ENSG00000169062


Homo sapiens

Features
Gene ID: ENSG00000169062
  
Biological name :UPF3A
  
Synonyms : Q9H1J1 / UPF3A / UPF3A, regulator of nonsense mediated mRNA decay
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: 1
Band: q34
Gene start: 114281584
Gene end: 114305817
  
Corresponding Affymetrix probe sets: 206958_s_at (Human Genome U133 Plus 2.0 Array)   206959_s_at (Human Genome U133 Plus 2.0 Array)   214323_s_at (Human Genome U133 Plus 2.0 Array)   217596_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000482320
Ensembl peptide - ENSP00000329592
Ensembl peptide - ENSP00000364448
NCBI entrez gene - 65110     See in Manteia.
OMIM - 605530
RefSeq - XM_017020711
RefSeq - NM_001353646
RefSeq - NM_023011
RefSeq - NM_080687
RefSeq - XM_011534846
RefSeq - XM_011534847
RefSeq - XM_011534848
RefSeq - XM_017020709
RefSeq - XM_017020710
RefSeq - XM_005266202
RefSeq - XM_006719991
RefSeq - XM_011534844
RefSeq - XM_011534845
RefSeq Peptide - NP_001340575
RefSeq Peptide - NP_075387
RefSeq Peptide - NP_542418
swissprot - Q9H1J1
swissprot - A0A087WZ33
Ensembl - ENSG00000169062
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 upf3aENSDARG00000069297Danio rerio
 UPF3AENSGALG00000016815Gallus gallus
 Upf3aENSMUSG00000038398Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
UPF3B / Q9BZI7 / UPF3B, regulator of nonsense mediated mRNA decayENSG0000012535143


Protein motifs (from Interpro)
Interpro ID Name
 IPR005120  UPF3 domain
 IPR034978  Regulator of nonsense transcripts 3A
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
 biological_processGO:0006913 nucleocytoplasmic transport IEA
 biological_processGO:0045727 positive regulation of translation IDA
 biological_processGO:0051028 mRNA transport IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm NAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0035145 exon-exon junction complex TAS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017056 structural constituent of nuclear pore NAS
 molecular_functionGO:0042162 telomeric DNA binding IDA


Pathways (from Reactome)
Pathway description
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000141543 EIF4A3 / P38919 / eukaryotic translation initiation factor 4A3  / complex
 ENSG00000108349 CASC3 / O15234 / cancer susceptibility 3  / complex
 ENSG00000151461 UPF2 / Q9HAU5 / UPF2, regulator of nonsense mediated mRNA decay  / complex
 ENSG00000162385 MAGOH / P61326 / mago homolog, exon junction complex core component  / complex
 ENSG00000265241 RBM8A / Q9Y5S9 / RNA binding motif protein 8A  / complex
 ENSG00000111196 MAGOHB / Q96A72 / mago homolog B, exon junction complex core component  / complex
 ENSG00000205937 RNPS1 / Q15287 / RNA binding protein with serine rich domain 1  / complex






 

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