ENSMUSG00000078676


Mus musculus

Features
Gene ID: ENSMUSG00000078676
  
Biological name :Casc3
  
Synonyms : Casc3 / Protein CASC3 / Q8K3W3
  
Possible biological names infered from orthology : cancer susceptibility 3 / O15234
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 98804905
Gene end: 98833814
  
Corresponding Affymetrix probe sets: 10381032 (MoGene1.0st)   1416736_at (Mouse Genome 430 2.0 Array)   1441274_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000017384
Ensembl peptide - ENSMUSP00000130926
NCBI entrez gene - 192160     See in Manteia.
MGI - MGI:2179723
RefSeq - NM_138660
RefSeq Peptide - NP_619601
swissprot - Q8K3W3
Ensembl - ENSMUSG00000078676
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 casc3ENSDARG00000029911Danio rerio
 CASC3ENSGALG00000031813Gallus gallus
 CASC3ENSG00000108349Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR018545  Btz domain
 IPR028544  Protein CASC3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0008298 intracellular mRNA localization IDA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0051028 mRNA transport IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0010494 cytoplasmic stress granule IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031965 nuclear membrane ISO
 cellular_componentGO:0035145 exon-exon junction complex ISO
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
Cleavage of Growing Transcript in the Termination Region
Transport of Mature mRNA derived from an Intron-Containing Transcript
mRNA 3-end processing
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Smarcd2tm1.1(KOMP)Vlcg/Smarcd2+
Genetic Background: C57BL/6N-Smarcd2tm1.1(KOMP)Vlcg/Ucd

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smarcd2tm1.1(KOMP)Vlcg/Smarcd2+
Genetic Background: C57BL/6N-Smarcd2tm1.1(KOMP)Vlcg/Ucd

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smarcd2tm1.1(KOMP)Vlcg/Smarcd2+
Genetic Background: C57BL/6N-Smarcd2tm1.1(KOMP)Vlcg/Ucd

Allelic Composition: Casc3Gt(RRU345)Byg/Casc3tm1(KOMP)Vlcg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smarcd2tm1.1(KOMP)Vlcg/Smarcd2+
Genetic Background: C57BL/6N-Smarcd2tm1.1(KOMP)Vlcg/Ucd

Allelic Composition: Casc3Gt(RRU345)Byg/Casc3tm1(KOMP)Vlcg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Smarcd2tm1.1(KOMP)Vlcg/Smarcd2+
Genetic Background: C57BL/6N-Smarcd2tm1.1(KOMP)Vlcg/Ucd

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Smarcd2tm1.1(KOMP)Vlcg/Smarcd2+
Genetic Background: C57BL/6N-Smarcd2tm1.1(KOMP)Vlcg/Ucd

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Cacna1stm1.1(KOMP)Vlcg/Cacna1stm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cacna1stm1.1(KOMP)Vlcg/J

 MP:0012531 delayed limb development "late onset of the induction and/or differentiation of the limbs" [MGI:anna]
Show

Allelic Composition: Smarcd2tm1.1(KOMP)Vlcg/Smarcd2+
Genetic Background: C57BL/6N-Smarcd2tm1.1(KOMP)Vlcg/Ucd

Allelic Composition: Casc3Gt(RRU345)Byg/Casc3tm1(KOMP)Vlcg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac

 MP:0014134 abnormal embryo morphology "any structural anomaly of an embryo " [MGI:csmith]
Show

Allelic Composition: Smarcd2tm1.1(KOMP)Vlcg/Smarcd2+
Genetic Background: C57BL/6N-Smarcd2tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000094973 Gm8994 / EIF4A3* / P38919* / eukaryotic translation initiation factor 4A3*  / complex
 ENSMUSG00000025580 Eif4a3 / Q91VC3 / Eukaryotic initiation factor 4A-III Eukaryotic initiation factor 4A-III, N-terminally processed / P38919* / eukaryotic translation initiation factor 4A3*  / complex
 ENSMUSG00000034681 Rnps1 / Q99M28 / RNA-binding protein with serine-rich domain 1 / Q15287*  / complex
 ENSMUSG00000038374 Rbm8a / Q9CWZ3 / RNA-binding protein 8A / Q9Y5S9* / RNA binding motif protein 8A*  / complex
 ENSMUSG00000028609 Magoh / P61327 / Protein mago nashi homolog / P61326* / mago homolog, exon junction complex core component*  / complex
 ENSMUSG00000038398 Upf3a / UPF3 regulator of nonsense transcripts homolog A (yeast) / Q9H1J1* / UPF3A, regulator of nonsense mediated mRNA decay*  / complex
 ENSMUSG00000043241 Upf2 / UPF2 regulator of nonsense transcripts homolog (yeast) / Q9HAU5* / UPF2, regulator of nonsense mediated mRNA decay*  / complex
 ENSMUSG00000036572 Upf3b / UPF3 regulator of nonsense transcripts homolog B (yeast) / Q9BZI7* / UPF3B, regulator of nonsense mediated mRNA decay*  / complex






 

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