ENSGALG00000000699


Gallus gallus

Features
Gene ID: ENSGALG00000000699
  
Biological name :WWP2
  
Synonyms : NEDD4-like E3 ubiquitin-protein ligase WWP2 / WWP2
  
Possible biological names infered from orthology : O00308 / Q9DBH0 / WW domain containing E3 ubiquitin protein ligase 2
  
Species: Gallus gallus
  
Chr. number: 11
Strand: 1
Band:
Gene start: 19283823
Gene end: 19315488
  
Corresponding Affymetrix probe sets: Gga.16253.1.S1_at (Chicken Array)   GgaAffx.26762.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000000989
Ensembl peptide - ENSGALP00000049801
Ensembl peptide - ENSGALP00000049054
NCBI entrez gene - 415868     See in Manteia.
RefSeq - XM_015292597
RefSeq - XM_015292592
RefSeq - XM_015292593
RefSeq - XM_015292594
RefSeq - XM_015292596
RefSeq - NM_001039260
RefSeq - XM_015292591
RefSeq Peptide - NP_001034349
swissprot - E1C3L4
swissprot - A0A1D5PAN8
swissprot - A0A1D5P8K6
Ensembl - ENSGALG00000000699
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wwp2ENSDARG00000061345Danio rerio
 WWP2ENSG00000198373Homo sapiens
 Wwp2ENSMUSG00000031930Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
WWP1 / WW domain containing E3 ubiquitin protein ligase 1 / Q8BZZ3* / Q9H0M0*ENSGALG0000004179559
ITCH / itchy E3 ubiquitin protein ligase / Q8C863* / Q96J02* / E3 ubiquitin-protein ligase Itchy *ENSGALG0000004047454
NEDD4L* / Q96PU5* / neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase*ENSGALG0000003458435
NEDD4L* / Q96PU5* / neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase*ENSGALG0000003135534
NEDD4 / neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase / P46934* / P46935* / neural precursor cell expressed, developmentally down-regulated 4*ENSGALG0000000434732
HECW2 / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 / Q6I6G8* / Q9P2P5* / E3 ubiquitin-protein ligase HECW2 *ENSGALG0000000794431
SMURF2 / SMAD specific E3 ubiquitin protein ligase 2 / A2A5Z6* / Q9HAU4* / E3 ubiquitin-protein ligase SMURF2 *ENSGALG0000000356631
HECW1 / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 / Q76N89* / Q8K4P8* / E3 ubiquitin-protein ligase HECW1 *ENSGALG0000003719331
SMURF1 / SMAD specific E3 ubiquitin protein ligase 1 / Q9CUN6* / Q9HCE7* / E3 ubiquitin-protein ligase SMURF1 *ENSGALG0000000465530
HACE1 / E1C656 / E3 ubiquitin-protein ligase HACE1 / Q3U0D9* / Q8IYU2* / HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1*ENSGALG0000001541522


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000569  HECT domain
 IPR001202  WW domain
 IPR024928  E3 ubiquitin-protein ligase, SMURF1 type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006858 extracellular transport IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0032410 negative regulation of transporter activity IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0042391 regulation of membrane potential IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051224 negative regulation of protein transport IEA
 biological_processGO:0051865 protein autoubiquitination IEA
 biological_processGO:0070534 protein K63-linked ubiquitination IEA
 biological_processGO:1901016 regulation of potassium ion transmembrane transporter activity IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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