ENSGALG00000009626


Gallus gallus

Features
Gene ID: ENSGALG00000009626
  
Biological name :THBS1
  
Synonyms : THBS1 / thrombospondin-1 precursor
  
Possible biological names infered from orthology : P07996 / thrombospondin 1
  
Species: Gallus gallus
  
Chr. number: 5
Strand: -1
Band:
Gene start: 29636380
Gene end: 29652162
  
Corresponding Affymetrix probe sets: Gga.10300.1.S1_s_at (Chicken Array)   Gga.3448.1.S1_at (Chicken Array)   GgaAffx.22987.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000015662
Ensembl peptide - ENSGALP00000060733
NCBI entrez gene - 373987     See in Manteia.
RefSeq - NM_001199453
RefSeq Peptide - NP_001186382
swissprot - F1P0J8
Ensembl - ENSGALG00000009626
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 thbs1bENSDARG00000010785Danio rerio
 THBS1ENSG00000137801Homo sapiens
 Thbs1ENSMUSG00000040152Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
THBS2 / thrombospondin-2 precursor / P35442* / Q03350* / thrombospondin 2*ENSGALG0000001120063
THBS4 / Gallus gallus thrombospondin 4 (THBS4), mRNA. / P35443* / Q9Z1T2* / thrombospondin 4*ENSGALG0000001480433
COMP / cartilage oligomeric matrix protein / P49747* / Q9R0G6*ENSGALG0000000328331


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001007  VWFC domain
 IPR001791  Laminin G domain
 IPR001881  EGF-like calcium-binding domain
 IPR003367  Thrombospondin, type 3-like repeat
 IPR008859  Thrombospondin, C-terminal
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR017897  Thrombospondin, type 3 repeat
 IPR028499  Thrombospondin-1
 IPR028974  TSP type-3 repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IEA
 biological_processGO:0001953 negative regulation of cell-matrix adhesion IEA
 biological_processGO:0002040 sprouting angiogenesis IEA
 biological_processGO:0002544 chronic inflammatory response IEA
 biological_processGO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IEA
 biological_processGO:0002605 negative regulation of dendritic cell antigen processing and presentation IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0010596 negative regulation of endothelial cell migration IEA
 biological_processGO:0010748 negative regulation of plasma membrane long-chain fatty acid transport IEA
 biological_processGO:0010751 negative regulation of nitric oxide mediated signal transduction IEA
 biological_processGO:0010754 negative regulation of cGMP-mediated signaling IEA
 biological_processGO:0010757 negative regulation of plasminogen activation IEA
 biological_processGO:0010763 positive regulation of fibroblast migration IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0018149 peptide cross-linking IEA
 biological_processGO:0030194 positive regulation of blood coagulation IEA
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0030823 obsolete regulation of cGMP metabolic process IEA
 biological_processGO:0032026 response to magnesium ion IEA
 biological_processGO:0032695 negative regulation of interleukin-12 production IEA
 biological_processGO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042535 positive regulation of tumor necrosis factor biosynthetic process IEA
 biological_processGO:0043032 positive regulation of macrophage activation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0043652 engulfment of apoptotic cell IEA
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050921 positive regulation of chemotaxis IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0051918 negative regulation of fibrinolysis IEA
 biological_processGO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IEA
 biological_processGO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IEA
 biological_processGO:2000353 positive regulation of endothelial cell apoptotic process IEA
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2001027 negative regulation of endothelial cell chemotaxis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005577 fibrinogen complex IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0031091 platelet alpha granule IEA
 molecular_functionGO:0001786 phosphatidylserine binding IEA
 molecular_functionGO:0001968 fibronectin binding IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0017134 fibroblast growth factor binding IEA
 molecular_functionGO:0030169 low-density lipoprotein particle binding IEA
 molecular_functionGO:0043236 laminin binding IEA
 molecular_functionGO:0050840 extracellular matrix binding IEA
 molecular_functionGO:0070051 fibrinogen binding IEA
 molecular_functionGO:0070052 collagen V binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Signaling by PDGF
Integrin cell surface interactions
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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