ENSDARG00000074656


Danio rerio

Features
Gene ID: ENSDARG00000074656
  
Biological name :ctss2.1
  
Synonyms : cathepsin S, ortholog2, tandem duplicate 1 / ctss2.1
  
Possible biological names infered from orthology : cathepsin S / CTSS / O70370 / P25774
  
Species: Danio rerio
  
Chr. number: 16
Strand: 1
Band:
Gene start: 29509133
Gene end: 29513434
  
Corresponding Affymetrix probe sets: Dr.24219.5.S1_at (Zebrafish Array)   NM_001024409_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000099159
NCBI entrez gene - 554157     See in Manteia.
RefSeq - NM_001024409
RefSeq Peptide - NP_001019580
swissprot - Q502A6
ZFIN ID - ZDB-GENE-050522-559
Ensembl - ENSDARG00000074656
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CTSSENSGALG00000000775Gallus gallus
 CTSSENSG00000163131Homo sapiens
 CtssENSMUSG00000038642Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ctss2.2 / cathepsin S, ortholog 2, tandem duplicate 2 / CTSS* / O70370* / P25774* / cathepsin S*ENSDARG0000001377179
ctsk / cathepsin K / P43235* / P55097*ENSDARG0000004025151
ctsla / cathepsin LaENSDARG0000000783648
ctss1 / cathepsin S, ortholog 1ENSDARG0000003694047
ctsll / cathepsin L, like / Ctsr* / Ctsq* / Ctsm* / CTSL* / Ctsj* / Cts8* / Cts6* / Cts7* / CTSV* / Cts3* / Q91ZF2* / Q9R014* / Q9JIA9* / Ctsll3* / O60911* / P06797* / P07711* / Q80UB0* / Q...ENSDARG0000001170147
ctslb / cathepsin Lb / Ctsr* / Ctsq* / Ctsm* / CTSL* / Ctsj* / Cts8* / Cts6* / Cts7* / CTSV* / Cts3* / Q91ZF2* / Q9R014* / Q9JIA9* / Ctsll3* / O60911* / P06797* / P07711* / Q80UB0* / Q9JI81...ENSDARG0000007430646
si:dkey-239j18.2 / Ctsr* / Ctsq* / Ctsm* / CTSL* / Ctsj* / Cts8* / Cts7* / Cts3* / Cts6* / CTSV* / Q9JI81* / Q9R014* / Ctsll3* / O60911* / P06797* / P07711* / Q80UB0* / Q91ZF2* / Q9JIA9* / ...ENSDARG0000009525446
ctslb / cathepsin Lb / Ctsr* / Ctsq* / Ctsm* / CTSL* / Ctsj* / Cts8* / Cts6* / Cts7* / CTSV* / Cts3* / Q91ZF2* / Q9R014* / Q9JIA9* / Ctsll3* / O60911* / P06797* / P07711* / Q80UB0* / Q9JI81...ENSDARG0000003917346
si:dkey-26g8.4 / Ctsr* / Ctsq* / Ctsm* / CTSL* / Ctsj* / Cts8* / Cts7* / Cts3* / Cts6* / CTSV* / Q9JI81* / Q9R014* / Ctsll3* / O60911* / P06797* / P07711* / Q80UB0* / Q91ZF2* / Q9JIA9* / BC...ENSDARG0000008765146
si:dkey-269i1.4 / Ctsr* / Ctsq* / Ctsm* / CTSL* / Ctsj* / Cts8* / Cts7* / Cts3* / Cts6* / CTSV* / Q9JI81* / Q9R014* / Ctsll3* / O60911* / P06797* / P07711* / Q80UB0* / Q91ZF2* / Q9JIA9* / B...ENSDARG0000009574446
zgc:174855 / Cts8* / Cts3* / Cts6* / Cts7* / Ctsj* / CTSL* / Ctsm* / Ctsq* / Ctsr* / CTSV* / Q9JIA9* / O60911* / Ctsll3* / Q9R014* / P06797* / P07711* / Q80UB0* / Q91ZF2* / Q9JI81* / BC0516...ENSDARG0000009455946
MGC174155 / Cathepsin L1-like / Ctsr* / Ctsq* / Ctsm* / CTSL* / Ctsj* / Cts8* / Cts6* / Cts7* / Cts3* / CTSV* / Q91ZF2* / Q9R014* / Q9JIA9* / Ctsll3* / O60911* / P06797* / P07711* / Q80UB0*...ENSDARG0000009507246
si:dkey-239j18.3 / Ctsr* / Ctsq* / Ctsm* / CTSL* / Ctsj* / Cts8* / Cts7* / Cts3* / Cts6* / CTSV* / Q9JI81* / Q9R014* / Ctsll3* / O60911* / P06797* / P07711* / Q80UB0* / Q91ZF2* / Q9JIA9* / ...ENSDARG0000008980646
si:dkey-269i1.4 / CTSL* / CTSV* / O60911* / P07711* / cathepsin V* / cathepsin L*ENSDARG0000010083346
zgc:174154 / Cts8* / Cts3* / Cts6* / Cts7* / Ctsj* / CTSL* / Ctsm* / Ctsq* / Ctsr* / CTSV* / Q9JIA9* / O60911* / Ctsll3* / Q9R014* / P06797* / P07711* / Q80UB0* / Q91ZF2* / Q9JI81* / BC0516...ENSDARG0000007552746
si:dkey-26g8.5 / Ctsr* / Ctsq* / Ctsm* / CTSL* / Ctsj* / Cts8* / Cts7* / Cts3* / Cts6* / CTSV* / Q9JI81* / Q9R014* / Ctsll3* / O60911* / P06797* / P07711* / Q80UB0* / Q91ZF2* / Q9JIA9* / BC...ENSDARG0000008975046
zgc:174153 / Cts8* / Cts3* / Cts6* / Cts7* / Ctsj* / CTSL* / Ctsm* / Ctsq* / Ctsr* / CTSV* / Q9JIA9* / O60911* / Ctsll3* / Q9R014* / P06797* / P07711* / Q80UB0* / Q91ZF2* / Q9JI81* / BC0516...ENSDARG0000007937646
ctsl.1 / cathepsin L.1ENSDARG0000000390245
cts12 / cathepsin 12ENSDARG0000004275345
ctsh / cathepsin H / P09668* / P49935*ENSDARG0000004110837


Protein motifs (from Interpro)
Interpro ID Name
 IPR000169  Cysteine peptidase, cysteine active site
 IPR000668  Peptidase C1A, papain C-terminal
 IPR013128  Peptidase C1A
 IPR013201  Cathepsin propeptide inhibitor domain (I29)
 IPR025660  Cysteine peptidase, histidine active site
 IPR025661  Cysteine peptidase, asparagine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0019882 antigen processing and presentation IBA
 biological_processGO:0034769 basement membrane disassembly IBA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IBA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005764 lysosome IBA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IBA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000009087 cd74a / CD74 molecule, major histocompatibility complex, class II invariant chain a / CD74* / P04233* / P04441* / CD74 molecule* / CD74 antigen (invariant polypeptide of major histocompatib...  / reaction






 

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