ENSMUSG00000036572


Mus musculus

Features
Gene ID: ENSMUSG00000036572
  
Biological name :Upf3b
  
Synonyms : Upf3b / UPF3 regulator of nonsense transcripts homolog B (yeast)
  
Possible biological names infered from orthology : Q9BZI7 / UPF3B, regulator of nonsense mediated mRNA decay
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A3.3
Gene start: 37091678
Gene end: 37110322
  
Corresponding Affymetrix probe sets: 10604078 (MoGene1.0st)   1434842_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000075614
Ensembl peptide - ENSMUSP00000121631
NCBI entrez gene - 68134     See in Manteia.
MGI - MGI:1915384
RefSeq - NM_026573
RefSeq - XM_006541394
RefSeq Peptide - NP_080849
swissprot - F6Q8N5
swissprot - Q3ULL6
Ensembl - ENSMUSG00000036572
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 upf3bENSDARG00000000489Danio rerio
 UPF3BENSGALG00000008618Gallus gallus
 UPF3BENSG00000125351Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Upf3a / UPF3 regulator of nonsense transcripts homolog A (yeast) / Q9H1J1* / UPF3A, regulator of nonsense mediated mRNA decay*ENSMUSG0000003839838


Protein motifs (from Interpro)
Interpro ID Name
 IPR005120  UPF3 domain
 IPR034979  UPF3B, RNA recognition motif-like domain
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
 biological_processGO:0006986 response to unfolded protein ISO
 biological_processGO:0045727 positive regulation of translation ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005815 microtubule organizing center ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0035145 exon-exon junction complex ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003729 mRNA binding ISO


Pathways (from Reactome)
Pathway description
Cleavage of Growing Transcript in the Termination Region
Transport of Mature mRNA derived from an Intron-Containing Transcript
mRNA Splicing - Major Pathway
mRNA 3-end processing
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: 129S6/SvEvTac-Atmtm1Awb/J

Allelic Composition: Upf3bGt(IST14619B5)Tigm/Upf3bGt(IST14619B5)Tigm
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: 129S6/SvEvTac-Atmtm1Awb/J

Allelic Composition: Upf3bGt(IST14619B5)Tigm/Upf3bGt(IST14619B5)Tigm
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: 129S6/SvEvTac-Atmtm1Awb/J

Allelic Composition: Upf3bGt(IST14619B5)Tigm/Upf3bGt(IST14619B5)Tigm
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: 129S6/SvEvTac-Atmtm1Awb/J

Allelic Composition: Upf3bGt(IST14619B5)Tigm/Upf3bGt(IST14619B5)Tigm
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: 129S6/SvEvTac-Atmtm1Awb/J

Allelic Composition: Upf3bGt(IST14619B5)Tigm/Upf3bGt(IST14619B5)Tigm
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Upf3bGt(IST14619B5)Tigm/Upf3b+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: 129S6/SvEvTac-Atmtm1Awb/J

Allelic Composition: Upf3bGt(IST14619B5)Tigm/Upf3bGt(IST14619B5)Tigm
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Upf3bGt(IST14619B5)Tigm/Upf3b+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
Show

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: 129S6/SvEvTac-Atmtm1Awb/J

Allelic Composition: Upf3bGt(IST14619B5)Tigm/Upf3bGt(IST14619B5)Tigm
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0011827 impaired neuron differentiation "decreased production of or inability to produce the mature cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith]
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Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: 129S6/SvEvTac-Atmtm1Awb/J

Allelic Composition: Upf3bGt(IST14619B5)Tigm/Upf3bGt(IST14619B5)Tigm
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0012286 decreased frequency of paradoxical sleep "decreased incidence or duration of the sleep stage in which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity" [http://orcid.org/0000-0001-5208-3432]
Show

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: 129S6/SvEvTac-Atmtm1Awb/J

Allelic Composition: Upf3bGt(IST14619B5)Tigm/Upf3bGt(IST14619B5)Tigm
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0012292 decreased slow-wave sleep duration "reduced length of time of the third, or deep sleep stage of NREM sleep" [MGI:csmith]
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Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: 129S6/SvEvTac-Atmtm1Awb/J

Allelic Composition: Upf3bGt(IST14619B5)Tigm/Upf3bGt(IST14619B5)Tigm
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0020393 increased neuronal precursor proliferation "increase in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:anna]
Show

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: 129S6/SvEvTac-Atmtm1Awb/J

Allelic Composition: Upf3bGt(IST14619B5)Tigm/Upf3bGt(IST14619B5)Tigm
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0020508 decreased dendritic spine density "decrease in the number of dendritic spines in a given cross-sectional area of a dendrite" [MGI:smb]
Show

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: 129S6/SvEvTac-Atmtm1Awb/J

Allelic Composition: Upf3bGt(IST14619B5)Tigm/Upf3bGt(IST14619B5)Tigm
Genetic Background: involves: C57BL/6J * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000094973 Gm8994 / EIF4A3* / P38919* / eukaryotic translation initiation factor 4A3*  / complex
 ENSMUSG00000025580 Eif4a3 / Q91VC3 / Eukaryotic initiation factor 4A-III Eukaryotic initiation factor 4A-III, N-terminally processed / P38919* / eukaryotic translation initiation factor 4A3*  / complex
 ENSMUSG00000043241 Upf2 / UPF2 regulator of nonsense transcripts homolog (yeast) / Q9HAU5* / UPF2, regulator of nonsense mediated mRNA decay*  / complex
 ENSMUSG00000034681 Rnps1 / Q99M28 / RNA-binding protein with serine-rich domain 1 / Q15287*  / complex
 ENSMUSG00000038374 Rbm8a / Q9CWZ3 / RNA-binding protein 8A / Q9Y5S9* / RNA binding motif protein 8A*  / complex
 ENSMUSG00000078676 Casc3 / Q8K3W3 / Protein CASC3 / O15234* / cancer susceptibility 3*  / complex
 ENSMUSG00000028609 Magoh / P61327 / Protein mago nashi homolog / P61326* / mago homolog, exon junction complex core component*  / complex






 

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