ENSG00000002746


Homo sapiens

Features
Gene ID: ENSG00000002746
  
Biological name :HECW1
  
Synonyms : HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 / HECW1 / Q76N89
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: p14.1
Gene start: 43112599
Gene end: 43566001
  
Corresponding Affymetrix probe sets: 210331_at (Human Genome U133 Plus 2.0 Array)   215584_at (Human Genome U133 Plus 2.0 Array)   243163_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000379228
Ensembl peptide - ENSP00000407774
Ensembl peptide - ENSP00000413336
NCBI entrez gene - 23072     See in Manteia.
OMIM - 610384
RefSeq - XM_017011890
RefSeq - NM_001287059
RefSeq - NM_015052
RefSeq - XM_017011886
RefSeq - XM_017011887
RefSeq - XM_017011888
RefSeq - XM_017011889
RefSeq - XM_005249665
RefSeq - XM_006715670
RefSeq - XM_006715671
RefSeq - XM_006715673
RefSeq - XM_011515220
RefSeq - XM_011515222
RefSeq - XM_011515223
RefSeq - XM_011515224
RefSeq - XM_011515225
RefSeq - XM_011515226
RefSeq - XM_017011882
RefSeq - XM_017011883
RefSeq - XM_017011884
RefSeq - XM_017011885
RefSeq Peptide - NP_001273988
RefSeq Peptide - NP_055867
swissprot - Q76N89
swissprot - H7C3Q2
Ensembl - ENSG00000002746
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hecw1bENSDARG00000004291Danio rerio
 si:ch211-188f17.1ENSDARG00000100958Danio rerio
 HECW1ENSGALG00000037193Gallus gallus
 Hecw1ENSMUSG00000021301Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HECW2 / Q9P2P5 / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2ENSG0000013841157
NEDD4 / P46934 / neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligaseENSG0000006986920
NEDD4L / Q96PU5 / neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligaseENSG0000004975920
ITCH / Q96J02 / itchy E3 ubiquitin protein ligaseENSG0000007874719
WWP1 / Q9H0M0 / WW domain containing E3 ubiquitin protein ligase 1ENSG0000012312419
WWP2 / O00308 / WW domain containing E3 ubiquitin protein ligase 2ENSG0000019837318
Q9HCE7 / SMURF1 / SMAD specific E3 ubiquitin protein ligase 1ENSG0000019874217
Q9HAU4 / SMURF2 / SMAD specific E3 ubiquitin protein ligase 2ENSG0000010885417
HACE1 / Q8IYU2 / HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1ENSG0000008538214


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000569  HECT domain
 IPR001202  WW domain
 IPR032348  E3 ubiquitin-protein ligase HECW1/2, N-terminal
 IPR035892  C2 domain superfamily
 IPR035983  HECT, E3 ligase catalytic domain
 IPR036020  WW domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity TAS


Pathways (from Reactome)
Pathway description
Degradation of DVL


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000107404 DVL1 / O14640 / dishevelled segment polarity protein 1  / complex / reaction






 

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