ENSDARG00000109371


Danio rerio

Features
Gene ID: ENSDARG00000109371
  
Biological name :pdgfaa
  
Synonyms : pdgfaa / platelet-derived growth factor alpha polypeptide a
  
Possible biological names infered from orthology : P04085 / PDGFA / platelet derived growth factor subunit A
  
Species: Danio rerio
  
Chr. number: 22
Strand: -1
Band:
Gene start: 26085343
Gene end: 26100282
  
Corresponding Affymetrix probe sets: Dr.10074.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000135075
NCBI entrez gene - 103909601     See in Manteia.
RefSeq - XM_009296413
RefSeq - XM_021473515
swissprot - A5PMP7
ZFIN ID - ZDB-GENE-030918-2
Ensembl - ENSDARG00000109371
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PDGFAENSGALG00000003642Gallus gallus
 PDGFAENSG00000197461Homo sapiens
 PdgfaENSMUSG00000025856Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pdgfaa / platelet-derived growth factor alpha polypeptide a / PDGFA* / P04085* / platelet derived growth factor subunit A*ENSDARG00000110069100
pdgfab / platelet-derived growth factor alpha polypeptide b / PDGFA* / P04085* / platelet derived growth factor subunit A*ENSDARG0000009857860
pdgfbb / platelet-derived growth factor beta polypeptide b / PDGFB* / P01127* / platelet derived growth factor subunit B* / platelet derived growth factor, B polypeptide*ENSDARG000000381393
pdgfba / platelet-derived growth factor beta polypeptide a / PDGFB* / P01127* / platelet derived growth factor subunit B* / platelet derived growth factor, B polypeptide*ENSDARG000000867783


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR006782  Platelet-derived growth factor, N-terminal
 IPR023581  Platelet-derived growth factor, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003261 cardiac muscle progenitor cell migration to the midline involved in heart field formation IMP
 biological_processGO:0007275 multicellular organism development IEP
 biological_processGO:0007596 blood coagulation IBA
 biological_processGO:0008284 positive regulation of cell proliferation IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IBA
 biological_processGO:0030335 positive regulation of cell migration IBA
 biological_processGO:0031954 positive regulation of protein autophosphorylation IBA
 biological_processGO:0043406 positive regulation of MAP kinase activity IBA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IBA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Non-integrin membrane-ECM interactions
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001405 ethmoid cartilage ethmoid cartilage aplastic , abnormal
Show

 ZFA:0001507 trabecula cranii trabecula cranii malformed , abnormal
Show

 ZFA:0001508 trabecula communis trabecula communis cleft , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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