ENSMUSG00000005610


Mus musculus

Features
Gene ID: ENSMUSG00000005610
  
Biological name :Eif4g2
  
Synonyms : Eif4g2 / eukaryotic translation initiation factor 4 gamma 2 isoform 2
  
Possible biological names infered from orthology : eukaryotic translation initiation factor 4 gamma 2 / P78344
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E3
Gene start: 111067750
Gene end: 111083030
  
Corresponding Affymetrix probe sets: 10566966 (MoGene1.0st)   1415863_at (Mouse Genome 430 2.0 Array)   1428362_at (Mouse Genome 430 2.0 Array)   1428363_at (Mouse Genome 430 2.0 Array)   1452758_s_at (Mouse Genome 430 2.0 Array)   1458431_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124914
Ensembl peptide - ENSMUSP00000123811
Ensembl peptide - ENSMUSP00000124551
Ensembl peptide - ENSMUSP00000125375
Ensembl peptide - ENSMUSP00000125098
Ensembl peptide - ENSMUSP00000125301
NCBI entrez gene - 13690     See in Manteia.
MGI - MGI:109207
RefSeq - NM_013507
RefSeq - NM_001040131
RefSeq Peptide - NP_038535
RefSeq Peptide - NP_001035221
swissprot - G3XA17
swissprot - F7CHS2
swissprot - F7CBP1
swissprot - F6UU81
swissprot - F6TW20
swissprot - F7DAB1
Ensembl - ENSMUSG00000005610
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif4g2aENSDARG00000020377Danio rerio
 eif4g2bENSDARG00000057167Danio rerio
 EIF4G2ENSGALG00000005587Gallus gallus
 EIF4G2ENSG00000110321Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eif4g1 / Q6NZJ6 / Eukaryotic translation initiation factor 4 gamma 1 / Q04637*ENSMUSG0000004598328
Eif4g3 / Mus musculus eukaryotic translation initiation factor 4 gamma, 3 (Eif4g3), transcript variant 4, mRNA. / O43432* / eukaryotic translation initiation factor 4 gamma 3*ENSMUSG0000002876026


Protein motifs (from Interpro)
Interpro ID Name
 IPR003307  W2 domain
 IPR003890  MIF4G-like, type 3
 IPR003891  Initiation factor eIF-4 gamma, MA3
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006413 translational initiation IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0045773 positive regulation of axon extension IEA
 biological_processGO:0060999 positive regulation of dendritic spine development IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0030424 axon IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003743 translation initiation factor activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Ehmt1tm1b(EUCOMM)Hmgu/Ehmt1+
Genetic Background: C57BL/6N-Ehmt1tm1b(EUCOMM)Hmgu/Nju

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Ehmt1tm1b(EUCOMM)Hmgu/Ehmt1+
Genetic Background: C57BL/6N-Ehmt1tm1b(EUCOMM)Hmgu/Nju

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Ehmt1tm1b(EUCOMM)Hmgu/Ehmt1+
Genetic Background: C57BL/6N-Ehmt1tm1b(EUCOMM)Hmgu/Nju

 MP:0001674 abnormal triploblastic development "abnormal development of the three primary germ layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnq1tm1Kpfe/Kcnq1tm1Kpfe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
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Allelic Composition: Kcnq1tm1Kpfe/Kcnq1tm1Kpfe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
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Allelic Composition: Kcnq1tm1Kpfe/Kcnq1tm1Kpfe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ehmt1tm1b(EUCOMM)Hmgu/Ehmt1+
Genetic Background: C57BL/6N-Ehmt1tm1b(EUCOMM)Hmgu/Nju

 MP:0003020 decreased circulating chloride level "reduced concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Ehmt1tm1b(EUCOMM)Hmgu/Ehmt1+
Genetic Background: C57BL/6N-Ehmt1tm1b(EUCOMM)Hmgu/Nju

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Ehmt1tm1b(EUCOMM)Hmgu/Ehmt1+
Genetic Background: C57BL/6N-Ehmt1tm1b(EUCOMM)Hmgu/Nju

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnq1tm1Kpfe/Kcnq1tm1Kpfe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kcnq1tm1Kpfe/Kcnq1tm1Kpfe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Ehmt1tm1b(EUCOMM)Hmgu/Ehmt1+
Genetic Background: C57BL/6N-Ehmt1tm1b(EUCOMM)Hmgu/Nju

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Kcnq1tm1Kpfe/Kcnq1tm1Kpfe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Ehmt1tm1b(EUCOMM)Hmgu/Ehmt1+
Genetic Background: C57BL/6N-Ehmt1tm1b(EUCOMM)Hmgu/Nju

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Ehmt1tm1b(EUCOMM)Hmgu/Ehmt1+
Genetic Background: C57BL/6N-Ehmt1tm1b(EUCOMM)Hmgu/Nju

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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