ENSG00000163131


Homo sapiens

Features
Gene ID: ENSG00000163131
  
Biological name :CTSS
  
Synonyms : cathepsin S / CTSS / P25774
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q21.3
Gene start: 150730196
Gene end: 150765957
  
Corresponding Affymetrix probe sets: 202901_x_at (Human Genome U133 Plus 2.0 Array)   202902_s_at (Human Genome U133 Plus 2.0 Array)   232617_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000408414
Ensembl peptide - ENSP00000475557
Ensembl peptide - ENSP00000475812
Ensembl peptide - ENSP00000357981
Ensembl peptide - ENSP00000475176
NCBI entrez gene - 1520     See in Manteia.
OMIM - 116845
RefSeq - NM_001199739
RefSeq - NM_004079
RefSeq Peptide - NP_001186668
RefSeq Peptide - NP_004070
swissprot - P25774
swissprot - U3KPS4
swissprot - U3KQE7
Ensembl - ENSG00000163131
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctss2.1ENSDARG00000074656Danio rerio
 ctss2.2ENSDARG00000013771Danio rerio
 CTSSENSGALG00000000775Gallus gallus
 CtssENSMUSG00000038642Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CTSK / P43235 / cathepsin KENSG0000014338755
CTSV / O60911 / cathepsin VENSG0000013694350
CTSL / P07711 / cathepsin LENSG0000013504749
CTSH / P09668 / cathepsin HENSG0000010381135
CTSF / Q9UBX1 / cathepsin FENSG0000017408030
CTSW / P56202 / cathepsin WENSG0000017254329


Protein motifs (from Interpro)
Interpro ID Name
 IPR000169  Cysteine peptidase, cysteine active site
 IPR000668  Peptidase C1A, papain C-terminal
 IPR013128  Peptidase C1A
 IPR013201  Cathepsin propeptide inhibitor domain (I29)
 IPR025660  Cysteine peptidase, histidine active site
 IPR025661  Cysteine peptidase, asparagine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002224 toll-like receptor signaling pathway TAS
 biological_processGO:0002250 adaptive immune response IEP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0010447 response to acidic pH IDA
 biological_processGO:0016485 protein processing IDA
 biological_processGO:0019882 antigen processing and presentation TAS
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0030574 collagen catabolic process IDA
 biological_processGO:0034769 basement membrane disassembly IDA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0048002 antigen processing and presentation of peptide antigen IDA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IDA
 biological_processGO:0097067 cellular response to thyroid hormone stimulus IEP
 biological_processGO:2001259 positive regulation of cation channel activity IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0036021 endolysosome lumen TAS
 cellular_componentGO:0043202 lysosomal lumen TAS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:1904724 tertiary granule lumen TAS
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0001968 fibronectin binding IPI
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IDA
 molecular_functionGO:0004252 serine-type endopeptidase activity TAS
 molecular_functionGO:0005518 collagen binding IDA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043236 laminin binding IDA
 molecular_functionGO:0043394 proteoglycan binding IPI


Pathways (from Reactome)
Pathway description
Endosomal/Vacuolar pathway
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000142798 HSPG2 / P98160 / heparan sulfate proteoglycan 2  / reaction
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / reaction
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / reaction
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / reaction
 ENSG00000019582 CD74 / P04233 / CD74 molecule  / reaction
 ENSG00000239732 TLR9 / Q9NR96 / toll like receptor 9  / reaction
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / reaction






 

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