ENSG00000177479


Homo sapiens

Features
Gene ID: ENSG00000177479
  
Biological name :ARIH2
  
Synonyms : ariadne RBR E3 ubiquitin protein ligase 2 / ARIH2 / O95376
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p21.31
Gene start: 48918821
Gene end: 48986382
  
Corresponding Affymetrix probe sets: 201228_s_at (Human Genome U133 Plus 2.0 Array)   201229_s_at (Human Genome U133 Plus 2.0 Array)   201230_s_at (Human Genome U133 Plus 2.0 Array)   216008_s_at (Human Genome U133 Plus 2.0 Array)   227932_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000399788
Ensembl peptide - ENSP00000397225
Ensembl peptide - ENSP00000403222
Ensembl peptide - ENSP00000406063
Ensembl peptide - ENSP00000404838
Ensembl peptide - ENSP00000403845
Ensembl peptide - ENSP00000348769
Ensembl peptide - ENSP00000395560
NCBI entrez gene - 10425     See in Manteia.
OMIM - 605615
RefSeq - XM_017005541
RefSeq - XM_011533271
RefSeq - XM_011533273
RefSeq - XM_011533275
RefSeq - XM_017005531
RefSeq - XM_017005532
RefSeq - XM_017005533
RefSeq - XM_017005534
RefSeq - XM_017005535
RefSeq - XM_017005536
RefSeq - XM_017005537
RefSeq - XM_017005538
RefSeq - XM_017005539
RefSeq - XM_017005540
RefSeq - NM_001317333
RefSeq - NM_001317334
RefSeq - NM_006321
RefSeq - XM_011533265
RefSeq - XM_011533266
RefSeq - XM_011533267
RefSeq - XM_011533268
RefSeq - XM_011533270
RefSeq Peptide - NP_001304262
RefSeq Peptide - NP_001304263
RefSeq Peptide - NP_001336138
RefSeq Peptide - NP_001336139
RefSeq Peptide - NP_001336140
RefSeq Peptide - NP_006312
swissprot - C9JZ71
swissprot - C9JAU2
swissprot - C9JCL4
swissprot - C9JBC5
swissprot - F8WCS4
swissprot - O95376
swissprot - Q6IBL8
Ensembl - ENSG00000177479
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arih2ENSDARG00000012848Danio rerio
 ARIH2ENSGALG00000006956Gallus gallus
 Arih2ENSMUSG00000064145Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ARIH1 / Q9Y4X5 / ariadne RBR E3 ubiquitin protein ligase 1ENSG0000016623333
ANKIB1 / Q9P2G1 / ankyrin repeat and IBR domain containing 1ENSG0000000162929


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR002867  IBR domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR031126  E3 ubiquitin-protein ligase ARIH2
 IPR031127  E3 ubiquitin ligase RBR family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IDA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0048588 developmental cell growth IDA
 biological_processGO:0070534 protein K63-linked ubiquitination IDA
 biological_processGO:0070936 protein K48-linked ubiquitination IDA
 biological_processGO:0071425 hematopoietic stem cell proliferation IDA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0031466 Cul5-RING ubiquitin ligase complex IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031624 ubiquitin conjugating enzyme binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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