ENSDARG00000067537


Danio rerio

Features
Gene ID: ENSDARG00000067537
  
Biological name :pcsk5a
  
Synonyms : pcsk5a / proprotein convertase subtilisin/kexin type 5a
  
Possible biological names infered from orthology : PCSK5 / proprotein convertase subtilisin/kexin type 5 / Q04592 / Q92824
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 55265274
Gene end: 55349429
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000079749
Ensembl peptide - ENSDARP00000104646
swissprot - A2BHH6
swissprot - F1R175
ZFIN ID - ZDB-GENE-060531-130
Ensembl - ENSDARG00000067537
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000033256Gallus gallus
 ENSGALG00000015164Gallus gallus
 PCSK5ENSG00000099139Homo sapiens
 Pcsk5ENSMUSG00000024713Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pcsk5b / proprotein convertase subtilisin/kexin type 5b / PCSK5* / Q92824* / proprotein convertase subtilisin/kexin type 5*ENSDARG0000006051825
furina / furin (paired basic amino acid cleaving enzyme) a / FURIN* / P09958* / furin, paired basic amino acid cleaving enzyme*ENSDARG0000006290919
furinb / furin (paired basic amino acid cleaving enzyme) b / FURIN* / P23188* / P09958* / furin, paired basic amino acid cleaving enzyme*ENSDARG0000007097119
pcsk1 / proprotein convertase subtilisin/kexin type 1 / P29120* / P63239* / Neuroendocrine convertase 1 *ENSDARG0000000260016
pcsk2 / proprotein convertase subtilisin/kexin type 2 / P16519*ENSDARG0000001945114
pcsk7 / proprotein convertase subtilisin/kexin type 7 / Q16549*ENSDARG0000006996814
pcsk6 / proprotein convertase subtilisin/kexin type 6 / P29122*ENSDARG0000010457412


Protein motifs (from Interpro)
Interpro ID Name
 IPR000209  Peptidase S8/S53 domain
 IPR000742  EGF-like domain
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR002884  P domain
 IPR006212  Furin-like repeat
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR015500  Peptidase S8, subtilisin-related
 IPR022398  Peptidase S8, subtilisin, His-active site
 IPR023827  Peptidase S8, subtilisin, Asp-active site
 IPR023828  Peptidase S8, subtilisin, Ser-active site
 IPR032778  Growth factor receptor domain 4
 IPR032815  Peptidase S8, pro-domain
 IPR034182  Kexin/furin catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0048884 neuromast development IMP
 biological_processGO:0048899 anterior lateral line development IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
NGF processing


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000243 neuromast neuromast decreased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased size , abnormal
Show

 ZFA:0001115 trunk trunk curved , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved , abnormal
Show

 ZFA:0001469 lateral line lateral line morphology , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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