ENSMUSG00000028609


Mus musculus

Features
Gene ID: ENSMUSG00000028609
  
Biological name :Magoh
  
Synonyms : Magoh / P61327 / Protein mago nashi homolog
  
Possible biological names infered from orthology : mago homolog, exon junction complex core component / P61326
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C7
Gene start: 107879755
Gene end: 107887424
  
Corresponding Affymetrix probe sets: 10506736 (MoGene1.0st)   1416212_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030348
NCBI entrez gene - 17149     See in Manteia.
MGI - MGI:1330312
RefSeq - NM_001282737
RefSeq Peptide - NP_001269666
swissprot - P61327
Ensembl - ENSMUSG00000028609
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 magohENSDARG00000038635Danio rerio
 MAGOHENSG00000162385Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MagohbENSMUSG0000003018899


Protein motifs (from Interpro)
Interpro ID Name
 IPR004023  Mago nashi protein
 IPR036605  Mago nashi superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
 biological_processGO:0000381 regulation of alternative mRNA splicing, via spliceosome IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007292 female gamete generation NAS
 biological_processGO:0008380 RNA splicing IBA
 biological_processGO:0051028 mRNA transport IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0035145 exon-exon junction complex IEA
 cellular_componentGO:0071013 catalytic step 2 spliceosome IEA
 molecular_functionGO:0003723 RNA binding IEA


Pathways (from Reactome)
Pathway description
Cleavage of Growing Transcript in the Termination Region
Transport of Mature mRNA derived from an Intron-Containing Transcript
mRNA Splicing - Major Pathway
mRNA 3-end processing
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000373 belly spot "the appearance of a round area of white fur on the belly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Magohtm1c(KOMP)Dlsi/Magoh+,Emx1tm1(cre)Krj/Emx1+
Genetic Background: B6.Cg-Magohtm1c(KOMP)Dlsi Emx1tm1(cre)Krj

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

Allelic Composition: MagohGt(AG0150)Wtsi/Magoh+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: MagohGt(AT0027)Wtsi/Magoh+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Magohtm1c(KOMP)Dlsi/Magoh+,Emx1tm1(cre)Krj/Emx1+
Genetic Background: B6.Cg-Magohtm1c(KOMP)Dlsi Emx1tm1(cre)Krj

Allelic Composition: Magohtm1d(KOMP)Dlsi/Magoh+
Genetic Background: involves: C57BL/6J * FVB

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

Allelic Composition: MagohGt(AG0150)Wtsi/Magoh+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: MagohGt(AT0027)Wtsi/Magoh+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Abcc6tm1Jfk/Abcc6tm1Jfk,Samd9ltm1Homy/Samd9ltm1Homy
Genetic Background: B6.129-Samd9ltm1Homy Abcc6tm1Jfk

 MP:0003202 abnormal neuron apoptosis "change in the timing or the number of neurons undergoing programmed cell death" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0005408 hypopigmentation "dilution of the pigment in the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

Allelic Composition: MagohGt(AG0150)Wtsi/Magoh+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: MagohGt(AT0027)Wtsi/Magoh+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Magohtm1d(KOMP)Dlsi/Magoh+
Genetic Background: involves: C57BL/6J * FVB

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Abcc6tm1Jfk/Abcc6tm1Jfk,Samd9ltm1Homy/Samd9ltm1Homy
Genetic Background: B6.129-Samd9ltm1Homy Abcc6tm1Jfk

Allelic Composition: Magohtm1c(KOMP)Dlsi/Magoh+,Emx1tm1(cre)Krj/Emx1+
Genetic Background: B6.Cg-Magohtm1c(KOMP)Dlsi Emx1tm1(cre)Krj

Allelic Composition: Magohtm1d(KOMP)Dlsi/Magoh+
Genetic Background: involves: C57BL/6J * FVB

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

Allelic Composition: MagohGt(AG0150)Wtsi/Magoh+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: MagohGt(AT0027)Wtsi/Magoh+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0009760 abnormal mitotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
Show

Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0009967 abnormal neuron proliferation "any anomaly in the ability of a neuron to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

Allelic Composition: MagohGt(AG0150)Wtsi/Magoh+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: MagohGt(AT0027)Wtsi/Magoh+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ecel1tm1Hiki/Ecel1tm1Hiki
Genetic Background: B6.129-Ecel1tm1Hiki

 MP:0011724 ectopic cortical neuron "appearance of a cerebral cortical neuron or group of cerebral cortical neurons in a region where it is not normally found" [MGI:csmith]
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Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0012138 decreased forebrain size "size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
Show

Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0014178 increased brain apoptosis "increase in the number of cells of the brain undergoing programmed cell death" [MGI:Anna]
Show

Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0020069 decreased neocortex size "size reduction or truncation of the neocortex" [GOC:NV]
Show

Allelic Composition: Add2tm1Llp/Add2tm1Llp,Add3tm1.2Llp/Add3tm1.2Llp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000078676 Casc3 / Q8K3W3 / Protein CASC3 / O15234* / cancer susceptibility 3*  / complex
 ENSMUSG00000025580 Eif4a3 / Q91VC3 / Eukaryotic initiation factor 4A-III Eukaryotic initiation factor 4A-III, N-terminally processed / P38919* / eukaryotic translation initiation factor 4A3*  / complex
 ENSMUSG00000034681 Rnps1 / Q99M28 / RNA-binding protein with serine-rich domain 1 / Q15287*  / complex
 ENSMUSG00000038374 Rbm8a / Q9CWZ3 / RNA-binding protein 8A / Q9Y5S9* / RNA binding motif protein 8A*  / complex
 ENSMUSG00000094973 Gm8994 / EIF4A3* / P38919* / eukaryotic translation initiation factor 4A3*  / complex
 ENSMUSG00000038398 Upf3a / UPF3 regulator of nonsense transcripts homolog A (yeast) / Q9H1J1* / UPF3A, regulator of nonsense mediated mRNA decay*  / complex
 ENSMUSG00000043241 Upf2 / UPF2 regulator of nonsense transcripts homolog (yeast) / Q9HAU5* / UPF2, regulator of nonsense mediated mRNA decay*  / complex
 ENSMUSG00000036572 Upf3b / UPF3 regulator of nonsense transcripts homolog B (yeast) / Q9BZI7* / UPF3B, regulator of nonsense mediated mRNA decay*  / complex






 

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