ENSMUSG00000066441


Mus musculus

Features
Gene ID: ENSMUSG00000066441
  
Biological name :Rdh11
  
Synonyms : Q9QYF1 / Rdh11 / Retinol dehydrogenase 11
  
Possible biological names infered from orthology : Q8TC12 / retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: C3
Gene start: 79174337
Gene end: 79192293
  
Corresponding Affymetrix probe sets: 10401181 (MoGene1.0st)   1418760_at (Mouse Genome 430 2.0 Array)   1449209_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124066
Ensembl peptide - ENSMUSP00000082352
Ensembl peptide - ENSMUSP00000123829
NCBI entrez gene - 17252     See in Manteia.
MGI - MGI:102581
RefSeq - NM_021557
RefSeq Peptide - NP_067532
swissprot - E0CYX0
swissprot - Q9QYF1
swissprot - Q9R1R8
Ensembl - ENSMUSG00000066441
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rdh12ENSDARG00000018069Danio rerio
 ENSGALG00000009538Gallus gallus
 RDH11ENSG00000072042Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rdh12 / Q8BYK4 / Retinol dehydrogenase 12 / Q96NR8* / retinol dehydrogenase 12 (all-trans/9-cis/11-cis)*ENSMUSG0000002112367
Rdh13 / Q8CEE7 / Retinol dehydrogenase 13 / Q8NBN7*ENSMUSG0000000843549
Rdh14 / Q9ERI6 / Retinol dehydrogenase 14 / Q9HBH5*ENSMUSG0000002062144
Dhrs13 / Q5SS80 / Dehydrogenase/reductase SDR family member 13 / Q6UX07* / dehydrogenase/reductase 13*ENSMUSG0000002083443
Wwox / Q91WL8 / WW domain-containing oxidoreductase / Q9NZC7*ENSMUSG0000000463736


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016062 adaptation of rhodopsin mediated signaling IMP
 biological_processGO:0042572 retinol metabolic process IEA
 biological_processGO:0042574 retinal metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0001917 photoreceptor inner segment IDA
 cellular_componentGO:0005622 intracellular ISS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004745 retinol dehydrogenase activity ISS
 molecular_functionGO:0016491 oxidoreductase activity IBA
 molecular_functionGO:0052650 NADP-retinol dehydrogenase activity ISO


Pathways (from Reactome)
Pathway description
The canonical retinoid cycle in rods (twilight vision)
RA biosynthesis pathway
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003011 delayed dark adaptation "increase in time required for the eye to recover its sensitivity in the dark following exposure to bright lights" [J:68444, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Rdh11tm1Tsyk/Rdh11tm1Tsyk,Rdh5tm1Drie/Rdh5tm1Drie
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Rdh11tm1Akjc/Rdh11tm1Akjc
Genetic Background: Not Specified

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039194 Rlbp1 / Q9Z275 / retinaldehyde binding protein 1 / P12271*  / reaction
 ENSMUSG00000032454 Rbp2 / Q08652 / retinol binding protein 2, cellular / P50120* / retinol binding protein 2*  / reaction






 

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