ENSG00000162385


Homo sapiens

Features
Gene ID: ENSG00000162385
  
Biological name :MAGOH
  
Synonyms : MAGOH / mago homolog, exon junction complex core component / P61326
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p32.3
Gene start: 53226892
Gene end: 53238610
  
Corresponding Affymetrix probe sets: 210092_at (Human Genome U133 Plus 2.0 Array)   210093_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000360525
Ensembl peptide - ENSP00000360521
NCBI entrez gene - 4116     See in Manteia.
OMIM - 602603
RefSeq - NM_002370
RefSeq Peptide - NP_002361
swissprot - P61326
Ensembl - ENSG00000162385
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 magohENSDARG00000038635Danio rerio
 MagohENSMUSG00000028609Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAGOHB / Q96A72 / mago homolog B, exon junction complex core componentENSG0000011119698


Protein motifs (from Interpro)
Interpro ID Name
 IPR004023  Mago nashi protein
 IPR036605  Mago nashi superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IGI
 biological_processGO:0000381 regulation of alternative mRNA splicing, via spliceosome IMP
 biological_processGO:0000398 mRNA splicing, via spliceosome TAS
 biological_processGO:0006369 termination of RNA polymerase II transcription TAS
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006405 RNA export from nucleus TAS
 biological_processGO:0006406 mRNA export from nucleus TAS
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0031124 mRNA 3"-end processing TAS
 biological_processGO:0051028 mRNA transport IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0035145 exon-exon junction complex IDA
 cellular_componentGO:0071013 catalytic step 2 spliceosome IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Cleavage of Growing Transcript in the Termination Region
Transport of Mature mRNA derived from an Intron-Containing Transcript
mRNA Splicing - Major Pathway
mRNA 3-end processing
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108349 CASC3 / O15234 / cancer susceptibility 3  / complex
 ENSG00000125351 UPF3B / Q9BZI7 / UPF3B, regulator of nonsense mediated mRNA decay  / complex
 ENSG00000141543 EIF4A3 / P38919 / eukaryotic translation initiation factor 4A3  / complex
 ENSG00000169062 UPF3A / Q9H1J1 / UPF3A, regulator of nonsense mediated mRNA decay  / complex
 ENSG00000151461 UPF2 / Q9HAU5 / UPF2, regulator of nonsense mediated mRNA decay  / complex
 ENSG00000205937 RNPS1 / Q15287 / RNA binding protein with serine rich domain 1  / complex
 ENSG00000265241 RBM8A / Q9Y5S9 / RNA binding motif protein 8A  / complex






 

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