ENSDARG00000016302


Danio rerio

Features
Gene ID: ENSDARG00000016302
  
Biological name :upf1
  
Synonyms : upf1 / upf1 regulator of nonsense transcripts homolog (yeast)
  
Possible biological names infered from orthology : Q92900 / Q9EPU0 / UPF1, RNA helicase and ATPase
  
Species: Danio rerio
  
Chr. number: 2
Strand: 1
Band:
Gene start: 56168619
Gene end: 56237133
  
Corresponding Affymetrix probe sets: Dr.13594.1.S1_at (Zebrafish Array)   Dr.7841.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000013006
Ensembl peptide - ENSDARP00000140654
Ensembl peptide - ENSDARP00000153550
swissprot - A0A0R4IY20
swissprot - F1RCY6
ZFIN ID - ZDB-GENE-040426-2836
Ensembl - ENSDARG00000016302
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 UPF1ENSGALG00000003220Gallus gallus
 UPF1ENSG00000005007Homo sapiens
 Upf1ENSMUSG00000058301Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
helz / helicase with zinc finger / P42694*ENSDARG0000003056017
helz2 / helicase with zinc finger 2, transcriptional coactivatorENSDARG0000001652717
mov10a / Mov10 RISC complex RNA helicase a / MOV10* / Q9HCE1* / Mov10 RISC complex RNA helicase*ENSDARG0000001582917
Q1LXK4 / mov10b.1 / Moloney leukemia virus 10b, tandem duplicate 1 / MOV10* / Q9HCE1* / P23249* / Putative helicase MOV-10 * / Mov10 RISC complex RNA helicase*ENSDARG0000006117716
Q1LXK5 / mov10b.2 / Moloney leukemia virus 10b, tandem duplicate 2 / MOV10* / Q9HCE1* / P23249* / Putative helicase MOV-10 * / Mov10 RISC complex RNA helicase*ENSDARG0000005606516
si:dkey-97a13.6ENSDARG0000001260011
AL935128.1 / HELZ2* / E9QAM5* / Q9BYK8* / helicase with zinc finger 2* / Helicase with zinc finger domain 2 *ENSDARG000000124464


Protein motifs (from Interpro)
Interpro ID Name
 IPR006935  Helicase/UvrB, N-terminal
 IPR018999  RNA helicase UPF1, UPF2-interacting domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
 biological_processGO:0000956 nuclear-transcribed mRNA catabolic process IMP
 biological_processGO:0043009 chordate embryonic development IMP
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain necrotic , abnormal
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 ZFA:0000012 central nervous system central nervous system necrotic , abnormal
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 ZFA:0000037 anatomical structure anatomical structure increased amount , abnormal
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 ZFA:0000106 extension extension disorganized , abnormal
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 ZFA:0000155 somite somite malformed , abnormal
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 ZFA:0000279 segmental plate segmental plate increased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism anterior-posterior axis decreased length , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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