Manteia

ENSDARG00000013847

Danio rerio

Features

Gene ID:	ENSDARG00000013847

Biological name :	egfra

Synonyms :	egfra / epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)

Possible biological names infered from orthology :	erb-b2 receptor tyrosine kinase 4 / ERBB4 / Q15303 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain

Species:	Danio rerio

Chr. number:	2
Strand:	1
Band:
Gene start:	3696038
Gene end:	3820159

Corresponding Affymetrix probe sets:

Cross references:	Ensembl peptide - ENSDARP00000125265 Ensembl peptide - ENSDARP00000104998 Ensembl peptide - ENSDARP00000113854 Ensembl peptide - ENSDARP00000121251 Ensembl peptide - ENSDARP00000099170 Ensembl peptide - ENSDARP00000132819 NCBI entrez gene - 378478 See in Manteia. RefSeq - NM_194424 RefSeq Peptide - NP_919405 swissprot - F1Q7X2 swissprot - A0A0R4IFV9 swissprot - F1QU74 swissprot - F1R671 swissprot - F1RA48 swissprot - F1RBY7 ZFIN ID - ZDB-GENE-030918-1 Ensembl - ENSDARG00000013847

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ERBB4	ENSGALG00000003126	Gallus gallus
ERBB4	ENSG00000178568	Homo sapiens
Erbb4	ENSMUSG00000062209	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
LO018309.1 / ERBB4* / Q15303* / erb-b2 receptor tyrosine kinase 4*	ENSDARG00000056909	54
erbb2 / erb-b2 receptor tyrosine kinase 2 / P04626* / P70424* / Receptor tyrosine-protein kinase erbB-2 *	ENSDARG00000026294	48
si:ch73-383l1.1	ENSDARG00000090408	46
erbb4b / erb-b2 receptor tyrosine kinase 4b	ENSDARG00000089536	45
erbb4a / erb-b2 receptor tyrosine kinase 4a	ENSDARG00000063207	45
erbb3b / erb-b2 receptor tyrosine kinase 3b / ERBB3* / P21860* / Q61526* / erb-b2 receptor tyrosine kinase 3* / Receptor tyrosine-protein kinase erbB-3 *	ENSDARG00000036993	43
erbb3a / erb-b2 receptor tyrosine kinase 3a / ERBB3* / P21860* / Q61526* / erb-b2 receptor tyrosine kinase 3* / Receptor tyrosine-protein kinase erbB-3 *	ENSDARG00000006202	40
ptk2ab / protein tyrosine kinase 2ab / PTK2* / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*	ENSDARG00000004672	9
ptk2bb / protein tyrosine kinase 2 beta, b / PTK2B* / Q14289* / Q9QVP9* / protein tyrosine kinase 2 beta* / PTK2 protein tyrosine kinase 2 beta*	ENSDARG00000039577	8
ptk2aa / protein tyrosine kinase 2aa / PTK2* / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*	ENSDARG00000100456	8
ptk2ba / protein tyrosine kinase 2 beta, a / PTK2B* / Q14289* / Q9QVP9* / protein tyrosine kinase 2 beta* / PTK2 protein tyrosine kinase 2 beta*	ENSDARG00000022841	8
syk / spleen tyrosine kinase / P43405* / P48025* / spleen associated tyrosine kinase*	ENSDARG00000008186	7
zap70 / zeta chain of T cell receptor associated protein kinase 70 / P43403* / P43404* / zeta-chain (TCR) associated protein kinase*	ENSDARG00000015752	7
tnk2b / tyrosine kinase, non-receptor, 2b / TNK2* / Q07912* / tyrosine kinase non receptor 2*	ENSDARG00000104409	4
tnk2a / tyrosine kinase, non-receptor, 2a / TNK2* / Q07912* / tyrosine kinase non receptor 2*	ENSDARG00000090646	4
tnk1 / tyrosine kinase, non-receptor, 1 / Q13470* / Q99ML2* / Non-receptor tyrosine-protein kinase TNK1 *	ENSDARG00000069433	2

Protein motifs (from Interpro)

Interpro ID	Name
IPR000494	Receptor L-domain
IPR000719	Protein kinase domain
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
IPR006211	Furin-like cysteine-rich domain
IPR006212	Furin-like repeat
IPR008266	Tyrosine-protein kinase, active site
IPR009030	Growth factor receptor cysteine-rich domain superfamily
IPR011009	Protein kinase-like domain superfamily
IPR016245	Tyrosine protein kinase, EGF/ERB/XmrK receptor
IPR017441	Protein kinase, ATP binding site
IPR020635	Tyrosine-protein kinase, catalytic domain
IPR032675	Leucine-rich repeat domain superfamily
IPR032778	Growth factor receptor domain 4

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006468	protein phosphorylation	IEA
biological_process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IEA
biological_process	GO:0016310	phosphorylation	IEA
biological_process	GO:0018108	peptidyl-tyrosine phosphorylation	IEA
biological_process	GO:0023014	signal transduction by protein phosphorylation	IEA
biological_process	GO:0035556	intracellular signal transduction	IEA
biological_process	GO:0072554	blood vessel lumenization	IMP
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0004713	protein tyrosine kinase activity	IEA
molecular_function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IEA
molecular_function	GO:0004716	obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity	IEA
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016301	kinase activity	IEA
molecular_function	GO:0016740	transferase activity	IEA

Pathways (from Reactome)

Pathway description

Signaling by ERBB2

Signaling by ERBB4

SHC1 events in ERBB2 signaling

PI3K events in ERBB4 signaling

SHC1 events in ERBB4 signaling

Nuclear signaling by ERBB4

Downregulation of ERBB4 signaling

PIP3 activates AKT signaling

GRB2 events in ERBB2 signaling

PI3K events in ERBB2 signaling

RAF/MAP kinase cascade

ERBB2 Regulates Cell Motility

PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

ERBB2 Activates PTK6 Signaling

Downregulation of ERBB2 signaling

Estrogen-dependent gene expression

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
ZFA:0000014	dorsal aorta	dorsal aorta decreased diameter , abnormal dorsal aorta blood vessel lumenization decreased process quality , abnormal	Show

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr