ENSGALG00000003220


Gallus gallus

Features
Gene ID: ENSGALG00000003220
  
Biological name :UPF1
  
Synonyms : UPF1 / UPF1, RNA helicase and ATPase
  
Possible biological names infered from orthology : Q92900 / Q9EPU0 / UPF1 regulator of nonsense transcripts homolog (yeast)
  
Species: Gallus gallus
  
Chr. number: 28
Strand: -1
Band:
Gene start: 3764045
Gene end: 3781142
  
Corresponding Affymetrix probe sets: GgaAffx.25781.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000005090
NCBI entrez gene - 420119     See in Manteia.
RefSeq - XM_015300128
RefSeq - XM_015300129
swissprot - E1C0J4
Ensembl - ENSGALG00000003220
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 upf1ENSDARG00000016302Danio rerio
 UPF1ENSG00000005007Homo sapiens
 Upf1ENSMUSG00000058301Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HELZ / helicase with zinc finger / P42694* / Q6DFV5* / Probable helicase with zinc finger domain *ENSGALG0000002715217
MOV10 / putative helicase MOV-10 / P23249* / Q9HCE1* / Mov10 RISC complex RNA helicase*ENSGALG0000000155815
HELZ2 / helicase with zinc finger 2 / E9QAM5* / Q9BYK8* / Helicase with zinc finger domain 2 *ENSGALG000000061389
MOV10L1 / Mov10 RISC complex RNA helicase like 1 / Q9BXT6*ENSGALG000000336644


Protein motifs (from Interpro)
Interpro ID Name
 IPR006935  Helicase/UvrB, N-terminal
 IPR018999  RNA helicase UPF1, UPF2-interacting domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
 biological_processGO:0000294 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay IEA
 biological_processGO:0000956 nuclear-transcribed mRNA catabolic process IEA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006449 regulation of translational termination IEA
 biological_processGO:0009048 dosage compensation by inactivation of X chromosome IEA
 biological_processGO:0032201 telomere maintenance via semi-conservative replication IEA
 biological_processGO:0032204 regulation of telomere maintenance IEA
 biological_processGO:0044770 cell cycle phase transition IEA
 biological_processGO:0061014 positive regulation of mRNA catabolic process IEA
 biological_processGO:0061158 3"-UTR-mediated mRNA destabilization IEA
 biological_processGO:0071044 histone mRNA catabolic process IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0035145 exon-exon junction complex IEA
 cellular_componentGO:0044530 supraspliceosomal complex IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042162 telomeric DNA binding IEA


Pathways (from Reactome)
Pathway description
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000006829 SMG1 / SMG1, nonsense mediated mRNA decay associated PI3K related kinase / Q8BKX6* / Q96Q15* / Serine/threonine-protein kinase SMG1 *  / complex






 

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