ENSG00000136943


Homo sapiens

Features
Gene ID: ENSG00000136943
  
Biological name :CTSV
  
Synonyms : cathepsin V / CTSV / O60911
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q22.33
Gene start: 97029679
Gene end: 97039643
  
Corresponding Affymetrix probe sets: 210074_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000445052
Ensembl peptide - ENSP00000259470
NCBI entrez gene - 1515     See in Manteia.
OMIM - 603308
RefSeq - NM_001201575
RefSeq - NM_001333
RefSeq Peptide - NP_001188504
RefSeq Peptide - NP_001324
swissprot - O60911
swissprot - A0A024R141
Ensembl - ENSG00000136943
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctslbENSDARG00000039173Danio rerio
 ctslbENSDARG00000074306Danio rerio
 ctsllENSDARG00000011701Danio rerio
 MGC174155ENSDARG00000095072Danio rerio
 si:dkey-239j18.2ENSDARG00000095254Danio rerio
 si:dkey-239j18.3ENSDARG00000089806Danio rerio
 si:dkey-269i1.4ENSDARG00000095744Danio rerio
 si:dkey-269i1.4ENSDARG00000100833Danio rerio
 si:dkey-26g8.4ENSDARG00000087651Danio rerio
 si:dkey-26g8.5ENSDARG00000089750Danio rerio
 zgc:174153ENSDARG00000079376Danio rerio
 zgc:174154ENSDARG00000075527Danio rerio
 zgc:174855ENSDARG00000094559Danio rerio
 CTSVENSGALG00000012610Gallus gallus
 CtslENSMUSG00000021477Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CTSL / P07711 / cathepsin LENSG0000013504777
CTSK / P43235 / cathepsin KENSG0000014338750
CTSS / P25774 / cathepsin SENSG0000016313149
CTSH / P09668 / cathepsin HENSG0000010381139
CTSF / Q9UBX1 / cathepsin FENSG0000017408035
CTSW / P56202 / cathepsin WENSG0000017254332


Protein motifs (from Interpro)
Interpro ID Name
 IPR000169  Cysteine peptidase, cysteine active site
 IPR000668  Peptidase C1A, papain C-terminal
 IPR013128  Peptidase C1A
 IPR013201  Cathepsin propeptide inhibitor domain (I29)
 IPR025660  Cysteine peptidase, histidine active site
 IPR025661  Cysteine peptidase, asparagine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0009267 cellular response to starvation IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010259 multicellular organism aging IEA
 biological_processGO:0010839 negative regulation of keratinocyte proliferation IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0016540 protein autoprocessing IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0021675 nerve development IEA
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0031069 hair follicle morphogenesis IEA
 biological_processGO:0034698 response to gonadotropin IEA
 biological_processGO:0045616 regulation of keratinocyte differentiation TAS
 biological_processGO:0046697 decidualization IEA
 biological_processGO:0048102 autophagic cell death IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IBA
 biological_processGO:0060008 Sertoli cell differentiation IEA
 biological_processGO:1990834 response to odorant IEA
 biological_processGO:2000249 regulation of actin cytoskeleton reorganization IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IBA
 cellular_componentGO:0005773 vacuole IEA
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043202 lysosomal lumen TAS
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0045177 apical part of cell IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004177 aminopeptidase activity IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity TAS
 molecular_functionGO:0004252 serine-type endopeptidase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016807 cysteine-type carboxypeptidase activity IEA
 molecular_functionGO:0030984 kininogen binding IEA
 molecular_functionGO:0042277 peptide binding IEA
 molecular_functionGO:0042393 histone binding IEA


Pathways (from Reactome)
Pathway description
Endosomal/Vacuolar pathway
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000137673 MMP7 / P09237 / matrix metallopeptidase 7  / reaction
 ENSG00000137745 MMP13 / P45452 / matrix metallopeptidase 13  / reaction
 ENSG00000197641 Q9UIV8 / SERPINB13 / serpin family B member 13  / complex / reaction






 

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