ENSG00000108349


Homo sapiens

Features
Gene ID: ENSG00000108349
  
Biological name :CASC3
  
Synonyms : cancer susceptibility 3 / CASC3 / O15234
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q21.1
Gene start: 40140318
Gene end: 40172183
  
Corresponding Affymetrix probe sets: 207842_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000264645
Ensembl peptide - ENSP00000462713
Ensembl peptide - ENSP00000464626
Ensembl peptide - ENSP00000467654
NCBI entrez gene - 22794     See in Manteia.
OMIM - 606504
RefSeq - XM_005257163
RefSeq - NM_007359
RefSeq Peptide - NP_031385
swissprot - K7EQ38
swissprot - J3KSY7
swissprot - O15234
swissprot - J3QSC4
Ensembl - ENSG00000108349
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 casc3ENSDARG00000029911Danio rerio
 CASC3ENSGALG00000031813Gallus gallus
 Casc3ENSMUSG00000078676Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR018545  Btz domain
 IPR028544  Protein CASC3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
 biological_processGO:0000398 mRNA splicing, via spliceosome TAS
 biological_processGO:0006369 termination of RNA polymerase II transcription TAS
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006405 RNA export from nucleus TAS
 biological_processGO:0006406 mRNA export from nucleus TAS
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0008150 biological_process ND
 biological_processGO:0008298 intracellular mRNA localization IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0031124 mRNA 3"-end processing TAS
 biological_processGO:0051028 mRNA transport IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0010494 cytoplasmic stress granule IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031965 nuclear membrane IDA
 cellular_componentGO:0035145 exon-exon junction complex IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042802 identical protein binding IDA


Pathways (from Reactome)
Pathway description
Cleavage of Growing Transcript in the Termination Region
Transport of Mature mRNA derived from an Intron-Containing Transcript
mRNA Splicing - Major Pathway
mRNA 3-end processing
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000162385 MAGOH / P61326 / mago homolog, exon junction complex core component  / complex
 ENSG00000111196 MAGOHB / Q96A72 / mago homolog B, exon junction complex core component  / complex
 ENSG00000205937 RNPS1 / Q15287 / RNA binding protein with serine rich domain 1  / complex
 ENSG00000265241 RBM8A / Q9Y5S9 / RNA binding motif protein 8A  / complex
 ENSG00000151461 UPF2 / Q9HAU5 / UPF2, regulator of nonsense mediated mRNA decay  / complex
 ENSG00000125351 UPF3B / Q9BZI7 / UPF3B, regulator of nonsense mediated mRNA decay  / complex
 ENSG00000141543 EIF4A3 / P38919 / eukaryotic translation initiation factor 4A3  / complex
 ENSG00000169062 UPF3A / Q9H1J1 / UPF3A, regulator of nonsense mediated mRNA decay  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr