor tyrosine kinase 3*  / complex
 ENSDARG00000059043 ntf3 / neurotrophin 3 / P20181* / P20783*  / complex
 ENSDARG00000086214 ntrk3b / neurotrophic tyrosine kinase, receptor, type 3b / NTRK3* / Q16288* / neurotrophic receptor tyrosine kinase 3*  / complex
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000038442 plcg1 / phospholipase C, gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr