ENSG00000198373


Homo sapiens

Features
Gene ID: ENSG00000198373
  
Biological name :WWP2
  
Synonyms : O00308 / WW domain containing E3 ubiquitin protein ligase 2 / WWP2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: q22.1
Gene start: 69762306
Gene end: 69941741
  
Corresponding Affymetrix probe sets: 1552737_s_at (Human Genome U133 Plus 2.0 Array)   1554580_a_at (Human Genome U133 Plus 2.0 Array)   204022_at (Human Genome U133 Plus 2.0 Array)   210200_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000456451
Ensembl peptide - ENSP00000456216
Ensembl peptide - ENSP00000456582
Ensembl peptide - ENSP00000348283
Ensembl peptide - ENSP00000352069
Ensembl peptide - ENSP00000455311
Ensembl peptide - ENSP00000455347
NCBI entrez gene - 11060     See in Manteia.
OMIM - 602308
RefSeq - XM_017022881
RefSeq - NM_001270453
RefSeq - NM_001270454
RefSeq - NM_001270455
RefSeq - NM_007014
RefSeq - NM_199424
RefSeq - XM_011522823
RefSeq - XM_011522825
RefSeq - XM_011522826
RefSeq - XM_017022879
RefSeq - XM_017022880
RefSeq Peptide - NP_001257383
RefSeq Peptide - NP_001257384
RefSeq Peptide - NP_008945
RefSeq Peptide - NP_955456
RefSeq Peptide - NP_001257382
swissprot - H3BPJ8
swissprot - H3BRX8
swissprot - H3BS79
swissprot - O00308
swissprot - A0A024R711
Ensembl - ENSG00000198373
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wwp2ENSDARG00000061345Danio rerio
 WWP2ENSGALG00000000699Gallus gallus
 Wwp2ENSMUSG00000031930Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
WWP1 / Q9H0M0 / WW domain containing E3 ubiquitin protein ligase 1ENSG0000012312463
ITCH / Q96J02 / itchy E3 ubiquitin protein ligaseENSG0000007874757
NEDD4L / Q96PU5 / neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligaseENSG0000004975936
NEDD4 / P46934 / neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligaseENSG0000006986934
Q9HAU4 / SMURF2 / SMAD specific E3 ubiquitin protein ligase 2ENSG0000010885434
HECW1 / Q76N89 / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1ENSG0000000274633
HECW2 / Q9P2P5 / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2ENSG0000013841132
Q9HCE7 / SMURF1 / SMAD specific E3 ubiquitin protein ligase 1ENSG0000019874231
HACE1 / Q8IYU2 / HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1ENSG0000008538224


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000569  HECT domain
 IPR001202  WW domain
 IPR024928  E3 ubiquitin-protein ligase, SMURF1 type
 IPR035892  C2 domain superfamily
 IPR035983  HECT, E3 ligase catalytic domain
 IPR036020  WW domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006464 cellular protein modification process TAS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006858 extracellular transport IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016567 protein ubiquitination IMP
 biological_processGO:0032410 negative regulation of transporter activity IDA
 biological_processGO:0034765 regulation of ion transmembrane transport IDA
 biological_processGO:0042391 regulation of membrane potential IDA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity ISS
 biological_processGO:0045746 negative regulation of Notch signaling pathway TAS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046718 viral entry into host cell TAS
 biological_processGO:0051224 negative regulation of protein transport IMP
 biological_processGO:0051865 protein autoubiquitination IDA
 biological_processGO:0070534 protein K63-linked ubiquitination ISS
 biological_processGO:1901016 regulation of potassium ion transmembrane transporter activity IDA
 cellular_componentGO:0000151 ubiquitin ligase complex TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding ISS
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity TAS


Pathways (from Reactome)
Pathway description
Regulation of PTEN stability and activity
NOTCH3 Activation and Transmission of Signal to the Nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000074181 NOTCH3 / Q9UM47  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr