Manteia - Molecule gene

ENSMUSG00000004637

Mus musculus

Features

Gene ID:	ENSMUSG00000004637

Biological name :	Wwox

Synonyms :	Q91WL8 / WW domain-containing oxidoreductase / Wwox

Possible biological names infered from orthology :	Q9NZC7

Species:	Mus musculus

Chr. number:	8
Strand:	1
Band:	E1
Gene start:	114439655
Gene end:	115352708

Corresponding Affymetrix probe sets:	10575706 (MoGene1.0st) 1416334_at (Mouse Genome 430 2.0 Array) 1431942_at (Mouse Genome 430 2.0 Array) 1431960_at (Mouse Genome 430 2.0 Array) 1438517_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000004756 Ensembl peptide - ENSMUSP00000104735 Ensembl peptide - ENSMUSP00000104736 Ensembl peptide - ENSMUSP00000125626 NCBI entrez gene - 80707 See in Manteia. MGI - MGI:1931237 RefSeq - XM_011248558 RefSeq - NM_019573 RefSeq - XM_011248556 RefSeq - XM_011248557 RefSeq - XM_006531510 RefSeq - XM_006531511 RefSeq - XM_006531512 RefSeq - XM_006531513 RefSeq - XM_006531514 RefSeq Peptide - NP_062519 swissprot - Q91WL8 Ensembl - ENSMUSG00000004637

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
wwox	ENSDARG00000007614	Danio rerio
WWOX	ENSGALG00000005377	Gallus gallus
WWOX	ENSG00000186153	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Rdh12 / Q8BYK4 / Retinol dehydrogenase 12 / Q96NR8* / retinol dehydrogenase 12 (all-trans/9-cis/11-cis)*	ENSMUSG00000021123	31
Rdh14 / Q9ERI6 / Retinol dehydrogenase 14 / Q9HBH5*	ENSMUSG00000020621	29
Rdh13 / Q8CEE7 / Retinol dehydrogenase 13 / Q8NBN7*	ENSMUSG00000008435	29
Dhrs13 / Q5SS80 / Dehydrogenase/reductase SDR family member 13 / Q6UX07* / dehydrogenase/reductase 13*	ENSMUSG00000020834	28
Rdh11 / Q9QYF1 / Retinol dehydrogenase 11 / Q8TC12* / retinol dehydrogenase 11 (all-trans/9-cis/11-cis)*	ENSMUSG00000066441	28

Protein motifs (from Interpro)

Interpro ID	Name
IPR001202	WW domain
IPR002347	Short-chain dehydrogenase/reductase SDR
IPR036020	WW domain superfamily
IPR036291	NAD(P)-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001649	osteoblast differentiation	IMP
biological_process	GO:0006366	transcription by RNA polymerase II	IEA
biological_process	GO:0006915	apoptotic process	IEA
biological_process	GO:0016055	Wnt signaling pathway	IEA
biological_process	GO:0030178	negative regulation of Wnt signaling pathway	ISS
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA
biological_process	GO:0048705	skeletal system morphogenesis	IMP
biological_process	GO:0055114	oxidation-reduction process	IEA
biological_process	GO:0071560	cellular response to transforming growth factor beta stimulus	IDA
biological_process	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	IGI
biological_process	GO:0097191	extrinsic apoptotic signaling pathway	IDA
biological_process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	IMP
biological_process	GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005737	cytoplasm	ISS
cellular_component	GO:0005739	mitochondrion	IDA
cellular_component	GO:0005794	Golgi apparatus	ISO
cellular_component	GO:0005829	cytosol	ISO
cellular_component	GO:0005886	plasma membrane	ISO
cellular_component	GO:0005902	microvillus	ISO
cellular_component	GO:0090575	RNA polymerase II transcription factor complex	IDA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0016491	oxidoreductase activity	IBA
molecular_function	GO:0019899	enzyme binding	IPI

Pathways (from Reactome)

Pathway description

Nuclear signaling by ERBB4

Negative regulation of activity of TFAP2 (AP-2) family transcription factors

Activation of the TFAP2 (AP-2) family of transcription factors

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ Allelic Composition: Wwox^tm1.1Mald/Wwox^tm1.1Mald Genetic Background: involves: C57BL/6 * FVB/N Allelic Composition: Wwox^tm2.1Ria/Wwox^tm2.1Ria Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
MP:0000130	abnormal cancellous bone morphology	"structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ Allelic Composition: Wwox^tm2.1Ria/Wwox^tm2.1Ria Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
MP:0000135	reduced cortical bone thickness	"thinner than normal superficial layer of compact bone " [J:61509]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ Allelic Composition: Wwox^tm2.1Ria/Wwox^tm2.1Ria Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
MP:0000189	hypoglycemia	"low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ Allelic Composition: Wwox^tm2.1Ria/Wwox^tm2.1Ria Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
MP:0000195	hypocalcemia	"subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ Allelic Composition: Wwox^tm1.1Mald/Wwox^tm1.1Mald Genetic Background: involves: C57BL/6 * FVB/N
MP:0000221	decreased WBC count	"fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Wwox^tm1.1Mald/Wwox^tm1.1Mald Genetic Background: involves: C57BL/6 * FVB/N
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6
MP:0000692	small spleen	"decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Wwox^tm1.1Mald/Wwox^tm1.1Mald Genetic Background: involves: C57BL/6 * FVB/N
MP:0001127	small ovary	"reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0001147	small testis	"reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0001152	Leydig cell hyperplasia	"increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]	Show Allelic Composition: Wwox^Gt(XG218)Byg/Wwox^Gt(XG218)Byg Genetic Background: involves: 129P2/OlaHsd
MP:0001153	small seminiferous tubules	"reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0001154	seminiferous tubule degeneration	"a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]	Show Allelic Composition: Wwox^Gt(XG218)Byg/Wwox^Gt(XG218)Byg Genetic Background: involves: 129P2/OlaHsd
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Sox18^Ragl/Sox18^Ragl Genetic Background: involves: 129P3/J * C57BL/6J Allelic Composition: Wwox^tm2.1Ria/Wwox^tm2.1Ria Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0001541	abnormal osteoclast function	"reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0001566	hyperphosphatemia	"abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0001570	abnormal circulating enzyme level	"aberrent concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Wwox^tm1.1Mald/Wwox^tm1.1Mald Genetic Background: involves: C57BL/6 * FVB/N
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ Allelic Composition: Wwox^tm1.1Mald/Wwox^tm1.1Mald Genetic Background: involves: C57BL/6 * FVB/N Allelic Composition: Wwox^tm2.1Ria/Wwox^tm2.1Ria Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
MP:0001764	abnormal homeostasis	"anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0001922	reduced male fertility	"reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]	Show Allelic Composition: Wwox^Gt(XG218)Byg/Wwox^Gt(XG218)Byg Genetic Background: involves: 129P2/OlaHsd
MP:0001940	testicular hypoplasia	"decreased cell number in the testicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0002018	malignant tumors	"higher than normal incidence of locally invasive, destructive and metastatic tumors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:44427]	Show Allelic Composition: Wwox^Gt(XG218)Byg/Wwox^Gt(XG218)Byg Genetic Background: involves: 129P2/OlaHsd
MP:0002020	increased tumor incidence	"greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6
MP:0002023	B cell derived lymphoma	"heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Wwox^Gt(XG218)Byg/Wwox^Gt(XG218)Byg Genetic Background: involves: 129P2/OlaHsd
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 Allelic Composition: Wwox^Gt(XG218)Byg/Wwox^Gt(XG218)Byg Genetic Background: involves: 129P2/OlaHsd
MP:0002113	abnormal skeleton development	"anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0002176	high brain weight	"greater than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ Allelic Composition: Wwox^tm1.1Mald/Wwox^tm1.1Mald Genetic Background: involves: C57BL/6 * FVB/N
MP:0002371	abnormal thymus cortex morphology	"anomalous structure or development of the outer area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Wwox^tm1.1Mald/Wwox^tm1.1Mald Genetic Background: involves: C57BL/6 * FVB/N
MP:0002644	decreased circulating triglyceride level	"lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0002780	decreased circulating testosterone level	"less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0002966	decreased circulating alkaline phosphatase level	"reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0003017	decreased circulating bicarbonate level	"reduced concentration of inorganic salts that contain the -HCO3 radical in the circulation, which are an important factor in regulating the pH of the blood " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Wwox^tm1.1Mald/Wwox^tm1.1Mald Genetic Background: involves: C57BL/6 * FVB/N
MP:0003019	increased circulating chloride level	"elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Wwox^tm1.1Mald/Wwox^tm1.1Mald Genetic Background: involves: C57BL/6 * FVB/N
MP:0003020	decreased circulating chloride level	"reduced concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0003205	testicular atrophy	"wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]	Show Allelic Composition: Wwox^Gt(XG218)Byg/Wwox^Gt(XG218)Byg Genetic Background: involves: 129P2/OlaHsd
MP:0003402	decreased liver weight	"reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Wwox^tm1.1Mald/Wwox^tm1.1Mald Genetic Background: involves: C57BL/6 * FVB/N
MP:0003643	spleen atrophy	"wasting of the spleen resulting in reduced size" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Wwox^tm1.1Mald/Wwox^tm1.1Mald Genetic Background: involves: C57BL/6 * FVB/N
MP:0003789	osteosarcoma	"malignant neoplasm derived from bone" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6
MP:0003797	abnormal compact bone morphology	"structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Wwox^tm2.1Ria/Wwox^tm2.1Ria Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
MP:0004499	increased incidence of chemically-induced tumors	"higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6
MP:0004953	decreased spleen weight	"reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wwox^tm1.1Mald/Wwox^tm1.1Mald Genetic Background: involves: C57BL/6 * FVB/N
MP:0004956	decreased thymus weight	"reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wwox^tm1.1Mald/Wwox^tm1.1Mald Genetic Background: involves: C57BL/6 * FVB/N
MP:0004989	decreased osteoblast cell number	"reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wwox^tm1.1Mald/Wwox^tm1.1Mald Genetic Background: involves: C57BL/6 * FVB/N
MP:0004992	increased bone resorption	"greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0005150	cachexia	"general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ Allelic Composition: Wwox^tm1.1Mald/Wwox^tm1.1Mald Genetic Background: involves: C57BL/6 * FVB/N
MP:0005179	decreased total circulating cholesterol level	"less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0005344	increased circulating bilirubin level	"greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0005419	hypoalbuminemia	"blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0005508	abnormal skeleton morphology	"malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0005536	Leydig cell hypoplasia	"reduced numbers of the interstitial cells of the seminiferous tubules that secrete testosterone" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Wwox^tm1.1Mald/Wwox^tm1.1Mald Genetic Background: involves: C57BL/6 * FVB/N
MP:0005565	increased blood urea nitrogen level	"high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Wwox^tm1.1Mald/Wwox^tm1.1Mald Genetic Background: involves: C57BL/6 * FVB/N
MP:0005567	decreased circulating total protein level	"less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0005627	increased circulating potassium level	"greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0005632	decreased circulating aspartate transaminase level	"less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0005634	decreased circulating sodium level	"less than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0005646	abnormal pituitary gland physiology	"anmalous function of this unpaired compound gland suspended from the base of the hypothalamus by a short extension of the infundibulum, the infundibular or pituitary stalk" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0008014	lung tumor	"presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6
MP:0008395	abnormal osteoblast differentiation	"atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0008770	decreased survivor rate	"a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wwox^Gt(XG218)Byg/Wwox^Gt(XG218)Byg Genetic Background: involves: 129P2/OlaHsd
MP:0008821	increased blood uric acid level	"greater concentration in the blood of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MESH:D03.132.960.877, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0008939	increased pituitary gland weight	"greater than average weight of the compound gland suspended from the base of the hypothalamus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0009088	thin uterine horn	"reduced thickness of either one of the pair of tubular extensions from the uterine body where the uterus and the uterine tubes meet" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0009346	decreased cancellous bone thickness	"thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wwox^tm1.1Mald/Wwox^tm1.1Mald Genetic Background: involves: C57BL/6 * FVB/N
MP:0009362	abnormal primary ovarian follicle morphology	"any structural abnormality in the ovarian follicle prior to the appearance of an antrum, normally marked by developmental changes in the primary oocyte and follicular cells so that the latter form one or more layers of cuboidal or columnar cells; the follicle becomes surrounded by a sheath of stroma, the theca" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0009370	decreased thecal cell number	"fewer than normal numbers of cells in the sheath of stroma surrounding a secondary ovarian follicle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ
MP:0010280	increased skeletal tumor incidence	"greater than the expected number of neoplasms in the skeletal tissue, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wwox^tm2.1Ria/Wwox^tm2.1Ria Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
MP:0010869	decreased bone trabecula number	"decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wwox^tm1.1Mald/Wwox^tm1.1Mald Genetic Background: involves: C57BL/6 * FVB/N Allelic Composition: Wwox^tm2.1Ria/Wwox^tm2.1Ria Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
MP:0010879	decreased trabecular bone volume	"decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wwox^tm1.1Mald/Wwox^tm1.1Mald Genetic Background: involves: C57BL/6 * FVB/N Allelic Composition: Wwox^tm2.1Ria/Wwox^tm2.1Ria Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
MP:0010933	decreased trabecular bone connectivity density	"reduction in the extent of attachments between trabeculae; it may be expressed in ratios of nodes to free ends, trabecular bone pattern factor, and related measures" [ISBN:0120986523 "Principles of bone biology, Volume 1, Bilezikian, JP et al, eds"]	Show Allelic Composition: Wwox^tm2.1Ria/Wwox^tm2.1Ria Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
MP:0010968	decreased compact bone area	"reduction in the total amount of cross-sectional area of compact bone tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wwox^tm2.1Ria/Wwox^tm2.1Ria Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ Allelic Composition: Wwox^tm1.1Mald/Wwox^tm1.1Mald Genetic Background: involves: C57BL/6 * FVB/N Allelic Composition: Wwox^tm2.1Ria/Wwox^tm2.1Ria Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
MP:0013307	increased adrenal gland weight	"greater average weight of the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla " [MGI:Anna]	Show Allelic Composition: Gusb^mps/Gusb^mps,Kit^W-41J/Kit^W-41J Genetic Background: B6(C)-Kit^W-41J Gusb^mps/BrkJ

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000028640	Q61312 / Tfap2c / transcription factor AP-2, gamma / Q92754*	/ reaction / complex
ENSMUSG00000062209	Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*	/ reaction / complex

1 s.

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