ENSMUSG00000025580


Mus musculus

Features
Gene ID: ENSMUSG00000025580
  
Biological name :Eif4a3
  
Synonyms : Eif4a3 / Eukaryotic initiation factor 4A-III Eukaryotic initiation factor 4A-III, N-terminally processed / Q91VC3
  
Possible biological names infered from orthology : eukaryotic translation initiation factor 4A3 / P38919
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 119288363
Gene end: 119300089
  
Corresponding Affymetrix probe sets: 10393642 (MoGene1.0st)   10539177 (MoGene1.0st)   10541067 (MoGene1.0st)   1417242_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101860
Ensembl peptide - ENSMUSP00000026667
NCBI entrez gene - 192170     See in Manteia.
MGI - MGI:1923731
RefSeq - NM_138669
RefSeq Peptide - NP_619610
swissprot - A2AFK7
swissprot - Q91VC3
Ensembl - ENSMUSG00000025580
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif4a3ENSDARG00000102978Danio rerio
 EIF4A3ENSGALG00000008530Gallus gallus
 EIF4A3ENSG00000141543Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm5580 / EIF4A3* / P38919* / eukaryotic translation initiation factor 4A3*ENSMUSG0000010790697
Gm8994 / EIF4A3* / P38919* / eukaryotic translation initiation factor 4A3*ENSMUSG0000009497396
Eif4a2 / P10630 / Mus musculus eukaryotic translation initiation factor 4A2 (Eif4a2), transcript variant 5, mRNA.ENSMUSG0000002288466
Eif4a1 / P60843 / Eukaryotic initiation factor 4A-I / P60842* / eukaryotic translation initiation factor 4A1*ENSMUSG0000005979666


Protein motifs (from Interpro)
Interpro ID Name
 IPR000629  ATP-dependent RNA helicase DEAD-box, conserved site
 IPR001650  Helicase, C-terminal
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014014  RNA helicase, DEAD-box type, Q motif
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
 biological_processGO:0000381 regulation of alternative mRNA splicing, via spliceosome ISS
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0010501 RNA secondary structure unwinding IBA
 biological_processGO:0017148 negative regulation of translation ISO
 biological_processGO:0045727 positive regulation of translation ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048026 positive regulation of mRNA splicing, via spliceosome IMP
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis ISS
 biological_processGO:0051028 mRNA transport IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0035145 exon-exon junction complex ISO
 cellular_componentGO:0071013 catalytic step 2 spliceosome IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding ISO
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity ISO
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008143 poly(A) binding ISO
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Cleavage of Growing Transcript in the Termination Region
ISG15 antiviral mechanism
Transport of Mature mRNA derived from an Intron-Containing Transcript
Deadenylation of mRNA
mRNA Splicing - Major Pathway
mRNA 3-end processing
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000078676 Casc3 / Q8K3W3 / Protein CASC3 / O15234* / cancer susceptibility 3*  / complex
 ENSMUSG00000035692 Isg15 / Q64339 / Ubiquitin-like protein ISG15 / P05161* / ISG15 ubiquitin-like modifier*  / reaction
 ENSMUSG00000026254 Eif4e2 / Q8BMB3 / Mus musculus eukaryotic translation initiation factor 4E member 2 (Eif4e2), transcript variant 4, mRNA. / O60573* / eukaryotic translation initiation factor 4E family member 2*  / reaction
 ENSMUSG00000027078 Q9QZU9 / Ube2l6 / ubiquitin-conjugating enzyme E2L 6 / O14933*  / reaction
 ENSMUSG00000034681 Rnps1 / Q99M28 / RNA-binding protein with serine-rich domain 1 / Q15287*  / complex
 ENSMUSG00000025234 Arih1 / Q9Z1K5 / E3 ubiquitin-protein ligase ARIH1 / Q9Y4X5* / ariadne RBR E3 ubiquitin protein ligase 1*  / reaction
 ENSMUSG00000028609 Magoh / P61327 / Protein mago nashi homolog / P61326* / mago homolog, exon junction complex core component*  / complex
 ENSMUSG00000038398 Upf3a / UPF3 regulator of nonsense transcripts homolog A (yeast) / Q9H1J1* / UPF3A, regulator of nonsense mediated mRNA decay*  / complex
 ENSMUSG00000093661 Eif4e3 / Q9DBB5 / Eukaryotic translation initiation factor 4E type 3 / Q8N5X7* / eukaryotic translation initiation factor 4E family member 3*  / complex
 ENSMUSG00000043241 Upf2 / UPF2 regulator of nonsense transcripts homolog (yeast) / Q9HAU5* / UPF2, regulator of nonsense mediated mRNA decay*  / complex
 ENSMUSG00000038374 Rbm8a / Q9CWZ3 / RNA-binding protein 8A / Q9Y5S9* / RNA binding motif protein 8A*  / complex
 ENSMUSG00000045983 Eif4g1 / Q6NZJ6 / Eukaryotic translation initiation factor 4 gamma 1 / Q04637*  / complex
 ENSMUSG00000036572 Upf3b / UPF3 regulator of nonsense transcripts homolog B (yeast) / Q9BZI7* / UPF3B, regulator of nonsense mediated mRNA decay*  / complex






 

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