ENSMUSG00000043241


Mus musculus

Features
Gene ID: ENSMUSG00000043241
  
Biological name :Upf2
  
Synonyms : Upf2 / UPF2 regulator of nonsense transcripts homolog (yeast)
  
Possible biological names infered from orthology : Q9HAU5 / UPF2, regulator of nonsense mediated mRNA decay
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A1
Gene start: 5951469
Gene end: 6056703
  
Corresponding Affymetrix probe sets: 10469083 (MoGene1.0st)   1435030_at (Mouse Genome 430 2.0 Array)   1445777_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119348
Ensembl peptide - ENSMUSP00000058375
NCBI entrez gene - 326622     See in Manteia.
MGI - MGI:2449307
RefSeq - XM_006497485
RefSeq - XM_006497487
RefSeq - NM_001081132
RefSeq - XM_006497486
RefSeq Peptide - NP_001074601
swissprot - F6Q3G7
swissprot - A2AT37
Ensembl - ENSMUSG00000043241
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01068469.1ENSDARG00000111388Danio rerio
 UPF2ENSGALG00000033772Gallus gallus
 UPF2ENSG00000151461Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003890  MIF4G-like, type 3
 IPR007193  Up-frameshift suppressor 2
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
 biological_processGO:0001889 liver development IMP
 biological_processGO:0006986 response to unfolded protein ISO
 biological_processGO:0031100 animal organ regeneration IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005844 polysome IBA
 cellular_componentGO:0035145 exon-exon junction complex ISO
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042162 telomeric DNA binding ISO


Pathways (from Reactome)
Pathway description
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cacnb4lh/Cacnb4lh
Genetic Background: involves: BALB/cGn

 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cacnb4lh/Cacnb4lh
Genetic Background: involves: BALB/cGn

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Cacnb4lh/Cacnb4lh
Genetic Background: involves: BALB/cGn

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Cacnb4lh/Cacnb4lh
Genetic Background: involves: BALB/cGn

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cacnb4lh/Cacnb4lh
Genetic Background: involves: BALB/cGn

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cacnb4lh/Cacnb4lh
Genetic Background: involves: BALB/cGn

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cacnb4lh/Cacnb4lh
Genetic Background: involves: BALB/cGn

 MP:0002594 low mean erythrocyte count "less than average numbers of red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cacnb4lh/Cacnb4lh
Genetic Background: involves: BALB/cGn

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cacnb4lh/Cacnb4lh
Genetic Background: involves: BALB/cGn

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cacnb4lh/Cacnb4lh
Genetic Background: involves: BALB/cGn

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cacnb4lh/Cacnb4lh
Genetic Background: involves: BALB/cGn

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cacnb4lh/Cacnb4lh
Genetic Background: involves: BALB/cGn

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cacnb4lh/Cacnb4lh
Genetic Background: involves: BALB/cGn

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cacnb4lh/Cacnb4lh
Genetic Background: involves: BALB/cGn

 MP:0008249 abnormal common lymphocyte progenitor cell morphology "any structural anomaly of a progenitor cell committed to the lymphoid lineage" [CL:0000051, PMID:10407577]
Show

Allelic Composition: Cacnb4lh/Cacnb4lh
Genetic Background: involves: BALB/cGn

 MP:0008758 abnormal T cell receptor beta chain V(D)J recombination "any anomaly in the process by which V, D, and J segments of the T cell receptor beta chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cacnb4lh/Cacnb4lh
Genetic Background: involves: BALB/cGn

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Cacnb4lh/Cacnb4lh
Genetic Background: involves: BALB/cGn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038398 Upf3a / UPF3 regulator of nonsense transcripts homolog A (yeast) / Q9H1J1* / UPF3A, regulator of nonsense mediated mRNA decay*  / complex
 ENSMUSG00000078676 Casc3 / Q8K3W3 / Protein CASC3 / O15234* / cancer susceptibility 3*  / complex
 ENSMUSG00000028609 Magoh / P61327 / Protein mago nashi homolog / P61326* / mago homolog, exon junction complex core component*  / complex
 ENSMUSG00000038374 Rbm8a / Q9CWZ3 / RNA-binding protein 8A / Q9Y5S9* / RNA binding motif protein 8A*  / complex
 ENSMUSG00000094973 Gm8994 / EIF4A3* / P38919* / eukaryotic translation initiation factor 4A3*  / complex
 ENSMUSG00000034681 Rnps1 / Q99M28 / RNA-binding protein with serine-rich domain 1 / Q15287*  / complex
 ENSMUSG00000025580 Eif4a3 / Q91VC3 / Eukaryotic initiation factor 4A-III Eukaryotic initiation factor 4A-III, N-terminally processed / P38919* / eukaryotic translation initiation factor 4A3*  / complex
 ENSMUSG00000058301 Upf1 / Q9EPU0 / UPF1 regulator of nonsense transcripts homolog (yeast) / Q92900* / UPF1, RNA helicase and ATPase*  / complex
 ENSMUSG00000036572 Upf3b / UPF3 regulator of nonsense transcripts homolog B (yeast) / Q9BZI7* / UPF3B, regulator of nonsense mediated mRNA decay*  / complex






 

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