ENSMUSG00000058301


Mus musculus

Features
Gene ID: ENSMUSG00000058301
  
Biological name :Upf1
  
Synonyms : Q9EPU0 / Upf1 / UPF1 regulator of nonsense transcripts homolog (yeast)
  
Possible biological names infered from orthology : Q92900 / UPF1, RNA helicase and ATPase
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: B3.3
Gene start: 70331525
Gene end: 70353278
  
Corresponding Affymetrix probe sets: 10579234 (MoGene1.0st)   1419685_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000075089
Ensembl peptide - ENSMUSP00000148927
NCBI entrez gene - 19704     See in Manteia.
MGI - MGI:107995
RefSeq - XM_006509605
RefSeq - NM_001122829
RefSeq - NM_030680
RefSeq - XM_006509604
RefSeq Peptide - NP_001116301
RefSeq Peptide - NP_109605
swissprot - Q9EPU0
Ensembl - ENSMUSG00000058301
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 upf1ENSDARG00000016302Danio rerio
 UPF1ENSGALG00000003220Gallus gallus
 UPF1ENSG00000005007Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Helz2 / E9QAM5 / Helicase with zinc finger domain 2 / Q9BYK8* / helicase with zinc finger 2*ENSMUSG0000002758018
Helz / Q6DFV5 / Probable helicase with zinc finger domain / P42694* / helicase with zinc finger*ENSMUSG0000002072117
Mov10 / P23249 / Putative helicase MOV-10 / Q9HCE1* / Mov10 RISC complex RNA helicase*ENSMUSG0000000222716
Mov10l1 / Mov10 RISC complex RNA helicase like 1 / Q9BXT6*ENSMUSG0000001536515


Protein motifs (from Interpro)
Interpro ID Name
 IPR006935  Helicase/UvrB, N-terminal
 IPR018999  RNA helicase UPF1, UPF2-interacting domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
 biological_processGO:0000294 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay IEA
 biological_processGO:0000956 nuclear-transcribed mRNA catabolic process IEA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006449 regulation of translational termination IEA
 biological_processGO:0009048 dosage compensation by inactivation of X chromosome IMP
 biological_processGO:0032201 telomere maintenance via semi-conservative replication IEA
 biological_processGO:0032204 regulation of telomere maintenance IEA
 biological_processGO:0044770 cell cycle phase transition IEA
 biological_processGO:0061014 positive regulation of mRNA catabolic process IEA
 biological_processGO:0061158 3"-UTR-mediated mRNA destabilization IEA
 biological_processGO:0071044 histone mRNA catabolic process IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0035145 exon-exon junction complex IEA
 cellular_componentGO:0044530 supraspliceosomal complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042162 telomeric DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Eif2ak2tm1Cwe/Eif2ak2tm1Cwe,Rnaseltm1Slvm/Rnaseltm1Slvm
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Eif2ak2tm1Cwe/Eif2ak2tm1Cwe,Rnaseltm1Slvm/Rnaseltm1Slvm
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0009687 empty decidua capsularis "the implanted embryo normally covered opposite the placenta by uterine mucosa and epithelium following implantation is missing, suggesting the embryo died early during implantation but after the decidual response and modification of uterine stromal cells" [ISBN:0198542771 "Rugh, Roberts, The Mouse: Its Reproduction and Development", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eif2ak2tm1Cwe/Eif2ak2tm1Cwe,Rnaseltm1Slvm/Rnaseltm1Slvm
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Eif2ak2tm1Cwe/Eif2ak2tm1Cwe,Rnaseltm1Slvm/Rnaseltm1Slvm
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002210 Smg9 / Q9DB90 / Protein SMG9 / Q9H0W8* / SMG9, nonsense mediated mRNA decay factor*  / complex
 ENSMUSG00000020495 Smg8 / Q8VE18 / Protein SMG8 / Q8ND04* / SMG8, nonsense mediated mRNA decay factor*  / complex
 ENSMUSG00000030655 Smg1 / Q8BKX6 / Serine/threonine-protein kinase SMG1 / Q96Q15* / SMG1, nonsense mediated mRNA decay associated PI3K related kinase*  / complex
 ENSMUSG00000043241 Upf2 / UPF2 regulator of nonsense transcripts homolog (yeast) / Q9HAU5* / UPF2, regulator of nonsense mediated mRNA decay*  / complex






 

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