Manteia

ENSDARG00000056909

Danio rerio

Features

Gene ID:	ENSDARG00000056909

Biological name :	LO018309.1

Synonyms :	LO018309.1

Possible biological names infered from orthology :	erb-b2 receptor tyrosine kinase 4 / ERBB4 / Q15303 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain

Species:	Danio rerio

Chr. number:	24
Strand:	-1
Band:
Gene start:	33552198
Gene end:	33578392

Corresponding Affymetrix probe sets:

Cross references:	Ensembl peptide - ENSDARP00000073932 swissprot - E7FG42 Ensembl - ENSDARG00000056909

See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ERBB4	ENSGALG00000003126	Gallus gallus
ERBB4	ENSG00000178568	Homo sapiens
Erbb4	ENSMUSG00000062209	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
egfra / epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) / ERBB4* / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyr...	ENSDARG00000013847	54
erbb2 / erb-b2 receptor tyrosine kinase 2 / P04626* / P70424* / Receptor tyrosine-protein kinase erbB-2 *	ENSDARG00000026294	46
si:ch73-383l1.1	ENSDARG00000090408	45
erbb4b / erb-b2 receptor tyrosine kinase 4b	ENSDARG00000089536	44
erbb4a / erb-b2 receptor tyrosine kinase 4a	ENSDARG00000063207	43
erbb3b / erb-b2 receptor tyrosine kinase 3b / ERBB3* / P21860* / Q61526* / erb-b2 receptor tyrosine kinase 3* / Receptor tyrosine-protein kinase erbB-3 *	ENSDARG00000036993	41
erbb3a / erb-b2 receptor tyrosine kinase 3a / ERBB3* / P21860* / Q61526* / erb-b2 receptor tyrosine kinase 3* / Receptor tyrosine-protein kinase erbB-3 *	ENSDARG00000006202	40
ptk2ab / protein tyrosine kinase 2ab / PTK2* / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*	ENSDARG00000004672	9
ptk2bb / protein tyrosine kinase 2 beta, b / PTK2B* / Q14289* / Q9QVP9* / protein tyrosine kinase 2 beta* / PTK2 protein tyrosine kinase 2 beta*	ENSDARG00000039577	8
zap70 / zeta chain of T cell receptor associated protein kinase 70 / P43403* / P43404* / zeta-chain (TCR) associated protein kinase*	ENSDARG00000015752	8
syk / spleen tyrosine kinase / P43405* / P48025* / spleen associated tyrosine kinase*	ENSDARG00000008186	8
ptk2aa / protein tyrosine kinase 2aa / PTK2* / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*	ENSDARG00000100456	7
ptk2ba / protein tyrosine kinase 2 beta, a / PTK2B* / Q14289* / Q9QVP9* / protein tyrosine kinase 2 beta* / PTK2 protein tyrosine kinase 2 beta*	ENSDARG00000022841	7
tnk2a / tyrosine kinase, non-receptor, 2a / TNK2* / Q07912* / tyrosine kinase non receptor 2*	ENSDARG00000090646	5
tnk2b / tyrosine kinase, non-receptor, 2b / TNK2* / Q07912* / tyrosine kinase non receptor 2*	ENSDARG00000104409	4
tnk1 / tyrosine kinase, non-receptor, 1 / Q13470* / Q99ML2* / Non-receptor tyrosine-protein kinase TNK1 *	ENSDARG00000069433	3

Protein motifs (from Interpro)

Interpro ID	Name
IPR000494	Receptor L-domain
IPR006211	Furin-like cysteine-rich domain
IPR006212	Furin-like repeat
IPR009030	Growth factor receptor cysteine-rich domain superfamily
IPR032675	Leucine-rich repeat domain superfamily
IPR032778	Growth factor receptor domain 4

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006468	protein phosphorylation	IEA
biological_process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IEA
biological_process	GO:0018108	peptidyl-tyrosine phosphorylation	IEA
cellular_component	GO:0016020	membrane	IEA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0004713	protein tyrosine kinase activity	IEA
molecular_function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IEA
molecular_function	GO:0005524	ATP binding	IEA

Pathways (from Reactome)

Pathway description

Signaling by ERBB2

Signaling by ERBB4

SHC1 events in ERBB2 signaling

PI3K events in ERBB4 signaling

SHC1 events in ERBB4 signaling

Nuclear signaling by ERBB4

Downregulation of ERBB4 signaling

PIP3 activates AKT signaling

GRB2 events in ERBB2 signaling

PI3K events in ERBB2 signaling

RAF/MAP kinase cascade

ERBB2 Regulates Cell Motility

PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

ERBB2 Activates PTK6 Signaling

Downregulation of ERBB2 signaling

Estrogen-dependent gene expression

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr