ENSG00000103811


Homo sapiens

Features
Gene ID: ENSG00000103811
  
Biological name :CTSH
  
Synonyms : cathepsin H / CTSH / P09668
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q25.1
Gene start: 78921058
Gene end: 78949574
  
Corresponding Affymetrix probe sets: 202295_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000435329
Ensembl peptide - ENSP00000431879
Ensembl peptide - ENSP00000483303
Ensembl peptide - ENSP00000220166
Ensembl peptide - ENSP00000432935
Ensembl peptide - ENSP00000432893
NCBI entrez gene - 1512     See in Manteia.
OMIM - 116820
RefSeq - XM_017021952
RefSeq - NM_001319137
RefSeq - NM_004390
RefSeq - XM_005254181
RefSeq - XM_017021951
RefSeq Peptide - NP_001306066
RefSeq Peptide - NP_004381
swissprot - E9PN60
swissprot - E9PKT6
swissprot - A0A0B4J217
swissprot - P09668
swissprot - A0A087X0D5
swissprot - E9PN84
Ensembl - ENSG00000103811
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctshENSDARG00000041108Danio rerio
 CTSHENSGALG00000033557Gallus gallus
 CtshENSMUSG00000032359Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CTSV / O60911 / cathepsin VENSG0000013694339
CTSK / P43235 / cathepsin KENSG0000014338739
CTSL / P07711 / cathepsin LENSG0000013504738
CTSS / P25774 / cathepsin SENSG0000016313135
CTSF / Q9UBX1 / cathepsin FENSG0000017408032
CTSW / P56202 / cathepsin WENSG0000017254329


Protein motifs (from Interpro)
Interpro ID Name
 IPR000169  Cysteine peptidase, cysteine active site
 IPR000668  Peptidase C1A, papain C-terminal
 IPR013128  Peptidase C1A
 IPR013201  Cathepsin propeptide inhibitor domain (I29)
 IPR025660  Cysteine peptidase, histidine active site
 IPR025661  Cysteine peptidase, asparagine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001656 metanephros development ISS
 biological_processGO:0001913 T cell mediated cytotoxicity IEA
 biological_processGO:0002250 adaptive immune response IEP
 biological_processGO:0002764 immune response-regulating signaling pathway IDA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010634 positive regulation of epithelial cell migration IEA
 biological_processGO:0010813 neuropeptide catabolic process IDA
 biological_processGO:0010815 bradykinin catabolic process IDA
 biological_processGO:0010952 positive regulation of peptidase activity IDA
 biological_processGO:0019882 antigen processing and presentation TAS
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0031638 zymogen activation IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0032526 response to retinoic acid IEA
 biological_processGO:0033619 membrane protein proteolysis IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043129 surfactant homeostasis IDA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IBA
 biological_processGO:0060448 dichotomous subdivision of terminal units involved in lung branching IEA
 biological_processGO:0070371 ERK1 and ERK2 cascade IDA
 biological_processGO:0097067 cellular response to thyroid hormone stimulus IEP
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0097208 alveolar lamellar body IDA
 cellular_componentGO:0097486 multivesicular body lumen TAS
 cellular_componentGO:1904724 tertiary granule lumen TAS
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004177 aminopeptidase activity IDA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process IEA
 molecular_functionGO:0016505 peptidase activator activity involved in apoptotic process IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030108 HLA-A specific activating MHC class I receptor activity IDA
 molecular_functionGO:0070324 thyroid hormone binding IDA


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation
Surfactant metabolism
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000504 Abnormality of vision "Abnormality of eyesight (visual perception)." [HPO:curators]
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 HP:0000738 Hallucinations 
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 HP:0001279 Syncope "Syncope refers to a generalized weakness of muscles with loss of postural tone, inability to stand upright, and loss of consciousness. Once the patient is in a horizontal position, blood flow to the brain is no longer hindered by gravitation and consciousness is regained. Unconsciousness usually lasts for seconds to minutes. Headache and drowsiness (which usually follow seizures) do not follow a syncopal attack. Syncope results from a sudden impairment of brain metabolism usually due to a reduction in cerebral blood flow. This term refers to an abnormally increased disposition to syncope." [HPO:curators]
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 HP:0001350 Slurred speech 
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 HP:0001513 Obesity "A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY)." [MeSH:D009765]
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 HP:0002189 Excessive daytime sleepiness 
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 HP:0002494 Abnormal rapid eye movement (REM) sleep "Abnormality of REM sleep. Phases of REM sleep are characterized by desynchronized EEG patterns, increases in heart rate and blood pressure, sympathetic activation, and a profound loss of muscle tonus except for the eye and middle-ear muscles. There are then phases of rapid eye movements." [HPO:curators]
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 HP:0002524 Cataplexy 
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 HP:0010534 Transient global amnesia "A paroxysmal, transient loss of memory function with preservation of immediate recall and remote memory but with a severe impairment of memory for recent events and ability to retain new information." [HPO:curators]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000103811 CTSH / P09668 / cathepsin H  / complex






 

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