ENSMUSG00000064145


Mus musculus

Features
Gene ID: ENSMUSG00000064145
  
Biological name :Arih2
  
Synonyms : Arih2 / Mus musculus ariadne RBR E3 ubiquitin protein ligase 2 (Arih2), transcript variant 2, mRNA. / Q9Z1K6
  
Possible biological names infered from orthology : ariadne RBR E3 ubiquitin protein ligase 2 / O95376
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F2
Gene start: 108602942
Gene end: 108649386
  
Corresponding Affymetrix probe sets: 10386400 (MoGene1.0st)   10596951 (MoGene1.0st)   1418523_at (Mouse Genome 430 2.0 Array)   1445934_at (Mouse Genome 430 2.0 Array)   1449119_at (Mouse Genome 430 2.0 Array)   1454802_x_at (Mouse Genome 430 2.0 Array)   1455013_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000013338
Ensembl peptide - ENSMUSP00000142102
Ensembl peptide - ENSMUSP00000141914
Ensembl peptide - ENSMUSP00000141911
Ensembl peptide - ENSMUSP00000141369
Ensembl peptide - ENSMUSP00000141364
NCBI entrez gene - 23807     See in Manteia.
MGI - MGI:1344361
RefSeq - XM_006511728
RefSeq - NM_001357283
RefSeq - NM_001357285
RefSeq - NM_011790
RefSeq - XM_006511725
RefSeq Peptide - NP_001344214
RefSeq Peptide - NP_035920
RefSeq Peptide - NP_001344212
swissprot - A0A0A6YXA7
swissprot - A0A0A6YW29
swissprot - A0A0A6YW24
swissprot - Q3TK92
swissprot - A0A0A6YXB0
swissprot - Q9Z1K6
swissprot - A0A0A6YXR5
Ensembl - ENSMUSG00000064145
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arih2ENSDARG00000012848Danio rerio
 ARIH2ENSGALG00000006956Gallus gallus
 ARIH2ENSG00000177479Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arih1 / Q9Z1K5 / E3 ubiquitin-protein ligase ARIH1 / Q9Y4X5* / ariadne RBR E3 ubiquitin protein ligase 1*ENSMUSG0000002523434
Ankib1 / Q6ZPS6 / Ankyrin repeat and IBR domain-containing protein 1 / Q9P2G1* / ankyrin repeat and IBR domain containing 1*ENSMUSG0000004035130


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR002867  IBR domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR031126  E3 ubiquitin-protein ligase ARIH2
 IPR031127  E3 ubiquitin ligase RBR family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0048588 developmental cell growth ISO
 biological_processGO:0070534 protein K63-linked ubiquitination IEA
 biological_processGO:0070936 protein K48-linked ubiquitination IEA
 biological_processGO:0071425 hematopoietic stem cell proliferation IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IBA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0031466 Cul5-RING ubiquitin ligase complex ISS
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031624 ubiquitin conjugating enzyme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
Show

Allelic Composition: Krt71Ca-15J/Krt71Ca-15J
Genetic Background: involves: C57BL/6J

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Krt71Ca-15J/Krt71Ca-15J
Genetic Background: involves: C57BL/6J

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

Allelic Composition: Arih2tm1.1(KOMP)Vlcg/Arih2+
Genetic Background: C57BL/6N-Arih2tm1.1(KOMP)Vlcg/Ucd

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
Show

Allelic Composition: Krt71Ca-15J/Krt71Ca-15J
Genetic Background: involves: C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Krt71Ca-15J/Krt71Ca-15J
Genetic Background: involves: C57BL/6J

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

Allelic Composition: Arih2tm1.1(KOMP)Vlcg/Arih2+
Genetic Background: C57BL/6N-Arih2tm1.1(KOMP)Vlcg/Ucd

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Krt71Ca-15J/Krt71Ca-15J
Genetic Background: involves: C57BL/6J

Allelic Composition: Arih2tm1Mak/Arih2tm1Mak
Genetic Background: B6.129P2-Arih2tm1Mak

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Krt71Ca-15J/Krt71Ca-15J
Genetic Background: involves: C57BL/6J

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Krt71Ca-15J/Krt71Ca-15J
Genetic Background: involves: C57BL/6J

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Krt71Ca-15J/Krt71Ca-15J
Genetic Background: involves: C57BL/6J

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Arih2tm1Mak/Arih2tm1Mak
Genetic Background: B6.129P2-Arih2tm1Mak

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

Allelic Composition: Arih2tm1.1(KOMP)Vlcg/Arih2+
Genetic Background: C57BL/6N-Arih2tm1.1(KOMP)Vlcg/Ucd

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
Show

Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

Allelic Composition: Arih2tm1.1(KOMP)Vlcg/Arih2+
Genetic Background: C57BL/6N-Arih2tm1.1(KOMP)Vlcg/Ucd

 MP:0003864 abnormal midbrain development "anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

Allelic Composition: Arih2tm1.1(KOMP)Vlcg/Arih2+
Genetic Background: C57BL/6N-Arih2tm1.1(KOMP)Vlcg/Ucd

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Krt71Ca-15J/Krt71Ca-15J
Genetic Background: involves: C57BL/6J

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Arih2tm1Mak/Arih2tm1Mak
Genetic Background: B6.129P2-Arih2tm1Mak

 MP:0006108 abnormal hindbrain development "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]
Show

Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

Allelic Composition: Arih2tm1.1(KOMP)Vlcg/Arih2+
Genetic Background: C57BL/6N-Arih2tm1.1(KOMP)Vlcg/Ucd

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arih2tm1Mak/Arih2tm1Mak
Genetic Background: B6.129P2-Arih2tm1Mak

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Krt71Ca-15J/Krt71Ca-15J
Genetic Background: involves: C57BL/6J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Arih2tm1Mak/Arih2tm1Mak
Genetic Background: B6.129P2-Arih2tm1Mak

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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