ENSMUSG00000038398


Mus musculus

Features
Gene ID: ENSMUSG00000038398
  
Biological name :Upf3a
  
Synonyms : Upf3a / UPF3 regulator of nonsense transcripts homolog A (yeast)
  
Possible biological names infered from orthology : Q9H1J1 / UPF3A, regulator of nonsense mediated mRNA decay
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A1.1
Gene start: 13785615
Gene end: 13799193
  
Corresponding Affymetrix probe sets: 10570418 (MoGene1.0st)   1452971_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037354
NCBI entrez gene - 67031     See in Manteia.
MGI - MGI:1914281
RefSeq - NM_025924
RefSeq - XM_006508860
RefSeq Peptide - NP_080200
swissprot - Q3ULJ3
Ensembl - ENSMUSG00000038398
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 upf3aENSDARG00000069297Danio rerio
 UPF3AENSGALG00000016815Gallus gallus
 UPF3AENSG00000169062Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Upf3b / UPF3 regulator of nonsense transcripts homolog B (yeast) / Q9BZI7* / UPF3B, regulator of nonsense mediated mRNA decay*ENSMUSG0000003657243


Protein motifs (from Interpro)
Interpro ID Name
 IPR005120  UPF3 domain
 IPR034978  Regulator of nonsense transcripts 3A
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
 biological_processGO:0006913 nucleocytoplasmic transport IEA
 biological_processGO:0006986 response to unfolded protein ISO
 biological_processGO:0045727 positive regulation of translation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0035145 exon-exon junction complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003729 mRNA binding ISO
 molecular_functionGO:0042162 telomeric DNA binding IEA


Pathways (from Reactome)
Pathway description
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Gt(ROSA)26Sortm12.1Sia/Gt(ROSA)26Sor+,Haus6tm1.2Sdwb/Haus6tm1.2Sdwb
Genetic Background: B6.Cg-Haus6tm1.2Sdwb Gt(ROSA)26Sortm12.1Sia

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm12.1Sia/Gt(ROSA)26Sor+,Haus6tm1.2Sdwb/Haus6tm1.2Sdwb
Genetic Background: B6.Cg-Haus6tm1.2Sdwb Gt(ROSA)26Sortm12.1Sia

Allelic Composition: Tg(Stra8-icre)1Reb/0,Upf3atm1.1Wilk/Upf3a+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm12.1Sia/Gt(ROSA)26Sor+,Haus6tm1.2Sdwb/Haus6tm1.2Sdwb
Genetic Background: B6.Cg-Haus6tm1.2Sdwb Gt(ROSA)26Sortm12.1Sia

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm12.1Sia/Gt(ROSA)26Sor+,Haus6tm1.2Sdwb/Haus6tm1.2Sdwb
Genetic Background: B6.Cg-Haus6tm1.2Sdwb Gt(ROSA)26Sortm12.1Sia

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0006205 embryonic lethality before somite formation "death anytime after implantation but before somite formation (E4.5 to less than E8)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm12.1Sia/Gt(ROSA)26Sor+,Haus6tm1.2Sdwb/Haus6tm1.2Sdwb
Genetic Background: B6.Cg-Haus6tm1.2Sdwb Gt(ROSA)26Sortm12.1Sia

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm12.1Sia/Gt(ROSA)26Sor+,Haus6tm1.2Sdwb/Haus6tm1.2Sdwb
Genetic Background: B6.Cg-Haus6tm1.2Sdwb Gt(ROSA)26Sortm12.1Sia

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm12.1Sia/Gt(ROSA)26Sor+,Haus6tm1.2Sdwb/Haus6tm1.2Sdwb
Genetic Background: B6.Cg-Haus6tm1.2Sdwb Gt(ROSA)26Sortm12.1Sia

Allelic Composition: Tg(Stra8-icre)1Reb/0,Upf3atm1.1Wilk/Upf3a+
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * FVB/NJ

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm12.1Sia/Gt(ROSA)26Sor+,Haus6tm1.2Sdwb/Haus6tm1.2Sdwb
Genetic Background: B6.Cg-Haus6tm1.2Sdwb Gt(ROSA)26Sortm12.1Sia

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm12.1Sia/Gt(ROSA)26Sor+,Haus6tm1.2Sdwb/Haus6tm1.2Sdwb
Genetic Background: B6.Cg-Haus6tm1.2Sdwb Gt(ROSA)26Sortm12.1Sia

 MP:0011610 abnormal primordial germ cell apoptosis "change in the timing or the number of primordial germ cells undergoing programmed cell death" [MGI:smb]
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Allelic Composition: Gt(ROSA)26Sortm12.1Sia/Gt(ROSA)26Sor+,Haus6tm1.2Sdwb/Haus6tm1.2Sdwb
Genetic Background: B6.Cg-Haus6tm1.2Sdwb Gt(ROSA)26Sortm12.1Sia

 MP:0014134 abnormal embryo morphology "any structural anomaly of an embryo " [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm12.1Sia/Gt(ROSA)26Sor+,Haus6tm1.2Sdwb/Haus6tm1.2Sdwb
Genetic Background: B6.Cg-Haus6tm1.2Sdwb Gt(ROSA)26Sortm12.1Sia

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038374 Rbm8a / Q9CWZ3 / RNA-binding protein 8A / Q9Y5S9* / RNA binding motif protein 8A*  / complex
 ENSMUSG00000028609 Magoh / P61327 / Protein mago nashi homolog / P61326* / mago homolog, exon junction complex core component*  / complex
 ENSMUSG00000078676 Casc3 / Q8K3W3 / Protein CASC3 / O15234* / cancer susceptibility 3*  / complex
 ENSMUSG00000043241 Upf2 / UPF2 regulator of nonsense transcripts homolog (yeast) / Q9HAU5* / UPF2, regulator of nonsense mediated mRNA decay*  / complex
 ENSMUSG00000034681 Rnps1 / Q99M28 / RNA-binding protein with serine-rich domain 1 / Q15287*  / complex
 ENSMUSG00000025580 Eif4a3 / Q91VC3 / Eukaryotic initiation factor 4A-III Eukaryotic initiation factor 4A-III, N-terminally processed / P38919* / eukaryotic translation initiation factor 4A3*  / complex
 ENSMUSG00000094973 Gm8994 / EIF4A3* / P38919* / eukaryotic translation initiation factor 4A3*  / complex






 

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