ENSG00000185652


Homo sapiens

Features
Gene ID: ENSG00000185652
  
Biological name :NTF3
  
Synonyms : neurotrophin 3 / NTF3 / P20783
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: p13.31
Gene start: 5432112
Gene end: 5521536
  
Corresponding Affymetrix probe sets: 206706_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000328738
Ensembl peptide - ENSP00000397297
NCBI entrez gene - 4908     See in Manteia.
OMIM - 162660
RefSeq - XM_011520963
RefSeq - NM_001102654
RefSeq - NM_002527
RefSeq Peptide - NP_002518
RefSeq Peptide - NP_001096124
swissprot - P20783
Ensembl - ENSG00000185652
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ntf3ENSDARG00000059043Danio rerio
 NTF3ENSGALG00000027299Gallus gallus
 Ntf3ENSMUSG00000049107Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NGF / P01138 / nerve growth factorENSG0000013425938
BDNF / P23560 / brain derived neurotrophic factorENSG0000017669736
NTF4 / P34130 / neurotrophin 4ENSG0000022595031


Protein motifs (from Interpro)
Interpro ID Name
 IPR002072  Nerve growth factor-related
 IPR015578  Neurotrophin-3
 IPR019846  Nerve growth factor conserved site
 IPR020408  Nerve growth factor-like
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IDA
 biological_processGO:0002092 positive regulation of receptor internalization IDA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IDA
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0032148 activation of protein kinase B activity IDA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IDA
 biological_processGO:0042981 regulation of apoptotic process IGI
 biological_processGO:0043524 negative regulation of neuron apoptotic process IBA
 biological_processGO:0045664 regulation of neuron differentiation IBA
 biological_processGO:0048812 neuron projection morphogenesis IBA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050732 negative regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0050930 induction of positive chemotaxis IDA
 biological_processGO:0090630 activation of GTPase activity IDA
 biological_processGO:2000251 positive regulation of actin cytoskeleton reorganization IDA
 cellular_componentGO:0005576 extracellular region IBA
 cellular_componentGO:0031410 cytoplasmic vesicle IBA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005165 neurotrophin receptor binding IEA
 molecular_functionGO:0005166 neurotrophin p75 receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IDA
 molecular_functionGO:0042056 chemoattractant activity IDA


Pathways (from Reactome)
Pathway description
NTF3 activates NTRK2 (TRKB) signaling
NTF3 activates NTRK3 signaling
Signaling by NTRK3 (TRKC)
Activated NTRK3 signals through PLCG1
Activated NTRK3 signals through RAS
Activated NTRK3 signals through PI3K


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / reaction / complex
 ENSG00000148053 NTRK2 / Q16620 / neurotrophic receptor tyrosine kinase 2  / reaction / complex
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction / complex
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex
 ENSG00000185652 NTF3 / P20783 / neurotrophin 3  / complex
 ENSG00000140538 NTRK3 / Q16288 / neurotrophic receptor tyrosine kinase 3  / reaction / complex
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / complex / reaction






 

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