ENSDARG00000010785


Danio rerio

Features
Gene ID: ENSDARG00000010785
  
Biological name :thbs1b
  
Synonyms : thbs1b / thrombospondin 1b
  
Possible biological names infered from orthology : P07996 / THBS1 / thrombospondin 1
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 29036328
Gene end: 29052391
  
Corresponding Affymetrix probe sets: Dr.2712.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000145410
Ensembl peptide - ENSDARP00000012255
Ensembl peptide - ENSDARP00000120705
NCBI entrez gene - 561901     See in Manteia.
swissprot - F1QEE7
swissprot - F1QL35
ZFIN ID - ZDB-GENE-020708-1
Ensembl - ENSDARG00000010785
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 THBS1ENSGALG00000009626Gallus gallus
 THBS1ENSG00000137801Homo sapiens
 Thbs1ENSMUSG00000040152Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
thbs2a / thrombospondin 2a / THBS2* / Q03350* / P35442* / thrombospondin 2*ENSDARG0000006041063
thbs2b / thrombospondin 2b / THBS2* / Q03350* / P35442* / thrombospondin 2*ENSDARG0000007381062
thbs3a / thrombospondin 3a / THBS3* / Q05895* / P49746* / thrombospondin 3*ENSDARG0000007764134
thbs4a / thrombospondin 4a / THBS4* / P35443* / thrombospondin 4*ENSDARG0000010277733
thbs4b / thrombospondin 4b / THBS4* / Q9Z1T2* / P35443* / thrombospondin 4*ENSDARG0000002007233
Q1L8P7 / thbs3b / thrombospondin 3b / THBS3* / Q05895* / P49746* / thrombospondin 3*ENSDARG0000001206033
COMP / si:ch211-43f4.1 / P49747* / Q9R0G6* / cartilage oligomeric matrix protein*ENSDARG0000009843132


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001007  VWFC domain
 IPR001791  Laminin G domain
 IPR001881  EGF-like calcium-binding domain
 IPR003367  Thrombospondin, type 3-like repeat
 IPR008859  Thrombospondin, C-terminal
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR017897  Thrombospondin, type 3 repeat
 IPR028499  Thrombospondin-1
 IPR028974  TSP type-3 repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0030198 extracellular matrix organization IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0050840 extracellular matrix binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Signaling by PDGF
Integrin cell surface interactions
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000010785 thbs1b / thrombospondin 1b / THBS1* / P07996* / thrombospondin 1*  / complex
 ENSDARG00000071863 itgb1a / integrin, beta 1a / ITGB1* / P05556* / P09055* / Integrin beta-1 * / integrin subunit beta 1*  / complex / reaction
 ENSDARG00000012824 itga3b / integrin, alpha 3b / ITGA3* / P26006* / Q62470* / integrin subunit alpha 3* / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain*  / complex / reaction
 ENSDARG00000103056 itga4 / integrin alpha 4 / P13612* / integrin subunit alpha 4*  / complex / reaction
 ENSDARG00000037917 itga3a / integrin, alpha 3a / ITGA3* / P26006* / Q62470* / integrin subunit alpha 3* / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain*  / complex / reaction
 ENSDARG00000038139 pdgfbb / platelet-derived growth factor beta polypeptide b / PDGFB* / P01127* / platelet derived growth factor subunit B* / platelet derived growth factor, B polypeptide*  / complex / reaction
 ENSDARG00000110069 pdgfaa / platelet-derived growth factor alpha polypeptide a / PDGFA* / P04085* / platelet derived growth factor subunit A*  / complex / reaction
 ENSDARG00000086778 pdgfba / platelet-derived growth factor beta polypeptide a / PDGFB* / P01127* / platelet derived growth factor subunit B* / platelet derived growth factor, B polypeptide*  / complex / reaction






 

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